The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Immunologic Responses Associated with 12 Weeks of Combination Antiretroviral Therapy Consisting of Zidovudine, Lamivudine, and Ritonavir: Results of AIDS Clinical Trials Group Protocol 315
Open accessAbstract
Human immunodeficiency virus (HIV)-1 infection is associated with progressive cell-mediated immune deficiency and abnormal immune activation. Although highly active antiretroviral therapy regimens can increase circulating CD4 T lymphocyte counts and decrease the risk of opportunistic complications, the effects of these treatments on immune reconstitution are not well understood. In 44 persons with moderately advanced HIV-1 infection, after 12 weeks of treatment with zidovudine, lamivudine, and ritonavir, plasma HIV-1 RNA fell a median of 2.3 logs (P < .0001). Circulating numbers of naive and memory CD4 T lymphocytes (P < .001), naive CD8 T lymphocytes (P < .004), and B lymphocytes (P < .001) increased. Improved lymphocyte proliferation to certain antigens and a tendency to improvement in delayed-type hypersensitivity also were seen. Dysregulated immune activation was partially corrected by this regimen; however, the perturbed expression of T cell receptor V regions in the CD4 and CD8 T lymphocyte populations was not significantly affected. Ongoing studies will ascertain if longer durations of virus suppression will permit more complete immune restoration.
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HIV-1 Antiretroviral Drug Therapy
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HIV Reservoirs and Treatment Strategies toward Curing HIV Infection
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Metadata
- Authors
- Lederman, M. M., Connick, E., Landay, A., Kuritzkes, D. R., Spritzler, J., St. Clair, M., Kotzin, B. L., Fox, L., Heath Chiozzi, M., Leonard, J. M., Rousseau, F., Wade, M., Roe, J. D., Martinez, A., & Kessler, H.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-07-01
- Volume
- 178
- Issue
- 1
- Pages
- 70-79
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2121956497
- Cited by
- 425
- References
- 32
- FWCI
- 13.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lederman, M. M., Connick, E., Landay, A., Kuritzkes, D. R., Spritzler, J., St. Clair, M., Kotzin, B. L., Fox, L., Heath Chiozzi, M., Leonard, J. M., Rousseau, F., Wade, M., Roe, J. D., Martinez, A., & Kessler, H. (1998). Immunologic Responses Associated with 12 Weeks of Combination Antiretroviral Therapy Consisting of Zidovudine, Lamivudine, and Ritonavir: Results of AIDS Clinical Trials Group Protocol 315. Journal of Infectious Diseases. https://doi.org/10.1086/515591
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