The DOI matches its Crossref record.
High Prevalence of Chlamydia pneumoniae DNA in Peripheral Blood Mononuclear Cells in Patients with Cardiovascular Disease and in Middle‐Aged Blood Donors
Abstract
Nested polymerase chain reaction (nPCR) demonstrated the presence of Chlamydia pneumoniae-specific DNA in peripheral blood mononuclear cells (PBMC). PBMC samples were obtained from 103 consecutive patients (62 male, 41 female) aged 22-85 years (mean, 64) admitted for coronary angiography because of suspected coronary heart disease and from 52 blood donors (43 male, 9 female) aged 40-64 years (mean, 49). Of the 101 evaluable patients, 60 (59%) were identified by nPCR assay as C. pneumoniae DNA carriers; C. pneumoniae-specific microimmunofluorescence (MIF) serology confirmed exposure to the bacterium in 57 (95%) of the 60 nPCR-positive patients. Among the 52 blood donors, the nPCR assay identified 24 (46%) C. pneumoniae DNA carriers, all of whom were positive by C. pneumoniae-specific serology. Thirty-two patients (32%) and 23 blood donors (44%) were MIF antibody-positive but repeatedly nPCR-negative; Bartonella henselae- or Bartonella quintana-specific antibodies were not detected among any of these subjects. In this study, C. pneumoniae DNA was common in PBMC of patients with coronary heart disease and in middle-aged blood donors.
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Citations
Cited by
C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients
Yeun, J. Y., Levine, R. A., Mantadilok, V., & Kaysen, G. A. (2000) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(00)70200-9 · Cited by 887
Chlamydia pneumoniae — an infectious risk factor for atherosclerosis?
Campbell, L. A., & Kuo, C.-C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro796 · Cited by 277
Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice
Little, C. S., Hammond, C. J., MacIntyre, A., Balin, B. J., & Appelt, D. M. (2004) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00127-1 · Cited by 243
Phagocytes transmit Chlamydia pneumoniae from the lungs to the vasculature
Gieffers, J., van Zandbergen, G., Rupp, J., Sayk, F., Krüger, S., Ehlers, S., Solbach, W., & Maass, M. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00093304 · Cited by 109
Interaction of Chlamydiae with human macrophages
Herweg, J., & Rudel, T. (2016) · The FEBS Journal · doi:10.1111/febs.13609 · Cited by 39
Metadata
- Authors
- Boman, J., Söderberg, S., Forsberg, J., Birgander, L. S., Allard, A., Persson, K., Jidell, E., Kumlin, U., Juto, P., Waldenström, A., & Wadell, G.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-07
- Volume
- 178
- Issue
- 1
- Pages
- 274-277
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2060478888
- Cited by
- 226
- References
- 0
- FWCI
- 21.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: High Prevalence of Chlamydia pneumoniae DNA in Peripheral Blood Mononuclear Cells in Patients with Cardiovascular Disease and in Middle‐Aged Blood Donors. https://app.cochat.ai/papers/10.1086/517452
- The paper
- Boman, J., Söderberg, S., Forsberg, J., Birgander, L. S., Allard, A., Persson, K., Jidell, E., Kumlin, U., Juto, P., Waldenström, A., & Wadell, G. (1998). High Prevalence of Chlamydia pneumoniae DNA in Peripheral Blood Mononuclear Cells in Patients with Cardiovascular Disease and in Middle‐Aged Blood Donors. The Journal of Infectious Diseases. https://doi.org/10.1086/517452
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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