The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Evolutionary Origin and Emergence of a Highly Successful Clone of Serotype M1 Group A Streptococcus Involved Multiple Horizontal Gene Transfer Events
Open accessAbstract
To better understand the molecular events involved in the origin of new pathogenic bacteria, we studied the evolution of a highly virulent clone of serotype M1 group A Streptococcus (GAS). Genomic, DNA-DNA microarray, and single-nucleotide polymorphism analyses indicated that this clone evolved through a series of horizontal gene transfer events that involved (1) the acquisition of prophages encoding streptococcal pyrogenic exotoxin A and extracellular DNases and (2) the reciprocal recombination of a 36-kb chromosomal region encoding the extracellular toxins NAD+-glycohydrolase (NADase) and streptolysin O (SLO). These gene transfer events were associated with significantly increased production of SLO and NADase. Virtual identity in the 36-kb region present in contemporary serotype M1 and M12 isolates suggests that a serotype M12 strain served as the donor of this region. Multiple horizontal gene transfer events were a crucial factor in the evolutionary origin and emergence of a very abundant contemporary clone of serotype M1 GAS.
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Cites
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Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive Bacteria
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Metadata
- Authors
- Sumby, P., Porcella, S. F., Madrigal, A. G., Barbian, K. D., Virtaneva, K., Ricklefs, S. M., Sturdevant, D. E., Graham, M. R., Vuopio‐Varkila, J., Hoe, N. P., & Musser, J. M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09
- Volume
- 192
- Issue
- 5
- Pages
- 771-782
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2001129735
- Cited by
- 360
- References
- 41
- FWCI
- 23.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sumby, P., Porcella, S. F., Madrigal, A. G., Barbian, K. D., Virtaneva, K., Ricklefs, S. M., Sturdevant, D. E., Graham, M. R., Vuopio‐Varkila, J., Hoe, N. P., & Musser, J. M. (2005). Evolutionary Origin and Emergence of a Highly Successful Clone of Serotype M1 Group A Streptococcus Involved Multiple Horizontal Gene Transfer Events. The Journal of Infectious Diseases. https://doi.org/10.1086/432514
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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