The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir
Abstract
BACKGROUND: Tenofovir (TDF) is the most widely prescribed antiretroviral drug. Kidney abnormalities are the main concern using the drug. As glomerular function is infrequently affected in patients treated with TDF, herein, we report the results of an extensive examination of tubular function. METHODS: Cross-sectional study of plasma and 24 h urine markers of kidney tubulopathy (glucosuria, hyperaminoaciduria, hyperphosphaturia, hyperuricosuria and beta2-microglobulinuria) could be allocated in three groups: patients under a TDF-containing HAART; patients on HAART never exposed to TDF; and antiretroviral-naive individuals. Significant tubular damage was defined when at least two of these parameters were repeatedly present, being at least one part of the Fanconi syndrome criteria (glucosuria, hyperaminoaciduria and hyperphosphaturia). Glomerular function was assessed using creatinine clearance. RESULTS: A total of 284 consecutive HIV patients were examined, 154 on TDF, 49 on other HAART regimens and 81 drug-naive. No significant differences in creatinine clearance were observed when comparing distinct groups. The proportion of patients with tubular damage in groups 1, 2 and 3 were 22, 6 and 12%, respectively. In a multivariate analysis [odds ratio (OR) {95% confidence interval (CI)} P], the only independent predictors of tubular dysfunction were TDF use (21.6, 4.1-113, <0.001) and older age (1.1 per year, 1.0-1.1, 0.01). CONCLUSION: Exposure to TDF is associated with an increased risk over time of kidney tubular abnormalities in the absence of significant impaired glomerular function. Although long-term consequences of this tubulopathy are unknown, close monitoring of accelerated bone mineral loss and renal insufficiency are warranted. Periodic screening of tubular function parameters should be recommended to patients receiving TDF.
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Thompson, M. A., Aberg, J. A., Hoy, J. F., Telenti, A., Benson, C., Cahn, P., Eron, J. J., Günthard, H. F., Hammer, S. M., Reiss, P., et al. (2012) · JAMA · doi:10.1001/jama.2012.7961 · Cited by 2,469
Hammer, S. M., Eron, J. J., Reiss, P., Schooley, R. T., Thompson, M. A., Walmsley, S., Cahn, P., Fischl, M. A., Gatell, J. M., Hirsch, M. S., et al. (2008) · JAMA · doi:10.1001/jama.300.5.555 · Cited by 1,026
Karras, A., Lafaurie, M., Furco, A., Bourgarit, A., Droz, D., Sereni, D., Legendre, C., Martinez, F., & Molina, J. (2003) · Clinical Infectious Diseases · doi:10.1086/368314 · Cited by 361
Nelson, M. R., Katlama, C., Montaner, J. S., Cooper, D. A., Gazzard, B., Clotet, B., Lazzarin, A., Schewe, K., Lange, J., Wyatt, C., et al. (2007) · AIDS · doi:10.1097/qad.0b013e3280b07b33 · Cited by 352
Cihlar, T., Lin, D. C., Pritchard, J. B., Fuller, M. D., Mendel, D. B., & Sweet, D. H. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23084-4 · Cited by 345
Mechanism of Active Renal Tubular Efflux of Tenofovir
Ray, A. S., Cihlar, T., Robinson, K. L., Tong, L., Vela, J. E., Fuller, M. D., Wieman, L. M., Eisenberg, E. J., & Rhodes, G. R. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00251-06 · Cited by 323
Gallant, J. E., Parish, M. A., Keruly, J. C., & Moore, R. D. (2005) · Clinical Infectious Diseases · doi:10.1086/428840 · Cited by 302
Goicoechea, M., Liu, S., Best, B., Sun, S., Jain, S., Kemper, C., Witt, M., Diamond, C., Haubrich, R., Louie, S., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/524061 · Cited by 299
Renal Tubular Dysfunction Associated With Tenofovir Therapy: Report of 7 Cases
Peyri??re, H., Reynes, J., Rouanet, I., Daniel, N., de Boever, C. M., Mauboussin, J.-M., Leray, H., Moachon, L., Vincent, D., & Salmon-C??ron, D. (2004) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200403010-00007 · Cited by 262
Association between ABCC2 Gene Haplotypes and Tenofovir‐Induced Proximal Tubulopathy
Izzedine, H., Hulot, J., Villard, E., Goyenvalle, C., Dominguez, S., Ghosn, J., Valantin, M. A., Lechat, P., & Deray, A. G. (2006) · The Journal of Infectious Diseases · doi:10.1086/508546 · Cited by 243
Cited by
Drug-Induced Acute Kidney Injury
Perazella, M. A., & Rosner, M. H. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11290821 · Cited by 357
Grohskopf, L. A., Chillag, K. L., Gvetadze, R., Liu, A. Y., Thompson, M., Mayer, K. H., Collins, B. M., Pathak, S. R., O'Hara, B., Ackers, M. L., et al. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31828ece33 · Cited by 172
Grant, P. M., & Cotter, A. G. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000248 · Cited by 165
Metadata
- Authors
- Labarga, P., Barreiro, P., Martin-Carbonero, L., Rodriguez-Novoa, S., Solera, C., Medrano, J., Rivas, P., Albalater, M., Blanco, F., Moreno, V., Vispo, E., & Soriano, V.
- Venue
- AIDS
- Published
- 2009-03-27
- Volume
- 23
- Issue
- 6
- Pages
- 689-696
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2091989309
- Cited by
- 294
- References
- 33
- FWCI
- 19.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Labarga, P., Barreiro, P., Martin-Carbonero, L., Rodriguez-Novoa, S., Solera, C., Medrano, J., Rivas, P., Albalater, M., Blanco, F., Moreno, V., Vispo, E., & Soriano, V. (2009). Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir. AIDS. https://doi.org/10.1097/qad.0b013e3283262a64
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