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First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei
Abstract
Ivermectin is increasingly being used to treat scabies, especially crusted (Norwegian) scabies. However, treatment failures, recrudescence, and reinfection can occur, even after multiple doses. Ivermectin resistance has been documented for some intestinal helminths in animals with intensive ivermectin exposure. Ivermectin resistance has also been induced in arthropods in laboratory experiments but, to date, has not been documented among arthropods in nature. We report clinical and in vitro evidence of ivermectin resistance in 2 patients with multiple recurrences of crusted scabies who had previously received 30 and 58 doses of ivermectin over 4 and 4.5 years, respectively. As predicted, ivermectin resistance in scabies mites can develop after intensive ivermectin use.
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Citations
Cited by
Moxidectin and the avermectins: Consanguinity but not identity
Prichard, R., Ménez, C., & Lespine, A. (2012) · International Journal for Parasitology: Drugs and Drug Resistance · doi:10.1016/j.ijpddr.2012.04.001 · Cited by 439
Prevalence of scabies and impetigo worldwide: a systematic review
Romani, L., Steer, A. C., Whitfeld, M. J., & Kaldor, J. M. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00132-2 · Cited by 435
Problems in Diagnosing Scabies, a Global Disease in Human and Animal Populations
Walton, S. F., & Currie, B. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-06 · Cited by 423
Self-citationPermethrin and ivermectin for scabies.
Currie, B. J., & McCarthy, J. S. (2010) · New England Journal of Medicine · doi:10.1056/nejmct0910329 · Cited by 319
Self-citationMass drug administration for scabies control in a population with endemic disease.
Romani, L., Whitfeld, M. J., Koroivueta, J., Kama, M., Wand, H., Tikoduadua, L., Tuicakau, M., Koroi, A., Andrews, R., Kaldor, J. M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500987 · Cited by 268
Metadata
- Authors
- Currie, B. J., Harumal, P., McKinnon, M., & Walton, S. F.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-01
- Volume
- 39
- Issue
- 1
- Pages
- e8-e12
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2109097527
- Cited by
- 317
- References
- 0
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Currie, B. J., Harumal, P., McKinnon, M., & Walton, S. F. (2004). First Documentation of In Vivo and In Vitro Ivermectin Resistance in Sarcoptes scabiei. Clinical Infectious Diseases. https://doi.org/10.1086/421776
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