The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Impact of Mannose-Binding Lectin on Susceptibility to Infectious Diseases
Open accessAbstract
When the adaptive immune response is either immature or compromised, the innate immune system constitutes the principle defense against infection. Mannose-binding lectin (MBL) is a C-type serum lectin that plays a central role in the innate immune response. MBL binds microbial surface carbohydrates and mediates opsonophagocytosis directly and by activation of the lectin complement pathway. A wide variety of clinical isolates of bacteria, fungi, viruses, and parasites are bound by MBL. Three polymorphisms in the structural gene MBL2) and 2 promoter gene polymorphisms are commonly found that result in production of low serum levels of MBL. Clinical studies have shown that MBL insufficiency is associated with bacterial infection in patients with neutropenia and meningococcal sepsis. Low MBL levels appear to predispose persons to HIV infection. Numerous other potential infectious disease associations have been described. Therapy to supplement low MBL levels is being explored using either plasma-derived or recombinant material.
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Cites
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ASSOCIATION OF LOW LEVELS OF MANNAN-BINDING PROTEIN WITH A COMMON DEFECT OF OPSONISATION
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Recurrent Vulvovaginal Candidiasis: An Immunological Perspective
Rosati, D., Bruno, M., Jaeger, M., ten Oever, J., & Netea, M. G. (2020) · Microorganisms · doi:10.3390/microorganisms8020144 · Cited by 206
Bitter-sweet symphony: glycan–lectin interactions in virus biology
Van Breedam, W., Pöhlmann, S., Favoreel, H. W., de Groot, R. J., & Nauwynck, H. J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12052 · Cited by 141
He, T., Zhou, B., Sun, G., Yan, Q., Lin, S., Ma, G., Yao, Q., Wu, X., Zhong, Y., Gan, D., et al. (2024) · Cell Death & Differentiation · doi:10.1038/s41418-023-01243-9 · Cited by 19
Metadata
- Authors
- Eisen, D. P., & Minchinton, R. M.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-01
- Volume
- 37
- Issue
- 11
- Pages
- 1496-1505
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2100967062
- Cited by
- 435
- References
- 51
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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