The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
The pathogenesis of human cytomegalovirus
Open accessAbstract
Human cytomegalovirus (HCMV) is a recognized cause of disease in the fetus, the allograft recipient and AIDS patients. More recently, it has been recognized as a pathogen for those admitted to intensive care units, for the elderly and for the general population. The epidemiology and molecular and cellular pathology of this virus are summarized to provide an overarching model of pathogenesis, able to account for these varying clinical presentations. In brief, HCMV has the potential to spread in the bloodstream to all organs, but only produces overt disease if the viral load increases to high levels. This is normally prevented by a robust immune response, so that the infected individual usually remains asymptomatic. However, this benefit comes at the cost of committing more and more immunological resources to controlling HCMV with time, so that the overall function of the immune system is impaired. Fortunately, recent progress in developing novel antiviral drugs and vaccines suggests the possibility that the diverse effects of HCMV may soon become controllable at the individual and population level, respectively. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Cites
Review and meta‐analysis of the epidemiology of congenital cytomegalovirus (CMV) infection
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Vaccine Prevention of Maternal Cytomegalovirus Infection
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Coding potential of laboratory and clinical strains of human cytomegalovirus
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Cited by
Estimation of the worldwide seroprevalence of cytomegalovirus: A systematic review and meta‐analysis
Zuhair, M., Smit, G. S. A., Wallis, G., Jabbar, F., Smith, C., Devleesschauwer, B., & Griffiths, P. (2019) · Reviews in Medical Virology · doi:10.1002/rmv.2034 · Cited by 889
Self-citationTargeted protein degradation: advances in drug discovery and clinical practice
Zhong, G., Chang, X., Xie, W., & Zhou, X. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02004-x · Cited by 326
Dick, J. E., Hilterbrand, A. T., Boika, A., Upton, J. W., & Bard, A. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504294112 · Cited by 166
Role of immunogenetics in the outcome of HCMV infection: implications for ageing
Aiello, A., Accardi, G., Candore, G., Caruso, C., Colomba, C., Di Bona, D., Duro, G., Gambino, C. M., Ligotti, M. E., & Pandey, J. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030685 · Cited by 38
Metadata
- Authors
- Griffiths, P., Baraniak, I., & Reeves, M.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2014-12-11
- Volume
- 235
- Issue
- 2
- Pages
- 288-297
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W1957027480
- Cited by
- 592
- References
- 72
- FWCI
- 18.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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