The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Prevalence of Pertussis Antibodies in Maternal Delivery, Cord, and Infant Serum
Abstract
BACKGROUND: Passively acquired maternal antibodies protect infants from many pathogens. With increasing reports of infant pertussis, we evaluated pertussis antibodies in maternal-infant paired sera from 1999-2000. METHODS: Antibodies to pertussis toxin (PT), filamentous hemagglutinin (FHA), and fimbrial proteins (FIM) were measured by validated IgG-specific enzyme-linked immunosorbant assay (ELISA) in 64 maternal-umbilical cord serum pairs and in 61 of 64 infant sera. Geometric mean concentrations (GMCs) of pertussis antibodies and cord : maternal GMC ratios were calculated. RESULTS: Mean maternal age and gestation were 29.7 years (range, 19-42) and 39.3 weeks (range, 35.6-40.9), and 81% of mothers were white. GMCs of maternal antibodies at delivery (ELISA units/mL) were 2.4 for PT, 6.9 for FHA, and 13 for FIM. Cord GMCs were 169%, 178%, and 157% of maternal delivery values for PT, FHA, and FIM, respectively, demonstrating active placental transfer (P<.001). Pertussis-specific IgG values for each antigen decayed to below the threshold of detection by age 2 months. CONCLUSIONS: Despite efficient placental transfer, low maternal pertussis antibody levels and their rapid decay in infant sera leave infants with little humoral protection against pertussis. These data support the rationale for maternal or neonatal immunization, with acellular pertussis vaccines, to prevent life-threatening pertussis in early infancy.
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Citations
Cites
Deaths from pertussis are underestimated in England
Crowcroft, N. S. (2002) · Archives of Disease in Childhood · doi:10.1136/adc.86.5.336 · Cited by 113
Cited by
Effectiveness of maternal pertussis vaccination in England: an observational study
Amirthalingam, G., Andrews, N., Campbell, H., Ribeiro, S., Kara, E., Donegan, K., Fry, N. K., Miller, E., & Ramsay, M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60686-3 · Cited by 739
Munoz, F. M., Bond, N. H., Maccato, M., Pinell, P., Hammill, H. A., Swamy, G. K., Walter, E. B., Jackson, L. A., Englund, J. A., Edwards, M. S., et al. (2014) · JAMA · doi:10.1001/jama.2014.3633 · Cited by 489
Self-citationJones, C. E. (2011) · JAMA · doi:10.1001/jama.2011.100 · Cited by 236
Gall, S. A., Myers, J., & Pichichero, M. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.11.024 · Cited by 226
van den Berg, J. P., Westerbeek, E. A. M., Berbers, G. A. M., van Gageldonk, P. G. M., van der Klis, F. R. M., & van Elburg, R. M. (2010) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181dc4f77 · Cited by 112
Metadata
- Authors
- Healy, C. M., Munoz, F. M., Rench, M. A., Halasa, N. B., Edwards, K. M., & Baker, C. J.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-15
- Volume
- 190
- Issue
- 2
- Pages
- 335-340
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2146261518
- Cited by
- 229
- References
- 1
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Healy, C. M., Munoz, F. M., Rench, M. A., Halasa, N. B., Edwards, K. M., & Baker, C. J. (2004). Prevalence of Pertussis Antibodies in Maternal Delivery, Cord, and Infant Serum. The Journal of Infectious Diseases. https://doi.org/10.1086/421033
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