The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae
Open accessAbstract
Significance: Carbapenem-resistant Klebsiella pneumoniae has emerged globally as a multidrug-resistant hospital pathogen for which there are few treatment options. Clinical isolates classified by multilocus sequence typing (ST) as ST258 are the most widespread. The basis for the success of ST258 organisms above and beyond antibiotic resistance is not known, nor is it clear whether infections are caused by a single clone. We used genome sequencing to reveal unexpected genetic diversity among ST258 organisms (thus disproving the single-clone hypothesis) and identified a recombination hotspot that accounts for the majority of divergence—and presumably for serologic variation—among ST258 clinical isolates. Our findings will facilitate the development of new clinical strategies designed to prevent or treat infections caused by multidrug-resistant K. pneumoniae .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
(1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,715
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data
McKenna, A., Hanna, M., Banks, E., Sivachenko, A., Cibulskis, K., Kernytsky, A., Garimella, K., Altshuler, D., Gabriel, S., Daly, M., et al. (2010) · Genome Research · doi:10.1101/gr.107524.110 · Cited by 27,895
MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform
Katoh, K. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf436 · Cited by 17,027
Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically
Ferraro, M. J. (2000) · Cited by 16,875
Velvet: Algorithms for de novo short read assembly using de Bruijn graphs
Zerbino, D. R., & Birney, E. (2008) · Genome Research · doi:10.1101/gr.074492.107 · Cited by 9,491
Clinical and Laboratory Standards Institute
(2019) · Springer Reference Medizin · doi:10.1007/978-3-662-48986-4_300416 · Cited by 5,091
BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons
Alikhan, N.-F., Petty, N. K., Ben Zakour, N. L., & Beatson, S. A. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-402 · Cited by 3,303
Wikler, M. A., & Clinical (2006) · Clinical and Laboratory Standards Institute eBooks · Cited by 2,843
Identification of plasmids by PCR-based replicon typing
Carattoli, A., Bertini, A., Villa, L., Falbo, V., Hopkins, K. L., & Threlfall, E. J. (2005) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2005.03.018 · Cited by 2,319
Cited by
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread
David, S., Reuter, S., Harris, S. R., Glasner, C., Feltwell, T., Argimon, S., Abudahab, K., Goater, R., Giani, T., Errico, G., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0492-8 · Cited by 773
Holden, V. I., Wright, M. S., Houle, S., Collingwood, A., Dozois, C. M., Adams, M. D., & Bachman, M. A. (2018) · mSphere · doi:10.1128/msphere.00125-18 · Cited by 42
Metadata
- Authors
- DeLeo, F. R., Chen, L., Porcella, S. F., Martens, C. A., Kobayashi, S. D., Porter, A. R., Chavda, K. D., Jacobs, M. R., Mathema, B., Olsen, R. J., Bonomo, R. A., Musser, J. M., & Kreiswirth, B. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-03-17
- Volume
- 111
- Issue
- 13
- Pages
- 4988-4993
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2003265935
- Cited by
- 329
- References
- 36
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. https://app.cochat.ai/papers/10.1073/pnas.1321364111
- The paper
- DeLeo, F. R., Chen, L., Porcella, S. F., Martens, C. A., Kobayashi, S. D., Porter, A. R., Chavda, K. D., Jacobs, M. R., Mathema, B., Olsen, R. J., Bonomo, R. A., Musser, J. M., & Kreiswirth, B. N. (2014). Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1321364111
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
