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A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever
Open accessAbstract
The Zaire subtype of Ebola virus (EBO-Z) is lethal for newborn mice, but adult mice are resistant to the virus, which prevents their use as an animal model of lethal Ebola infection. We serially passed EBO-Z virus in progressively older suckling mice, eventually obtaining a plaque-purified virus that was lethal for mature, immunocompetent BALB/c and C57BL/6 inbred and ICR (CD-1) outbred mice. Pathologic changes in the liver and spleen of infected mice resembled those in EBO-Z-infected primates. Virus titers in these tissues reached 10(9) pfu/g. The LD50 of mouse-adapted EBO-Z virus inoculated into the peritoneal cavity was approximately 1 virion. Mice were resistant to large doses of the same virus inoculated subcutaneously, intradermally, or intramuscularly. Mice injected peripherally with mouse-adapted or intraperitoneally with non-adapted EBO-Z virus resisted subsequent challenge with mouse-adapted virus.
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Cited by
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Sakurai, Y., Kolokoltsov, A. A., Chen, C.-C., Tidwell, M. W., Bauta, W. E., Klugbauer, N., Grimm, C., Wahl-Schott, C., Biel, M., & Davey, R. A. (2015) · Science · doi:10.1126/science.1258758 · Cited by 555
Ebola Virus VP24 Binds Karyopherin α1 and Blocks STAT1 Nuclear Accumulation
Reid, S. P., Leung, L. W., Hartman, A. L., Martinez, O., Shaw, M. L., Carbonnelle, C., Volchkov, V. E., Nichol, S. T., & Basler, C. F. (2006) · Journal of Virology · doi:10.1128/jvi.02349-05 · Cited by 463
Wauquier, N., Becquart, P., Padilla, C., Baize, S., & Leroy, E. M. (2010) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0000837 · Cited by 377
Saphire, E. O., Schendel, S. L., Fusco, M. L., Gangavarapu, K., Gunn, B. M., Wec, A. Z., Halfmann, P. J., Brannan, J. M., Herbert, A. S., Qiu, X., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.033 · Cited by 212
Metadata
- Authors
- Bray, M., Davis, K., Geisbert, T., Schmaljohn, C., & Huggins, J.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-09
- Volume
- 178
- Issue
- 3
- Pages
- 651-661
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2121706409
- Cited by
- 492
- References
- 0
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever. https://app.cochat.ai/papers/10.1086/515386
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- Bray, M., Davis, K., Geisbert, T., Schmaljohn, C., & Huggins, J. (1998). A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever. The Journal of Infectious Diseases. https://doi.org/10.1086/515386
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
