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Cited by 104Influenza Virus Research StudiesRespiratory viral infections researchCOVID-19 Clinical Research Studies

Diagnostic importance of relative lymphopenia as a marker of swine influenza (H1N1) in adults.

Cunha, Burke A., Pherez, Francisco M., Schoch, Paul·2009·Clinical Infectious Diseases
DOI 10.1086/644496
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Abstract

To the Editor—Unlike severe influenza A, which has characteristic findings, mild or moderate influenza A is clinically indistinguishable from influenza-like illness [1, 2]. Early in the swine influenza (H1N1) pandemic (April and May 2009), our emergency department was inundated with 856 patient requests for rapid influenza A testing and/or evaluation. The H1N1 pandemic began at the end of the annual human influenza A season, and other respiratory viruses that cause influenza-like illness were present in the community as well. Although the rapid flu test (Quick-S Influ A/B kit; Denka Seiken) has ∼20% false negative results for influenza A, it is used in our emergency department because it is rapid and inexpensive [3, 4]. In April and May, because the local health department was overwhelmed with requests for H1N1 testing, reverse transcription polymerase chain reaction (RT-PCR) testing was performed if the rapid influenza A test was positive and/or the patient reported recent travel to Mexico or close contact with New York City epicenter cases.

Integrity signals

Registry

Crossref · 10.1086/644496

Cites

7 of 7 references verified0 citation errors · 0 not checkable

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  • de Jong et al. (2006) found that influenza infection caused lower levels of cytotoxic T cell lymphocytes, which would negatively affect acquired immunity.

    “de Jong et al. (2006) found influenza infection caused lower levels of cytotoxic T cell lymphocytes, which would therefore negatively affect acquired immunity (de Jong et al., 2006; Cunha et al., 2009).”

    From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Cunha et al., 2009

  • Infection with some influenza subtypes, such as H1N1 and H5N1, typically results in lymphopenia, which has been associated with higher viral load.

    “Furthermore infection with some influenza subtypes, for instance H1N1 and H5N1, typically result in lymphopenia, a state of abnormally low levels of lymphocytes, which has been associated with higher viral load.”

    From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Cunha et al., 2009

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Related

Authors
Cunha, B. A., Pherez, F. M., & Schoch, P.
Affiliations
  • Stony Brook University (US)
  • Winthrop-University Hospital (US)
Corresponding author
Cunha, Burke A.
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2009-11
Volume
49
Issue
9
Pages
1454-1456
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/644496
OpenAlex
W1988440713
Cited by
104
References
7
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 1 · 2021: 10 · 2020: 8 · 2019: 6 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 14
FWCI
11.19
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
swine influenza A (H1N1), 2009 H1N1 pandemic, lymphocyte count, diagnostic biomarkers, influenza-like illness, false-negative results, RT-PCR, emergency department, adults
MeSH terms
Adolescent, Adult, Child, Child, Preschool, Humans, Influenza, Human, Lymphopenia, Middle Aged, Influenza A Virus, H1N1 Subtype, Young Adult

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