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Interrelationships among Quantity of Human Cytomegalovirus (HCMV) DNA in Blood, Donor‐Recipient Serostatus, and Administration of Methylprednisolone as Risk Factors for HCMV Disease following Liver Transplantation
Abstract
Longitudinal analysis of 162 liver transplant recipients identified 51 patients who were viremic. Virus load was determined in 47 of these patients using quantitative-competitive polymerase chain reaction. Peak virus load was significantly higher in 20 symptomatic patients than 27 asymptomatic patients (P < .0001). Elevated virus load, donor seropositivity, and total methylprednisolone dosage were risk factors for human cytomegalovirus (HCMV) disease (odds ratio [OR], 2.22/0.25 log10 increase in virus load, P = .001; OR, 4.11, P = .05; OR, 1.30/1-g increment in methylprednisolone, P = .01). Methylprednisolone and virus load were independent risk factors in a multivariate analysis (OR, 2.70/1-g increase, P = .003; OR, 1.61/0.25 log10 increase, P = .03, respectively). Virus loads of 10(4.75)-10(5.25) genomes/mL of blood were associated with an increased disease probability; the latter was shifted to lower virus loads with increasing quantities of methylprednisolone. These data illustrate the central role of virus load in HCMV pathogenesis.
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Citations
Cited by
The pathogenesis of human cytomegalovirus
Griffiths, P., Baraniak, I., & Reeves, M. (2015) · The Journal of Pathology · doi:10.1002/path.4437 · Cited by 592
Self-citationQuantitation of Cytomegalovirus: Methodologic Aspects and Clinical Applications
Boeckh, M., & Boivin, G. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.3.533 · Cited by 438
Griffiths, P. D., Stanton, A., McCarrell, E., Smith, C., Osman, M., Harber, M., Davenport, A., Jones, G., Wheeler, D. C., O'Beirne, J., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60136-0 · Cited by 389
Self-citationManifestations of Human Cytomegalovirus Infection: Proposed Mechanisms of Acute and Chronic Disease
Britt, W. (2008) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-540-77349-8_23 · Cited by 345
Clinical significance of low cytomegalovirus DNA levels in human plasma
Waggoner, J., Ho, D. Y., Libiran, P., & Pinsky, B. A. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.06800-11 · Cited by 38
Metadata
- Authors
- Cope, A. V., Sabin, C., Burroughs, A., Rolles, K., Griffiths, P. D., & Emery, V. C.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-12
- Volume
- 176
- Issue
- 6
- Pages
- 1484-1490
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2146339219
- Cited by
- 203
- References
- 0
- FWCI
- 10.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Interrelationships among Quantity of Human Cytomegalovirus (HCMV) DNA in Blood, Donor‐Recipient Serostatus, and Administration of Methylprednisolone as Risk Factors for HCMV Disease following Liver Transplantation. https://app.cochat.ai/papers/10.1086/514145
- The paper
- Cope, A. V., Sabin, C., Burroughs, A., Rolles, K., Griffiths, P. D., & Emery, V. C. (1997). Interrelationships among Quantity of Human Cytomegalovirus (HCMV) DNA in Blood, Donor‐Recipient Serostatus, and Administration of Methylprednisolone as Risk Factors for HCMV Disease following Liver Transplantation. The Journal of Infectious Diseases. https://doi.org/10.1086/514145
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