Fungal pathogens and symbionts: Living off the fat of the land
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In nutrient-poor environments without glucose, C. albicans uses alternative carbon metabolism.
“However, in nutrient-poor environments without glucose, C. albicans must scavenge and use alternative carbon metabolism (30).”
From <i>Candida auris</i> metabolism and growth preferences in physiologically relevant skin-like conditions (2026) · cites this paper as [30]
The Introduction (page not provided) says that C. albicans has nutrient-acquisition and uptake machinery that facilitates scavenging in host niches, and describes environmentally contingent metabolic flexibility. It does not specify nutrient-poor, glucose-free conditions or say that C. albicans must use alternative carbon metabolism under those conditions. (LLM, conf=0.86)
Experimental — accuracy not yet measuredBoth conventional and alternative carbon metabolism allow C. albicans to grow in various nutrient sources.
“Taken together, both conventional and alternative carbon metabolism allow C. albicans to grow in various nutrient sources.”
From <i>Candida auris</i> metabolism and growth preferences in physiologically relevant skin-like conditions (2026) · cites this paper as [30]
The Introduction (page not available) says C. albicans has expanded nutrient-acquisition and uptake machinery that supports nutrient scavenging and metabolic flexibility across host niches. It does not specifically say that both conventional and alternative carbon metabolism enable growth on various nutrient sources. (LLM, conf=0.84)
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Cites
Topographic diversity of fungal and bacterial communities in human skin
NIH Intramural Sequencing Center Comparative Sequencing Program, Findley, K., Oh, J., Yang, J., Conlan, S., Deming, C., Meyer, J. A., Schoenfeld, D., Nomicos, E., Park, M., et al. (2013) · Nature · doi:10.1038/nature12171 · Cited by 1,206 · see citing works
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Proctor, D. M., Dangana, T., Sexton, D. J., Fukuda, C., Yelin, R. D., Stanley, M., Bell, P. B., Baskaran, S., Deming, C., Chen, Q., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01383-w · Cited by 198 · see citing works
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Cited by
Sorted by citations
Nicklas, J. P., Deming, C., Lee-Lin, S., Conlan, S., Shen, Z., Blaustein, R. A., & Segre, J. A. (2026) · mBio · doi:10.1128/mbio.03117-25 · Cited by 8 · see citing works
- Authors
- Nev, O. A., David-Palma, M., Heitman, J., Brown, A. J. P., & Coelho, M. A.
- Affiliations
- University of Exeter (GB)
- Duke Medical Center (US)
- Corresponding author
- Nev, Olga A.
- Venue
- PLOS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2024-09-26
- Volume
- 20
- Issue
- 9
- Pages
- e1012551
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC11426481
- OpenAlex
- W4402897043
- Cited by
- 5
- References
- 3
- Citations by year
- 2026: 4 · 2025: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Medical Research Council (MR/V006169/1, MR/N006364/2, MR/V033417/1)
- NIHR Exeter Biomedical Research Centre (NIHR203320)
- Wellcome Trust (224323/Z/21/Z)
- NIH/NIAID R01 (AI39115-27, AI050113-20, AI170543-02, AI172451-02, AI133654-07)
- NIH/NIAID R21 (AI168672-02)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Plant Pathogens and Fungal Diseases
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Entomopathogenic Microorganisms in Pest Control
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycorrhizal Fungi and Plant Interactions
- Keywords
- fungal pathogens, fungal symbionts, host-pathogen interaction, host exploitation
- MeSH terms
- Animals, Fungi, Humans, Symbiosis
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