The DOI matches its Crossref record.
Superiority of Reverse‐Transcription Polymerase Chain Reaction to Conventional Viral Culture in the Diagnosis of Acute Respiratory Tract Infections in Children
Open accessAbstract
We compared the rates of detection of respiratory viruses by reverse-transcription polymerase chain reaction (RT-PCR) and by conventional viral culture in 668 combined nasal and throat samples from a prospective, multicenter, population-based study of acute respiratory tract infections among hospitalized children aged <5 years. RT-PCR increased the yield of viral identification by 2-fold, compared with that of culture alone. The increased sensitivity of viral detection by RT-PCR will yield better estimates of the population burden of viral respiratory infections.
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Citations
Cited by
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Self-citationEfficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis
Osterholm, M. T., Kelley, N. S., Sommer, A., & Belongia, E. A. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70295-x · Cited by 1,789
Cellular immune correlates of protection against symptomatic pandemic influenza
Sridhar, S., Begom, S., Bermingham, A., Hoschler, K., Adamson, W., Carman, W., Bean, T., Barclay, W., Deeks, J. J., & Lalvani, A. (2013) · Nature Medicine · doi:10.1038/nm.3350 · Cited by 862
The Underrecognized Burden of Influenza in Young Children
Poehling, K. A., Edwards, K. M., Weinberg, G. A., Szilagyi, P., Staat, M. A., Iwane, M. K., Bridges, C. B., Grijalva, C. G., Zhu, Y., Bernstein, D. I., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054869 · Cited by 872
Self-citationIwane, M. K., Edwards, K. M., Szilagyi, P. G., Walker, F. J., Griffin, M. R., Weinberg, G. A., Coulen, C., Poehling, K. A., Shone, L. P., Balter, S., et al. (2004) · Pediatrics · doi:10.1542/peds.113.6.1758 · Cited by 542
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Metadata
- Authors
- Weinberg, G. A., Erdman, D. D., Edwards, K. M., Hall, C. B., Walker, F. J., Griffin, M. R., Schwartz, B., & the New Vaccine Surveillance Network Study Group
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-02-15
- Volume
- 189
- Issue
- 4
- Pages
- 706-710
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2027478882
- Cited by
- 230
- References
- 0
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Superiority of Reverse‐Transcription Polymerase Chain Reaction to Conventional Viral Culture in the Diagnosis of Acute Respiratory Tract Infections in Children. https://app.cochat.ai/papers/10.1086/381456
- The paper
- Weinberg, G. A., Erdman, D. D., Edwards, K. M., Hall, C. B., Walker, F. J., Griffin, M. R., Schwartz, B., & the New Vaccine Surveillance Network Study Group. (2004). Superiority of Reverse‐Transcription Polymerase Chain Reaction to Conventional Viral Culture in the Diagnosis of Acute Respiratory Tract Infections in Children. The Journal of Infectious Diseases. https://doi.org/10.1086/381456
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
