Permethrin and ivermectin for scabies.
Abstract
A 4-year-old boy is brought to a health center with sores on his arms and legs. He and several siblings receive a diagnosis of scabies. Crusted scabies is diagnosed in an elderly aunt in the same household. The family members are treated with topical permethrin, which disrupts the function of voltage-gated sodium channels in arthropods. The aunt is treated with oral ivermectin, which disrupts the function of chloride ion channels.
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Permethrin is safe and effective with a single application.
“Permethrin is safe and effective with a single application (1411).”
From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [1411]
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Sexually Transmitted Infections Treatment Guidelines, 2021
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A Review of Scabies: An Infestation More than Skin Deep
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- Authors
- Currie, B. J., & McCarthy, J. S.
- Affiliations
- Menzies School of Health Research (AU)
- The University of Queensland (AU)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-02-25
- Volume
- 362
- Issue
- 8
- Pages
- 717-725
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2089953642
- Cited by
- 319
- References
- 51
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 15 · 2023: 19 · 2022: 14 · 2021: 14 · 2020: 22 · 2019: 19 · 2018: 33 · 2017: 18 · 2016: 28 · 2015: 20 · 2014: 22 · 2013: 23 · 2012: 21
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Dermatological diseases and infestations
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- scabies, permethrin, ivermectin, crusted scabies, oral ivermectin, voltage-gated sodium channels, chloride channels, pediatric dermatology
- MeSH terms
- Administration, Cutaneous, Administration, Oral, Aged, Animals, Child, Preschool, Female, Humans, Insecticides, Ivermectin, Life Cycle Stages, Male, Ointments, Pruritus, Sarcoptes scabiei, Scabies, Practice Guidelines as Topic, Permethrin
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