Prophylaxis with Weekly Versus Daily Fluconazole for Fungal Infections in Patients with AIDS
Abstract
We compared the efficacy of a 400-mg once-weekly dosage versus a 200-mg daily dosage of fluconazole for the prevention of deep fungal infections in a multicenter, randomized, double-blind trial of 636 human immunodeficiency virus-infected patients to determine if a less intensive fluconazole regimen could prevent these serious but relatively infrequent complications of AIDS. In the intent-to-treat analysis, a deep fungal infection developed in 17 subjects (5.5%) randomly assigned to daily fluconazole treatment and in 24 (7.7%) given weekly fluconazole during 74 weeks of follow-up (risk difference, 2.2%; 95% confidence interval [CI], -1.7% to 6.1%). Thrush occurred twice as frequently in the weekly versus daily fluconazole recipients (hazard ratio, 0.59; 95% CI, 0.40-0.89), and in a subset of patients evaluated, fluconazole resistance was infrequent. Fluconazole administered once weekly is effective in reducing deep fungal infections in patients with AIDS, but this dosage is less effective than the 200-mg-daily dosage in preventing thrush.
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Long-term suppressive therapy with fluconazole is effective in prevention of oropharyngeal candidiasis in patients with AIDS and patients with cancer.
“Long-term suppressive therapy with fluconazole is effective in the prevention of oropharyngeal candidiasis in patients with AIDS [32,[261][262][263] and patients with cancer [264].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [262]
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- Authors
- Havlir, D. V., Dubé, M. P., McCutchan, J. A., Forthal, D. N., Kemper, C. A., Dunne, M. W., Parenti, D. M., Kumar, P. N., White, A. C., Witt, M. D., Nightingale, S. D., Sepkowitz, K. A., MacGregor, R. R., Cheeseman, S. H., Torriani, F. J., Zelasky, M. T., Sattler, F. R., & Bozzette, S. A.
- Affiliations
- University of California San Diego (US)
- United States Department of Veterans Affairs (US)
- ORCID
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-12-01
- Volume
- 27
- Issue
- 6
- Pages
- 1369-1375
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2128305340
- Cited by
- 72
- References
- 28
- Citations by year
- 2019: 1 · 2018: 3 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 4.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Keywords
- fluconazole, prophylaxis, AIDS, HIV infection, deep fungal infection, weekly dosing, daily dosing, thrushes, oral candidiasis, antifungal resistance
- MeSH terms
- Adolescent, Adult, Aged, Antifungal Agents, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Mycoses, Fluconazole, Survival Analysis, AIDS-Related Opportunistic Infections, Chemoprevention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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