Preventing HIV Antiretroviral Resistance through Better Monitoring of Treatment Adherence
Abstract
Suboptimal adherence to antiretroviral therapy (ART) is the most common cause of viral rebound. Accurate and reliable measures of ART adherence will be needed in the transition from reactive response to proactive prevention of viral rebound in the era of chronic human immunodeficiency virus (HIV) disease management. Such tools could define individual "signature adherence patterns," which could inform regimen choice and guide behavioral intervention. Upcoming advances in adherence monitoring present opportunities to better match HIV-disease treatment strategies with individual adherence behavior.
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Non-adherence is the most common reason for treatment failure.
“Non-adherence is the most common reason for treatment failure,5 with potential risk to develop drug resistance through suboptimal viral suppression.”
From Determinants of adherence to antiretroviral therapy among HIV-positive adults in sub-Saharan Africa: a systematic review (2016) · cites this paper as [5]
Non-adherence can lead to drug-resistant HIV caused by failure to achieve maximal viral suppression.
“Non-adherence can lead to drug-resistant HIV caused by failure to achieve maximal viral suppression.”
From Determinants of adherence to antiretroviral therapy among HIV-positive adults in sub-Saharan Africa: a systematic review (2016) · cites this paper as [5]
Cites
Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwickl, B., Wu, A. W., & PATIENT CARE COMMITTEE & ADHERENCE (2000) · AIDS Care · doi:10.1080/09540120050042891 · Cited by 1,428 · see citing works
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Kane, J. M., Kishimoto, T., & Correll, C. U. (2013) · World Psychiatry · doi:10.1002/wps.20060 · Cited by 520 · see citing works
Heestermans, T., Browne, J. L., Aitken, S. C., Vervoort, S. C., & Klipstein-Grobusch, K. (2016) · BMJ Global Health · doi:10.1136/bmjgh-2016-000125 · Cited by 348 · see citing works
“Non-adherence is the most common reason for treat-ment failure, 5 with potential risk to develop drug resistance through suboptimal viral suppression.”
BackgroundBärnighausen, T., Chaiyachati, K., Chimbindi, N., Peoples, A., Haberer, J., & Newell, M.-L. (2011) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70181-5 · Cited by 246 · see citing works
Chang, L. W., Kagaayi, J., Arem, H., Nakigozi, G., Ssempijja, V., Serwadda, D., Quinn, T. C., Gray, R. H., Bollinger, R. C., & Reynolds, S. J. (2011) · AIDS and Behavior · doi:10.1007/s10461-011-9995-x · Cited by 184 · see citing works
- Authors
- Bangsberg, D. R.
- Affiliations
- San Francisco General Hospital (US)
- Corresponding author
- Bangsberg, David R.
- ORCID
- Bangsberg, David R.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05-15
- Volume
- 197
- Issue
- s3
- Pages
- S272-S278
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2130715578
- Cited by
- 183
- References
- 1
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 8 · 2017: 13 · 2016: 21 · 2015: 12 · 2014: 12 · 2013: 18 · 2012: 14
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Abbott Laboratories
- Bristol-Myers Squibb
- Gilead Sciences
- National Institutes of Health (5k24aa015287-03)
- Center for AIDS Research, University of Washington
- University of California, San Francisco
- National Institute on Alcohol Abuse and Alcoholism (AA015287)
- National Institute of Mental Health (MH 54907, P30MH059037, R01MH054907, P30-MH 59037)
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Keywords
- antiretroviral therapy adherence, viral rebound, adherence monitoring, treatment regimen selection, behavioral interventions, HIV prevention
- MeSH terms
- Humans, Patient Compliance, HIV-1, HIV Infections, Anti-HIV Agents, Drug Resistance, Multiple, Viral
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