Differential Expression of Candida albicans Secreted Aspartyl Proteinase and Phospholipase B Genes in Humans Correlates with Active Oral and Vaginal Infections
Naglik, Julian R., Rodgers, Catherine A., Shirlaw, Penelope J., Dobbie, Jennifer L., Fernandes‐Naglik, Lynette L., Greenspan, Deborah, Agabian, Nina, Challacombe, Stephen J.·2003·The Journal of Infectious Diseases
DOI 10.1086/376536
Cited by (196)
Items 101–196 of 196
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- <i>Candida auris</i>
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- Standardisation of high throughput microdilution antifungal susceptibility testing for Candida albicans and Cryptococcus neoformansHolly E. E. Floyd, Angela M. Kavanagh, Gabrielle J. Lowe, Maite Amado, James A. Fraser, Mark A. T. Blaskovich, Alysha G. Elliott, Johannes Zuegg · 2024 · Scientific Reports
- Upregulation of secreted aspartyl proteinase genes of fluconazole-sensitive Candida albicans isolatesCarolina Do Rosário Esteves Guimarães, H. F. de Freitas, T. Barros · 2019 · Molecular Biology Reports
- Infection Transmission by Saliva and the Paradoxical Protective Role of SalivaJacobo Limeres Posse, Pedro Diz Dios, C. Scully · 2017 · Saliva Protection and Transmissible Diseases
- Phospholipase Activity of Candida Species Isolated from Diabetic PatientsN. Amini, R. Mohammadi · 2023 · Advanced Biomedical Research
- Gene expression of Candida albicans strains isolates from patients with denture stomatitis submitted to treatments with photodynamic therapy and nystatin.G. Alonso, C. Jordão, M. Klein, J. C. Carmello, A. C. Pavarina · 2021 · Photodiagnosis and Photodynamic Therapy
- Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitroB. Falkensammer, L. Pleyer, S. Ressler, A. Berg, Margarethe Borg-von Zepelin, M. Nagl, C. Lass-Flörl, C. Speth, M. P. Dierich, R. Würzner · 2008 · Mycoses (Berlin)
- Impact of high SAP2 expression on the invasion and adhesion abilities of Candida albicans in vaginal epithelial cells.Lan Xue, Lu Yang, Xi-Ze Fu, Wen-Li Feng, Jing Yang, Yan Ma, Zhiqin Xi · 2025 · Biochemical and Biophysical Research Communications - BBRC
- Candida albicans: Clinical Relevance, Pathogenesis, and Host ImmunityAlexandra Correia, Paula Sampaio, Manuel Vilanova, Célia Pais · 2015 · Wiley eBooks
- Fungal Aspartic Proteases as Possible Therapeutic TargetsM. Monod, P. Staib, U. Reichard, O. Jousson · 2011 · Methods and principles in medicinal chemistry
- Fungal pathogens and symbionts: Living off the fat of the landNev, Olga A., David-Palma, Márcia, Heitman, Joseph, Brown, Alistair J. P., Coelho, Marco A. · 2024 · PLOS Pathogens
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- Determination the Gene Expression Levels of adhesins and Extracellular Enzymes Genes in Candida albicans biofilm producer by Quantitative Real Time PCR Technique (qRT-PCR)Najwan Abbas Mohammed, H. A. Ajah, N. J. Abdulbaqi · 2021 · Indian Journal of Forensic Medicine & Toxicology
- Roles of Candida albicans aspartic proteases in host-pathogen interactionsM. Gogól, O. Bocheńska, Marcin Zawrotniak, J. Karkowska-Kuleta, D. Zając, M. Rapała-Kozik · 2017 · Springer eBooks
- Humoral Factors in the Protection of the Oral Cavity against CandidiasisS. Challacombe, D. Rahman, Mukesh Mistry, J. Naglik · 2005 · Springer eBooks
- Characterization and virulence of yeasts associated with neonatal thrushEman G. A. El-Dawy, Abeer Baddar, Y. Gherbawy, A. Yassein · 2025 · BMC Microbiology
- Oral candidiasis in HIV-uninfected pediatric population in areas with limited fungal diagnosis: A case study from a tertiary hospital, TanzaniaMartha F. Mushi, N. Loi, S. Mshana · 2021 · Therapeutic Advances in Infectious Disease
- Secreted Candida Proteins: Pathogenicity and Host ImmunityJ. Naglik, B. Hube · 2010 · Springer eBooks
- Fluconazole tolerance and virulence adaptations of Candida albicans isolated from head and neck cancer patientsPhimchat Suwannaphong, P. Thammasit, Artid Amsri, Waranyu Ueangphairot, Pooriwat Muangwong, Kittikun Kittidachanan, I. Chitapanarux, Jiraporn Kantapan, Nathupakorn Dechsupa, S. Youngchim · 2025 · Journal of Oral Microbiology
- VAGINAL CANDIDIASIS - GYNECOLOGICAL ASPECT OF THE PROBLEMR. Živadinović, A. Petrič, D. Krtinić · 2014
- Detection of Phospholipase and Asparty1 Protaines gens in Candida Species Isolated From Mammary Candidiasis in Lactating WomenAbrar Mohammed Qneed Al-Dafay, Khairi Jameel AL-Ruaby, Alwan Abed Hamadi AlQushawi · 2021 · Indian Journal of Forensic Medicine & Toxicology
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- Vulvovaginal CandidosisA. H. Bhesania, A. Narayankhedkar · 2017 · International Journal of Current Microbiology and Applied Sciences
- Postgenomic Approaches to Analyse Candida albicans PathogenicityC. Munro, C. Fradin, O. Bader, B. Hube · 2006 · Springer eBooks
- Molecular Pathogenesis of Fungal InfectionsB. Segal · 2006 · Humana Press eBooks
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- Genotypic Patterns of Secreted Aspartyl Proteinase Gene in Various Candida Species Isolated from Antenatal Women with Vulvovaginal CandidiasisK. Das, V. Mangayarkarasi, Maitraye Sen · 2019 · Journal of Pure and Applied Microbiology
- Molecular analysis of candida albicans Secreted Aspartyl Proteinase 3 (SAP3) Indonesian isolateA. T. Permata, A. A. Prasetyo, S. Haryati · 2018 · IOP Conference Series: Materials Science and Engineering
- In-vitro Evaluation of Antifungal Activity of Ganoderma lucidum Against the Biofilm Producing Candida speciesC. Naveenkumar, G. Jayalakshmi, R. Chidambaram, R. Srikumar · 2017
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- Candida Pathogenicity and Alternative Therapeutic StrategiesN. Manzoor · 2019 · Pathogenicity and Drug Resistance of Human Pathogens
- CHAPTER 26 – Fungal infections of the genitourinary tractJ. Sobel · 2009 · Elsevier eBooks
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