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Cited by 280Parasitic infections in humans and animalsParasitic Infections and DiagnosticsParasites and Host Interactions

The DOI matches its Crossref record.

Percutaneous Aspiration-Injection-Reaspiration Drainage Plus Albendazole or Mebendazole for Hepatic Cystic Echinococcosis: A Meta-analysis

Smego, R. A., Bhatti, S., Khaliq, A. A., Beg, M. A.·2003·Clinical Infectious Diseases
DOI 10.1086/378275
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Abstract

Using meta-analysis methodology, we compared the clinical outcomes for 769 patients with hepatic cystic echinococcosis treated with percutaneous aspiration-injection-reaspiration (PAIR) plus albendazole or mebendazole (group 1) with 952 era-matched historical control subjects undergoing surgical intervention (group 2). The rate of clinical and parasitologic cure (P<.0001) was greater in patients receiving PAIR plus chemotherapy. Disease recurrence (P<.0001), major complications (anaphylaxis, biliary fistula, cyst infection, liver/intra-abdominal abscess, and sepsis; P<.0001), minor complications (P<.0001), and death (P<.0824) occurred more frequently among surgical control subjects. Fever (P<.002) and minor allergic reactions subjects (P<.0001) were more common among PAIR-treated subjects. The mean durations of hospital stay were 2.4 days for group 1 and 15.0 days for group 2 (P<.001). Compared with surgery, PAIR plus chemotherapy is associated with greater clinical and parasitologic efficacy; lower rates of morbidity, mortality, and disease recurrence; and shorter hospital stays.

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  • PAIR in combination with albendazole or mebendazole has been evaluated as a highly useful strategy for managing cystic hydatidosis.

    “this method (PAIR) in combination with albendazole or mebendazole has been evaluated as a highly useful strategy for managing cystic hydatidosis [174,175,181,182]”

    From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [181]

  • PAIR plus pre- or post-operative mebendazole therapy brought about greater clinical and parasitological efficacy compared with surgery alone.

    “PAIR plus pre- or post-operative mebendazole therapy brought about greater clinical and parasitological efficacy compared with surgery alone [168,181,182]”

    From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [181]

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Metadata

Authors
Smego, R. A., Bhatti, S., Khaliq, A. A., & Beg, M. A.
Affiliations
  • Aga Khan University (PK)
  • University of Oklahoma Health Sciences Center (US)
Corresponding author
Smego, R. A.
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2003-10-15
Volume
37
Issue
8
Pages
1073-1083
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/378275
OpenAlex
W2153246863
Cited by
280
References
0
Citations by year
2026: 5 · 2025: 14 · 2024: 7 · 2023: 16 · 2022: 7 · 2021: 24 · 2020: 12 · 2019: 10 · 2018: 9 · 2017: 16 · 2016: 14 · 2015: 17 · 2014: 16 · 2013: 9 · 2012: 17
FWCI
1.16
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • eCommons - AKU (Aga Khan University) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords
hepatic hydatid cyst, pairs, albendazole, mebendazole, antiparasitic chemotherapy, surgical treatment, recurrence, post-procedural complications, length of hospital stay, echinococcosis
MeSH terms
Animals, Anthelmintics, Drainage, Echinococcosis, Hepatic, Echinococcus, Humans, Injections, Length of Stay, Mebendazole, Recurrence, Albendazole, Treatment Outcome

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