Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

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Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

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Identification of a novel coronavirus in patients with severe acute respiratory syndrome

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A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

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Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

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A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong

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Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

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Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China

Guan, Y., Zheng, B., He, Y., Liu, X. L., Zhuang, Z. X., Cheung, C. L., Luo, S., Li, P. H., Zhang, L., Guan, Y., et al. (2003) · Science · doi:10.1126/science.1087139 · Cited by 2,404 · see citing works

Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study

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The Genome Sequence of the SARS-Associated Coronavirus

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Identification of a new human coronavirus

van der Hoek, L., Pyrć, K., Jebbink, M. F., Vermeulen-Oost, W., Berkhout, R. J. M., Wolthers, K. C., Dillen, P. M. E. W., Kaandorp, J. C., Spaargaren, J., & Berkhout, B. (2004) · Nature Medicine · doi:10.1038/nm1024 · Cited by 1,868 · see citing works

Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings

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Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003

Zhong, N., Zheng, B., Li, Y., Poon, L., Xie, Z., Chan, K., Li, P. H., Tan, S., Chang, Q., Xie, J., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14630-2 · Cited by 1,578 · see citing works

Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia

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The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex

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Clinical Features and Short-term Outcomes of 144 Patients With SARS in the Greater Toronto Area

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Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 Lineage

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Severe acute respiratory syndrome

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Lung pathology of fatal severe acute respiratory syndrome

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IFN-γ-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking

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Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathways

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Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

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Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome

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The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

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Receptor and viral determinants of SARS‐coronavirus adaptation to human ACE2

Li, W., Zhang, C., Sui, J., Kuhn, J. H., Moore, M. J., Luo, S., Wong, S.-K., Huang, I., Xu, K., Vasilieva, N. Y., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600640 · Cited by 976 · see citing works

Use of convalescent plasma therapy in SARS patients in Hong Kong

Cheng, Y., Wong, R. S. M., Soo, Y. O. Y., Wong, W. S., Lee, C. K., Ng, M. H. L., Chan, P. K. S., Wong, K. C., Leung, C. B., & Cheng, G. Y.-M. (2004) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-004-1271-9 · Cited by 953 · see citing works

Human aminopeptidase N is a receptor for human coronavirus 229E

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Mechanisms and enzymes involved in SARS coronavirus genome expression

Thiel, V., Ivanov, K. A., Putics, Á., Hertzig, T., Schelle, B., Bayer, S., Weißbrich, B., Snijder, E. J., Rabenau, H. F., Doerr, H. W., et al. (2003) · Journal of General Virology · doi:10.1099/vir.0.19424-0 · Cited by 843 · see citing works

Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry

Hofmann, H., Pyrc, K., van der Hoek, L., Geier, M., Berkhout, B., & Pöhlmann, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409465102 · Cited by 824 · see citing works

Koch's postulates fulfilled for SARS virus

Fouchier, R. A. M., Kuiken, T., Schutten, M., van Amerongen, G., van Doornum, G. J. J., van den Hoogen, B. G., Peiris, M. J. S., Lim, W. W. L., Stöhr, K., & Osterhaus, A. D. M. E. (2003) · Nature · doi:10.1038/423240a · Cited by 790 · see citing works

Human and avian influenza viruses target different cell types in cultures of human airway epithelium

Matrosovich, M. N., Matrosovich, T. Y., Gray, T. E., Roberts, N. A., & Klenk, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308001101 · Cited by 777 · see citing works

Molecular Evolution of the SARS Coronavirus During the Course of the SARS Epidemic in China

The Chinese SARS Molecular Epidemiology Consortium (2004) · Science · doi:10.1126/science.1092002 · Cited by 765 · see citing works

The clinical pathology of severe acute respiratory syndrome (SARS): a report from China

Ding, Y., Wang, H., Shen, H., Li, Z., Geng, J., Han, H.-X., Cai, J., Li, X., Kang, W., Weng, D., et al. (2003) · The Journal of Pathology · doi:10.1002/path.1440 · Cited by 765 · see citing works

Coronavirus Genome Structure and Replication

Brian, D. A., & Baric, R. S. (2005) · Current topics in microbiology and immunology · doi:10.1007/3-540-26765-4_1 · Cited by 758 · see citing works

Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection

Leung, W. K., To, K., Chan, P. K. S., Chan, H. L., Wu, A. K. L., Lee, N. L. S., Yuen, K., & Sung, J. J. �. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)01215-0 · Cited by 697 · see citing works

An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus

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A 193-Amino Acid Fragment of the SARS Coronavirus S Protein Efficiently Binds Angiotensin-converting Enzyme 2

Wong, S. K., Li, W., Moore, M. J., Choe, H., & Farzan, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300520200 · Cited by 690 · see citing works

A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice

Yang, Z.-Y., Kong, W., Huang, Y., Roberts, A., Murphy, B., Subbarao, K., & Nabel, G. (2004) · Nature · doi:10.1038/nature02463 · Cited by 688 · see citing works

Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human

Song, H., Tu, C., Zhang, G., Wang, S., Zheng, K. C., Lei, L., Chen, Q., Gao, Y., Zhou, H., Xiang, H., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409608102 · Cited by 683 · see citing works

Coronavirus Spike Proteins in Viral Entry and Pathogenesis

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CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus

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A previously undescribed coronavirus associated with respiratory disease in humans

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SARS virus infection of cats and ferrets

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Haematological manifestations in patients with severe acute respiratory syndrome: retrospective analysis

Wong, R., Wu, A., To, K.-F., Lee, N., Lam, C., Wong, C., Chan, P. K., Ng, M., Yu, L., Hui, D., et al. (2003) · British medical journal · doi:10.1136/bmj.326.7403.1358 · Cited by 566 · see citing works

Hemophagocytic Syndromes and Infection

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Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry

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In vitro susceptibility of 10 clinical isolates of SARS coronavirus to selected antiviral compounds

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Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors

Liu, S., Xiao, G., Chen, Y., He, Y., Niu, J., Escalante, C. R., Xiong, H., Farmar, J. G., Debnath, A. K., Tien, P., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15788-7 · Cited by 503 · see citing works

Nucleocapsid-independent assembly of coronavirus-like particles by co-expression of viral envelope protein genes.

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A Mouse Model for Evaluation of Prophylaxis and Therapy of Ebola Hemorrhagic Fever

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pH-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus Is Mediated by the Spike Glycoprotein and Enhanced by Dendritic Cell Transfer through DC-SIGN

Yang, Z., Huang, Y. M., Lakshmanan, G., Leung, K., Kong, W., Schwartz, O., Subbarao, K., & Nabel, G. J. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5642-5650.2004 · Cited by 488 · see citing works

The Ebola virus VP35 protein functions as a type I IFN antagonist

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Treatment of SARS with human interferons

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Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells

Law, H., Cheung, C. Y., Ng, H. Y., Sia, S. F., Chan, Y. O., Luk, W., Nicholls, J. M., Peiris, M. J. S., & Lau, Y. (2005) · Blood · doi:10.1182/blood-2004-10-4166 · Cited by 467 · see citing works

Cytokine Responses in Severe Acute Respiratory Syndrome Coronavirus-Infected Macrophages In Vitro: Possible Relevance to Pathogenesis

Cheung, C. Y., Poon, L. L. M., Ng, I. H. Y., Luk, W., Sia, S. F., Wu, M. H. S., Chan, K., Yuen, K., Gordon, S., Guan, Y., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7819-7826.2005 · Cited by 461 · see citing works

Suppression of the Induction of Alpha, Beta, and Gamma Interferons by the NS1 and NS2 Proteins of Human Respiratory Syncytial Virus in Human Epithelial Cells and Macrophages

Spann, K. M., Tran, K.-C., Chi, B., Rabin, R. L., & Collins, P. L. (2004) · Journal of Virology · doi:10.1128/jvi.78.8.4363-4369.2004 · Cited by 447 · see citing works

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

Li, B.-J., Tang, Q., Cheng, D., Qin, C., Xie, F. Y., Wei, Q., Xu, J., Liu, Y., Zheng, B.-J., Woodle, M. C., et al. (2005) · Nature Medicine · doi:10.1038/nm1280 · Cited by 433 · see citing works

Pathology of fatal human infection associated with avian influenza A H5N1 virus

To, K., Chan, P. K. S., Chan, K.-F., Lee, W.-K., Lam, W.-Y., Wong, K.-F., Tang, N. L. S., Tsang, D. N. C., Sung, R. Y. T., Buckley, T. A., et al. (2001) · Journal of Medical Virology · doi:10.1002/1096-9071(200103)63:3 · Cited by 422 · see citing works

Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides

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Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice

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Inhibition of genes expression of SARS coronavirus by synthetic small interfering RNAs

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Redefined Nomenclature for Members of the Carcinoembryonic Antigen Family

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Prior Infection and Passive Transfer of Neutralizing Antibody Prevent Replication of Severe Acute Respiratory Syndrome Coronavirus in the Respiratory Tract of Mice

Subbarao, K., McAuliffe, J. M., Vogel, L., Fahle, G. A., Fischer, S. H., Tatti, K. M., Packard, M. M., Shieh, W., Zaki, S. R., & Murphy, B. R. (2004) · Journal of Virology · doi:10.1128/jvi.78.7.3572-3577.2004 · Cited by 397 · see citing works

Association between a Novel Human Coronavirus and Kawasaki Disease

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Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

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Identification of a Novel Coronavirus in Bats

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The Coronavirus Replicase

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Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome

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Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity

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Pegylated interferon-α protects type 1 pneumocytes against SARS coronavirus infection in macaques

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A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae

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A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN

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The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase

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Retargeting of Coronavirus by Substitution of the Spike Glycoprotein Ectodomain: Crossing the Host Cell Species Barrier

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Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses.

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Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets

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Characterization of the budding compartment of mouse hepatitis virus: evidence that transport from the RER to the Golgi complex requires only one vesicular transport step

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