Staphylococcus aureus Panton‐Valentine Leukocidin Targets Muscle Tissues in a Child with Myositis and Necrotizing Fasciitis
Abstract
The incidence of myositis has been increasing since the advent of the epidemic of community-associated methicillin-resistant Staphylococcus aureus infection, and Panton-Valentine leukocidin has been implicated as a factor contributing to more-severe muscle injury. We report a case of severe myositis accompanying septic osteomyelitis and necrotizing fasciitis caused by a Panton-Valentine leukocidin-positive S. aureus strain. Immunostaining showed strong binding of the Panton-Valentine leukocidin toxin to necrotic muscle tissues.
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Miller, L. G., Perdreau-Remington, F., Rieg, G., Mehdi, S., Perlroth, J., Bayer, A. S., Tang, A. W., Phung, T. O., & Spellberg, B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042683 · Cited by 1,053 · see citing works
Self-citationBacterial Competition for Human Nasal Cavity Colonization: Role of Staphylococcal <i>agr</i> Alleles
Lina, G., Boutite, F., Tristan, A., Bes, M., Etienne, J., & Vandenesch, F. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.1.18-23.2003 · Cited by 381 · see citing works
Charlebois, E. D., Bangsberg, D. R., Moss, N. J., Moore, M. R., Moss, A. R., Chambers, H. F., & Perdreau-Remington, F. (2002) · Clinical Infectious Diseases · doi:10.1086/338069 · Cited by 245 · see citing works
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Otto, M. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134309 · Cited by 457 · see citing works
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- Authors
- Lehman, D., Tseng, C. W., Eells, S., Miller, L. G., Fan, X., Beenhouwer, D. O., & Liu, G. Y.
- Affiliations
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-01
- Volume
- 50
- Issue
- 1
- Pages
- 69-72
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2133639626
- Cited by
- 15
- References
- 3
- Citations by year
- 2024: 1 · 2023: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agência Regional para o Desenvolvimento da Investigação, Tecnologia e Inovação
- National Institute of Allergy and Infectious Diseases (R01AI074832, AI074832)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Infectious Diseases › Otolaryngology and Infectious Diseases
- Keywords
- Panton-Valentine leukocidin, Staphylococcus aureus, myositis, necrotizing fasciitis, septic osteomyelitis, community-associated methicillin-resistant Staphylococcus aureus, pediatric infection
- MeSH terms
- Bacterial Toxins, Child, Exotoxins, Histocytochemistry, Humans, Leukocidins, Male, Myositis, Radiography, Shoulder, Staphylococcus aureus, Polymerase Chain Reaction, Fasciitis, Necrotizing
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