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Persistence and Genetic Stability of Ebola Virus during the Outbreak in Kikwit, Democratic Republic of the Congo, 1995
Abstract
Ebola virus persistence was examined in body fluids from 12 convalescent patients by virus isolation and reverse transcription-polymerase chain reaction (RT-PCR) during the 1995 Ebola hemorrhagic fever outbreak in Kikwit, Democratic Republic of the Congo. Virus RNA could be detected for up to 33 days in vaginal, rectal, and conjunctival swabs of 1 patient and up to 101 days in the seminal fluid of 4 patients. Infectious virus was detected in 1 seminal fluid sample obtained 82 days after disease onset. Sequence analysis of an RT-PCR fragment of the most variable region of the glycoprotein gene amplified from 9 patients revealed no nucleotide changes. The patient samples were selected so that they would include some from a suspected line of transmission with at least three human-to-human passages, some from 5 survivors and 4 deceased patients, and 2 from patients who provided multiple samples through convalescence. There was no evidence of different virus variants cocirculating during the outbreak or of genetic variation accumulating during human-to-human passage or during prolonged persistence in individual patients.
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Cited by
Amman, B. R., Carroll, S. A., Reed, Z. D., Sealy, T. K., Balinandi, S., Swanepoel, R., Kemp, A., Erickson, B. R., Comer, J. A., Campbell, S., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002877 · Cited by 453
Self-citationTreatment of Ebola Hemorrhagic Fever with Blood Transfusions from Convalescent Patients
Mupapa, K., Massamba, M., Kibadi, K., Kuvula, K., Bwaka, A., Kipasa, M., Colebunders, R., Muyembe‐Tamfum, J. J., & the International Scientific and Technical Committee (1999) · The Journal of Infectious Diseases · doi:10.1086/514298 · Cited by 420
The evolution of Ebola virus: Insights from the 2013-2016 epidemic
Holmes, E. C., Dudas, G., Rambaut, A., & Andersen, K. G. (2016) · Nature · doi:10.1038/nature19790 · Cited by 314
Marburg Hemorrhagic Fever Associated with Multiple Genetic Lineages of Virus
Bausch, D. G., Nichol, S. T., Muyembe-Tamfum, J. J., Borchert, M., Rollin, P. E., Sleurs, H., Campbell, P., Tshioko, F. K., Roth, C., Colebunders, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051465 · Cited by 307
Self-citationMolecular Evolution of Viruses of the Family Filoviridae Based on 97 Whole-Genome Sequences
Carroll, S. A., Towner, J. S., Sealy, T. K., McMullan, L. K., Khristova, M. L., Burt, F. J., Swanepoel, R., Rollin, P. E., & Nichol, S. T. (2013) · Journal of Virology · doi:10.1128/jvi.03118-12 · Cited by 177
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Metadata
- Authors
- Rodriguez, L. L., De Roo, A., Guimard, Y., Trappier, S. G., Sanchez, A., Bressler, D., Williams, A. J., Rowe, A. K., Bertolli, J., Khan, A. S., Ksiazek, T. G., Peters, C. J., & Nichol, S. T.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02
- Volume
- 179
- Issue
- s1
- Pages
- S170-S176
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2097378446
- Cited by
- 311
- References
- 0
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rodriguez, L. L., De Roo, A., Guimard, Y., Trappier, S. G., Sanchez, A., Bressler, D., Williams, A. J., Rowe, A. K., Bertolli, J., Khan, A. S., Ksiazek, T. G., Peters, C. J., & Nichol, S. T. (1999). Persistence and Genetic Stability of Ebola Virus during the Outbreak in Kikwit, Democratic Republic of the Congo, 1995. The Journal of Infectious Diseases. https://doi.org/10.1086/514291
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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