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Cited by 201Antifungal resistance and susceptibilityFungal Plant Pathogen ControlYeasts and Rust Fungi Studies

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Amphotericin B and Caspofungin Resistance in Candida glabrata Isolates Recovered from a Critically Ill Patient

Krogh-Madsen, M., Arendrup, M. C., Heslet, L., Knudsen, J. D.·2006·Clinical Infectious Diseases
DOI 10.1086/500939
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Abstract

BACKGROUND: Consecutive Candida glabrata isolates recovered from a patient in an intensive care unit were resistant to amphotericin B (minimum inhibitory concentration, up to 32 mu g/mL; determined by Etest [AB Biodisk]). Analyses at the national reference laboratory showed that some isolates were also resistant to azoles and caspofungin. In this study, 4 isolates were studied thoroughly using susceptibility assays and a mouse model and to determine clonality. METHODS: Different broth microdilution tests, Etests, and time-kill studies for antifungals were performed in different media. Three of the 4 isolates were examined in an in vivo experiment, in which mice were challenged intravenously with 1 of 3 isolates and treated daily with amphotericin B, caspofungin, or saline. For the clonality studies, arbitrarily primed polymerase chain reaction (PCR) was performed with the 4 isolates, 8 isolates obtained from nonrelated patients, and a reference strain. RESULTS: The murine model indicated that 1 isolate was resistant to amphotericin B, 1 had intermediate susceptibility, and 1 was fully susceptible. Two of the 3 isolates were resistant to caspofungin. Microdilution methods did not reliably differentiate between amphotericin B-susceptible and -resistant isolates. All assays identified caspofungin-susceptible and -resistant isolates. Arbitrarily primed PCR showed that the 4 isolates probably were of clonal origin. CONCLUSIONS: We have documented the emergence of amphotericin B-resistant and caspofungin-resistant C. glabrata isolates during treatment of a critically ill liver transplant recipient. Only the Etest predicted amphotericin B resistance in the isolates. We recommend that important fungal strains recovered from patients who are receiving antifungal therapy should be tested for susceptibility to the antifungal drug used, because resistance can be present initially or may occur during treatment.

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Crossref · 10.1086/500939

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Metadata

Authors
Krogh-Madsen, M., Arendrup, M. C., Heslet, L., & Knudsen, J. D.
Affiliations
  • Hvidovre Hospital (DK)
  • Statens Serum Institut (DK)
Corresponding author
Knudsen, J. D.
ORCID
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2006-04-01
Volume
42
Issue
7
Pages
938-944
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/500939
OpenAlex
W2106522725
Cited by
201
References
21
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 11 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 14 · 2015: 9 · 2014: 15 · 2013: 6 · 2012: 20
FWCI
13.56
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
  • Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
Keywords
Candida glabrata, amphotericin B resistance, caspofungin resistance, antifungal resistance, critically ill patients, liver transplant recipients, clonality, E-test, antifungal susceptibility testing, time-kill assay, mouse model, azole resistance
MeSH terms
Caspofungin, Aged, Amphotericin B, Animals, Antifungal Agents, Candidiasis, Female, Humans, Microbial Sensitivity Tests, Peptides, Cyclic, Polymerase Chain Reaction, Critical Illness, Candida glabrata, Mice, Echinocandins, Lipopeptides

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