Cited by 869Herpesvirus Infections and TreatmentsCytomegalovirus and herpesvirus researchViral Infections and Immunology Research

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Recommendations for the Management of Herpes Zoster

Dworkin, Robert H., Johnson, Robert W., Breuer, Judith, Gnann, John W., Levin, Myron J., Backonja, Miroslav, Betts, Robert F., Gershon, Anne A., Haanpää, Maija L., McKendrick, Michael W., Nurmikko, Turo J., Oaklander, Anne Louise, Oxman, Michael N., Langston, Deborah Pavan, Petersen, Karin L., Rowbotham, Michael C., Schmader, Kenneth E., Stacey, Brett R., Tyring, Stephen K., Wijck, Albert J. M. van, Wallace, Mark S., Wassilew, Sawko W., Whitley, Richard J.·2007·Clinical Infectious Diseases

DOI 10.1086/510206

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Abstract

The objective of this article is to provide evidence-based recommendations for the management of patients with herpes zoster (HZ) that take into account clinical efficacy, adverse effects, impact on quality of life, and costs of treatment. Systematic literature reviews, published randomized clinical trials, existing guidelines, and the authors' clinical and research experience relevant to the management of patients with HZ were reviewed at a consensus meeting. The results of controlled trials and the clinical experience of the authors support the use of acyclovir, brivudin (where available), famciclovir, and valacyclovir as first-line antiviral therapy for the treatment of patients with HZ. Specific recommendations for the use of these medications are provided. In addition, suggestions are made for treatments that, when used in combination with antiviral therapy, may further reduce pain and other complications of HZ.

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Authors: Dworkin, R. H., Johnson, R. W., Breuer, J., Gnann, J. W., Levin, M. J., Backonja, M., Betts, R. F., Gershon, A. A., Haanpää, M. L., McKendrick, M. W., Nurmikko, T. J., Oaklander, A. L., Oxman, M. N., Langston, D. P., Petersen, K. L., Rowbotham, M. C., Schmader, K. E., Stacey, B. R., Tyring, S. K., Wijck, A. J. M. V., Wallace, M. S., Wassilew, S. W., & Whitley, R. J.
Affiliations: University of Rochester Medicine (US)
University of Bristol (GB)
Queen Mary University of London (GB)
Birmingham VA Medical Center (US)
University of Colorado Denver (US)
Columbia University (US)
Helsinki University Hospital (FI)
Royal Hallamshire Hospital (GB)
University of Liverpool (GB)
Harvard University (US)
University of California San Diego (US)
University of California, San Francisco (US)
Duke University (US)
The University of Texas Health Science Center at Houston (US)
Utrecht University (NL)
Helios Klinikum Krefeld (DE)
University of Alabama at Birmingham (US)
Corresponding author: Dworkin, Robert H.
ORCID: Dworkin, Robert H.
Johnson, Robert W.
Breuer, Judith
Levin, Myron J.
Gershon, Anne A.
Haanpää, Maija L.
Nurmikko, Turo J.
Oaklander, Anne Louise
Petersen, Karin L.
Schmader, Kenneth E.
Tyring, Stephen K.
Wijck, Albert J. M. van
Wallace, Mark S.
Whitley, Richard J.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2007-01-01
Volume: 44
Issue: Supplement_1
Pages: S1-S26
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/510206
OpenAlex: W2104761404
Cited by: 869
References: 253
Citations by year: 2026: 34 · 2025: 39 · 2024: 48 · 2023: 51 · 2022: 51 · 2021: 46 · 2020: 46 · 2019: 37 · 2018: 48 · 2017: 52 · 2016: 43 · 2015: 46 · 2014: 50 · 2013: 52 · 2012: 43
FWCI: 24.59
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Keywords: herpes zoster, antiviral therapy, acyclovir, brivudin, famciclovir, valacyclovir, first-line therapy, postherpetic neuralgia, treatment guidelines, treatment costs, quality of life
MeSH terms: Valacyclovir, Famciclovir, Acyclovir, Analgesics, Anti-Inflammatory Agents, Antiviral Agents, Bromodeoxyuridine, Herpes Zoster, Humans, Immunocompetence, Valine, Herpesvirus 3, Human, 2-Aminopurine, Immunocompromised Host

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