CoChat
Sign Up
Cited by 142Herpesvirus Infections and TreatmentsGenital Health and DiseaseHIV/AIDS Research and Interventions

Effect of HSV-2 serostatus on acquisition of HIV by young men: results of a longitudinal study in Orange Farm, South Africa.

Open access
Sobngwi‐Tambekou, Joelle, Taljaard, Dirk, Lissouba, Pascale, Zarca, Kevin, Puren, Adrian, Lagarde, Emmanuel, Auvert, Bertran·2009·The Journal of Infectious Diseases
DOI 10.1086/597208PMC PMC2868899
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: The objectives of this study were to assess the impact among young men of herpes simplex virus type 2 (HSV-2) status on the acquisition of human immunodeficiency virus (HIV) and on the protective effect of male circumcision against HIV acquisition. METHODS: We used data collected during a male circumcision trial conducted in Orange Farm, South Africa. We estimated adjusted incidence rate ratios (IRRs) for HIV acquisition, using survival analysis and background characteristics, HSV-2 status, male circumcision status, and sexual behavior as covariates. RESULTS: Compared with subjects who remained HSV-2 negative throughout the study, subjects who were HSV-2 positive at enrollment had an adjusted IRR of 3.3 (95% confidence interval [CI], 1.5-7.4; P=.004), and those who became HSV-2 positive during follow-up had an adjusted IRR of 7.0 (95% CI, 3.9-12.4; P<.001). The population fraction of incident HIV infection attributable to HSV-2 was 27.8% (95% CI, 17.7%-37.2%). Intention-to-treat analysis of the protective effect of male circumcision on HIV acquisition was the same among men with and men without HSV-2 (0.38 vs. 0.37; P=.93). CONCLUSIONS: This study shows that HSV-2 has a substantial impact on HIV acquisition among young South African men. It suggests that HSV-2 infection enhances HIV acquisition and is responsible for approximately 25% of incident cases of HIV infection. However, the protective effect of male circumcision against HIV acquisition appears independent of HSV-2 serostatus. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00122525.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1086/597208

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In those trials, circumcision also was protective against other STIs, including high-risk genital HPV infection and genital herpes.

    “In those trials, circumcision also was protective against other STIs, including high-risk genital HPV infection and genital herpes (66–68).”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [68]

    The Results (Risk factors of HSV-2 incidence; page unavailable) report a protective effect of circumcision against HSV-2 acquisition in young men, significant in the as-treated analysis but only borderline in the intention-to-treat analysis. The paper does not report an effect on high-risk genital HPV infection, so it supports the genital-herpes portion of the sentence but not the HPV portion. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • MMC can be associated with decreased risk for HSV-2 acquisition among adult heterosexual men and with decreased risk for HSV-2 transmission from male to female partners.

    “These data indicate that MMC can be associated with decreased risk for HSV-2 acquisition among adult heterosexual men and with decreased risk for HSV-2 transmission from male to female partners.”

    From Sexually Transmitted Infections Treatment Guidelines, 2021 (2021) · cites this paper as [68]

    The Discussion reports a protective association between male circumcision and HSV-2 acquisition in young men, significant in the as-treated analysis but not the intention-to-treat analysis. It does not report reduced HSV-2 transmission from men to female partners; it discusses female-to-male transmission instead. No page numbers are provided in our copy. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [36]Connie Celum C Wald A Hughes J HSV-2 Suppressive Therapy for Prevention of HIV Acquisition: Results of HPTN 039 Abstract 31499, Presented at the 15th conference on retroviruses and opportunistic infections Boston (USA) 3–6 February 2008 2008

Cited by

Sorted by citations

Related

Authors
Sobngwi‐Tambekou, J., Taljaard, D., Lissouba, P., Zarca, K., Puren, A., Lagarde, E., & Auvert, B.
Affiliations
  • Inserm (FR)
  • National Institute for Communicable Diseases (ZA)
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2009-04
Volume
199
Issue
7
Pages
958-964
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/597208
PMC
PMC2868899
OpenAlex
W2109780373
Cited by
142
References
37
Citations by year
2026: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 12 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 15 · 2012: 14
FWCI
13.94
Type
journal article
Language
en
Open access
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion, other-oa)
Funders
  • Bill and Melinda Gates Foundation (33759)
  • Institut National de la Santé et de la Recherche Médicale
Topics
  • Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
  • Health Sciences › Medicine › Surgery › Genital Health and Disease
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords
HIV acquisition, herpes simplex virus type 2, male circumcision, HIV prevention, young men, sexual behavior, attributable fraction
MeSH terms
Adolescent, Antibodies, Viral, Circumcision, Male, Herpes Genitalis, Humans, Longitudinal Studies, Male, Risk Factors, South Africa, HIV-1, HIV Infections, Incidence, Herpesvirus 2, Human, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review