The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Treatment of Ebola Hemorrhagic Fever with Blood Transfusions from Convalescent Patients
Abstract
Between 6 and 22 June 1995, 8 patients in Kikwit, Democratic Republic of the Congo, who met the case definition used in Kikwit for Ebola (EBO) hemorrhagic fever, were transfused with blood donated by 5 convalescent patients. The donated blood contained IgG EBO antibodies but no EBO antigen. EBO antigens were detected in all the transfusion recipients just before transfusion. The 8 transfused patients had clinical symptoms similar to those of other EBO patients seen during the epidemic. All were seriously ill with severe asthenia, 4 presented with hemorrhagic manifestations, and 2 became comatose as their disease progressed. Only 1 transfused patient (12.5%) died; this number is significantly lower than the overall case fatality rate (80%) for the EBO epidemic in Kikwit and than the rates for other EBO epidemics. The reason for this low fatality rate remains to be explained. The transfused patients did receive better care than those in the initial phase of the epidemic. Plans should be made to prepare for a more thorough evaluation of passive immune therapy during a new EBO outbreak.
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Cites
The Reemergence of Ebola Hemorrhagic Fever, Democratic Republic of the Congo, 1995
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Isolation and Phylogenetic Characterization of Ebola Viruses Causing Different Outbreaks in Gabon
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Cited by
(2020) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap-200220-0773 · Cited by 486
Exotic emerging viral diseases: progress and challenges
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Passive immunity in prevention and treatment of infectious diseases
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Barro, L., Drew, V. J., Poda, G. G., Tagny, C. T., El‐Ekiaby, M., Owusu‐Ofori, S., & Burnouf, T. (2018) · Vox Sanguinis · doi:10.1111/vox.12705 · Cited by 92
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Metadata
- Authors
- Mupapa, K., Massamba, M., Kibadi, K., Kuvula, K., Bwaka, A., Kipasa, M., Colebunders, R., Muyembe‐Tamfum, J. J., & the International Scientific and Technical Committee
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02
- Volume
- 179
- Issue
- s1
- Pages
- S18-S23
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2130063921
- Cited by
- 420
- References
- 12
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mupapa, K., Massamba, M., Kibadi, K., Kuvula, K., Bwaka, A., Kipasa, M., Colebunders, R., Muyembe‐Tamfum, J. J., & the International Scientific and Technical Committee. (1999). Treatment of Ebola Hemorrhagic Fever with Blood Transfusions from Convalescent Patients. The Journal of Infectious Diseases. https://doi.org/10.1086/514298
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