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Quinolone‐Resistant Salmonella typhi in Viet Nam: Molecular Basis of Resistance and Clinical Response to Treatment
Open accessAbstract
Nalidixic acid-resistant Salmonella typhi (NARST) was first isolated in Viet Nam in 1993. Analysis of the quinolone resistance-determining region of gyrA in 20 NARST isolates by polymerase chain reaction and single-stranded conformational polymorphism yielded two novel patterns: pattern II corresponding to a point mutation at nucleotide 87 Asp-->Gly (n = 17), and pattern III corresponding to a point mutation at nucleotide 83 Ser-->Phe (n = 3). In trials of short-course ofloxacin therapy for uncomplicated typhoid, 117 (78%) of 150 patients were infected with multidrug-resistant S. typhi, 18 (15%) of which were NARST. The median time to fever clearance was 156 hours (range, 30-366 hours) for patients infected with NARST and 84 hours (range, 12-378 hours) for those infected with nalidixic acid-susceptible strains (P < .001). Six (33.3%) of 18 NARST infections required retreatment, whereas 1 (0.8%) of 132 infections due to susceptible strains required retreatment (relative risk = 44; 95% confidence interval = 5.6-345; P < .0001). We recommend that short courses of quinolones not be used in patients infected with NARST.
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Citations
Cited by
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Self-citationParry, C. M., Hien, T. T., Dougan, G., White, N. J., & Farrar, J. J. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020201 · Cited by 1,112
Self-citationAntimicrobial resistance in developing countries. Part I: recent trends and current status
Okeke, I. N., Laxminarayan, R., Bhutta, Z. A., Duse, A. G., Jenkins, P., O'Brien, T. F., Pablos-Mendez, A., & Klugman, K. P. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70189-4 · Cited by 851
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Metadata
- Authors
- Wain, J., Hoa, N. T. T., Chinh, N. T., Vinh, H., Everett, M. J., Diep, T. S., Day, N. P. J., Solomon, T., White, N. J., Piddock, L. J. V., & Parry, C. M.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-12
- Volume
- 25
- Issue
- 6
- Pages
- 1404-1410
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2107880730
- Cited by
- 331
- References
- 0
- FWCI
- 31.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Quinolone‐Resistant Salmonella typhi in Viet Nam: Molecular Basis of Resistance and Clinical Response to Treatment. https://app.cochat.ai/papers/10.1086/516128
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- Wain, J., Hoa, N. T. T., Chinh, N. T., Vinh, H., Everett, M. J., Diep, T. S., Day, N. P. J., Solomon, T., White, N. J., Piddock, L. J. V., & Parry, C. M. (1997). Quinolone‐Resistant Salmonella typhi in Viet Nam: Molecular Basis of Resistance and Clinical Response to Treatment. Clinical Infectious Diseases. https://doi.org/10.1086/516128
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