The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Greater Tenofovir‐Associated Renal Function Decline with Protease Inhibitor–Based versus Nonnucleoside Reverse‐Transcriptase Inhibitor–Based Therapy
Open accessAbstract
BACKGROUND: Plasma concentrations of tenofovir increase when the drug is coadministered with some ritonavir-boosted protease inhibitors (PI/r). We hypothesized that tenofovir disoproxil fumarate (TDF)-treated patients taking PI/r-based regimens would have a greater decline in renal function than patients receiving nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based therapy. METHODS: We compared the estimated decline in renal function among 146 human immunodeficiency virus type 1 (HIV-1)-infected patients receiving a TDF+PI/r- (n = 51), TDF+NNRTI- (n = 29), or non-TDF-containing (n = 66) regimen. Plasma tenofovir concentrations were measured at study week 2, and rates of creatinine clearance (CrCl) were estimated using the Cockcroft-Gault (C-G) and Modification of Diet in Renal Disease (MDRD) equations. Mixed-effects models were used to analyze regimen type and tenofovir concentration as predictors of change in CrCl from baseline to weeks 24 and 48. RESULTS: Decreases in C-G estimates of CrCl were not significantly different among the 3 groups during the first 24 weeks of therapy. However, in adjusted analyses, patients receiving TDF+PI/r had a greater rate of decline in CrCl than did the TDF+NNRTI group (for C-G, -13.9 vs. -6.2 mL/min/year [P = .03]; for MDRD, -14.7 vs. -4.5 mL/min/1.73 m(2)/year [P = .02]). Among TDF-treated patients, tenofovir plasma concentration was not associated with CrCl over time. CONCLUSIONS: Treatment with TDF and PI/r was associated with greater declines in renal function over 48 weeks compared with TDF+NNRTI-based regimens.
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Cites
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Mechanism of Active Renal Tubular Efflux of Tenofovir
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Sax, P. E., Wohl, D., Yin, M. T., Post, F., DeJesus, E., Saag, M., Pozniak, A., Thompson, M., Podzamczer, D., Molina, J. M., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60616-x · Cited by 601
Mocroft, A., Kirk, O., Reiss, P., De Wit, S., Sedlacek, D., Beniowski, M., Gatell, J., Phillips, A. N., Ledergerber, B., & Lundgren, J. D. (2010) · AIDS · doi:10.1097/qad.0b013e328339fe53 · Cited by 406
Labarga, P., Barreiro, P., Martin-Carbonero, L., Rodriguez-Novoa, S., Solera, C., Medrano, J., Rivas, P., Albalater, M., Blanco, F., Moreno, V., et al. (2009) · AIDS · doi:10.1097/qad.0b013e3283262a64 · Cited by 294
Metadata
- Authors
- Goicoechea, M., Liu, S., Best, B., Sun, S., Jain, S., Kemper, C., Witt, M., Diamond, C., Haubrich, R., Louie, S., & California Collaborative Treatment Group 578 Team
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01
- Volume
- 197
- Issue
- 1
- Pages
- 102-108
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2142982724
- Cited by
- 299
- References
- 22
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Goicoechea, M., Liu, S., Best, B., Sun, S., Jain, S., Kemper, C., Witt, M., Diamond, C., Haubrich, R., Louie, S., & California Collaborative Treatment Group 578 Team. (2008). Greater Tenofovir‐Associated Renal Function Decline with Protease Inhibitor–Based versus Nonnucleoside Reverse‐Transcriptase Inhibitor–Based Therapy. The Journal of Infectious Diseases. https://doi.org/10.1086/524061
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