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Clinical Virology of Ebola Hemorrhagic Fever (EHF): Virus, Virus Antigen, and IgG and IgM Antibody Findings among EHF Patients in Kikwit, Democratic Republic of the Congo, 1995
Abstract
Ebola hemorrhagic fever (EHF) patients treated at Kikwit General Hospital during the 1995 outbreak were tested for viral antigen, IgG and IgM antibody, and infectious virus. Viral antigen could be detected in virtually all patients during the acute phase of illness, while antibody was not always detectable before death. Virus was also isolated from patients during the course of their febrile illness, but attempts to quantify virus in Vero E6 cells by standard plaque assay were often unsuccessful. IgG and IgM antibody appeared at approximately the same time after disease onset (8-10 days), but IgM persisted for a much shorter period among the surviving convalescent patients. IgG antibody was detectable in surviving patients through about 2 years after onset, the latest time that samples were obtained. Detection of Ebola virus antigens or virus isolation appears to be the most reliable means of diagnosis for patients with suspected acute EHF, since patients with this often-fatal disease (80% mortality) may not develop detectable antibodies before death.
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Cited by
Sissoko, D., Laouenan, C., Folkesson, E., M’Lebing, A.-B., Beavogui, A.-H., Baize, S., Camara, A.-M., Maes, P., Shepherd, S., Danel, C., et al. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1001967 · Cited by 478
Treatment of Ebola Hemorrhagic Fever with Blood Transfusions from Convalescent Patients
Mupapa, K., Massamba, M., Kibadi, K., Kuvula, K., Bwaka, A., Kipasa, M., Colebunders, R., Muyembe‐Tamfum, J. J., & the International Scientific and Technical Committee (1999) · The Journal of Infectious Diseases · doi:10.1086/514298 · Cited by 420
Marburg Hemorrhagic Fever Associated with Multiple Genetic Lineages of Virus
Bausch, D. G., Nichol, S. T., Muyembe-Tamfum, J. J., Borchert, M., Rollin, P. E., Sleurs, H., Campbell, P., Tshioko, F. K., Roth, C., Colebunders, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa051465 · Cited by 307
Self-citationFaye, O., Boëlle, P.-Y., Heleze, E., Faye, O., Loucoubar, C., Magassouba, N., Soropogui, B., Keita, S., Gakou, T., Bah, E. H. I., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)71075-8 · Cited by 220
Persistent infection with Ebola virus under conditions of partial immunity
Gupta, M., Mahanty, S., Greer, P., Towner, J. S., Shieh, W.-J., Zaki, S. R., Ahmed, R., & Rollin, P. E. (2004) · Journal of Virology · doi:10.1128/jvi.78.2.958-967.2004 · Cited by 85
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Metadata
- Authors
- Ksiazek, T. G., Rollin, P. E., Williams, A. J., Bressler, D. S., Martin, M. L., Swanepoel, R., Burt, F. J., Leman, P. A., Khan, A. S., Rowe, A. K., Mukunu, R., Sanchez, A., & Peters, C. J.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02
- Volume
- 179
- Issue
- s1
- Pages
- S177-S187
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2094644220
- Cited by
- 359
- References
- 0
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Clinical Virology of Ebola Hemorrhagic Fever (EHF): Virus, Virus Antigen, and IgG and IgM Antibody Findings among EHF Patients in Kikwit, Democratic Republic of the Congo, 1995. https://app.cochat.ai/papers/10.1086/514321
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- Ksiazek, T. G., Rollin, P. E., Williams, A. J., Bressler, D. S., Martin, M. L., Swanepoel, R., Burt, F. J., Leman, P. A., Khan, A. S., Rowe, A. K., Mukunu, R., Sanchez, A., & Peters, C. J. (1999). Clinical Virology of Ebola Hemorrhagic Fever (EHF): Virus, Virus Antigen, and IgG and IgM Antibody Findings among EHF Patients in Kikwit, Democratic Republic of the Congo, 1995. The Journal of Infectious Diseases. https://doi.org/10.1086/514321
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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