The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Frequent Detection of Human Coronaviruses in Clinical Specimens from Patients with Respiratory Tract Infection by Use of a Novel Real‐Time Reverse‐Transcriptase Polymerase Chain Reaction
Open accessAbstract
During the past years, human coronaviruses (HCoVs) have been increasingly identified as pathogens associated with more-severe respiratory tract infection (RTI). Diagnostic tests for HCoVs are not frequently used in the routine setting. It is likely that, as a result, the precise role that HCoVs play in RTIs is greatly underestimated. We describe a rapid, sensitive, and highly specific quantitative real-time reverse-transcriptase polymerase chain reaction (RT-PCR) for the detection of HCoV that can easily be implemented in the routine diagnostic setting. HCoV was detected in 28 (11%) of the 261 clinical specimens obtained from patients presenting with symptoms of RTI ranging from common cold to severe pneumonia. Only 1 (0.4%) of the 243 control specimens obtained from patients without symptoms of RTI showed the presence of HCoV. We conclude that HCoVs can be frequently detected in patients presenting with RTI. Real-time RT-PCR provides a tool for large-scale epidemiological studies to further clarify the role that coronavirus infection plays in RTI in humans.
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Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574
Viruses and bacteria in the etiology of the common cold
Mäkelä, M. J., Puhakka, T., Ruuskanen, O., Leinonen, M., Saikku, P., Kimpimäki, M., Blomqvist, S., Hyypiä, T., & Arstila, P. (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.2.539-542.1998 · Cited by 768
Cited by
Lamson, D., Renwick, N., Kapoor, V., Liu, Z., Palacios, G., Ju, J., Dean, A., St. George, K., Briese, T., & Ian Lipkin, W. (2006) · The Journal of Infectious Diseases · doi:10.1086/508551 · Cited by 339
Emerging respiratory agents: New viruses for old diseases?
Sloots, T. P., Whiley, D. M., Lambert, S. B., & Nissen, M. D. (2008) · Journal of Clinical Virology · doi:10.1016/j.jcv.2008.03.002 · Cited by 124
Metadata
- Authors
- van Elden, L. J. R., van Loon, A. M., van Alphen, F., Hendriksen, K. A. W., Hoepelman, A. I. M., van Kraaij, M. G. J., Oosterheert, J., Schipper, P., Schuurman, R., & Nijhuis, M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-02-15
- Volume
- 189
- Issue
- 4
- Pages
- 652-657
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2155523942
- Cited by
- 225
- References
- 2
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van Elden, L. J. R., van Loon, A. M., van Alphen, F., Hendriksen, K. A. W., Hoepelman, A. I. M., van Kraaij, M. G. J., Oosterheert, J., Schipper, P., Schuurman, R., & Nijhuis, M. (2004). Frequent Detection of Human Coronaviruses in Clinical Specimens from Patients with Respiratory Tract Infection by Use of a Novel Real‐Time Reverse‐Transcriptase Polymerase Chain Reaction. The Journal of Infectious Diseases. https://doi.org/10.1086/381207
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