Basis of Virulence in Community-Associated Methicillin-Resistant Staphylococcus aureus
Abstract
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains are causing a severe pandemic of mainly skin and soft tissue and occasionally fatal infections. The basis of their success is the combination of methicillin resistance at low fitness cost and high virulence. Investigation of the virulence potential of CA-MRSA, a key prerequisite for the development of anti-CA-MRSA therapeutics, has focused on strain USA300, which is responsible for the most serious CA-MRSA epidemic seen in the United States. Current data indicate that in this strain virulence evolved via increased expression of core-genome-encoded virulence determinants, such as alpha-toxin and phenol-soluble modulins, and acquisition of the phage-encoded Panton-Valentine leukocidin (PVL) genes. All these toxins impact disease progression in animal models of USA300 infection. In contrast, the basis of virulence in other CA-MRSA epidemics, which also include PVL-negative strains, is poorly understood.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These virulence factors include Panton-Valentine leukocidin (pvl), staphylococcal protein A (spa) and α-hemolysin (hla).
“These virulence factors include Panton-Valentine leukocidin (pvl), staphylococcal protein A (spa) and α-hemolysin (hla) [24].”
From Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection (2013) · cites this paper as [24]
Cites
The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678 · see citing works
Staphylococcus aureus Infections
Lowy, F. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199808203390806 · Cited by 6,018 · see citing works
Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · see citing works
The role of nasal carriage in Staphylococcus aureus infections
Wertheim, H. F., Melles, D. C., Vos, M. C., van Leeuwen, W., van Belkum, A., Verbrugh, H. A., & Nouwen, J. L. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70295-4 · Cited by 2,685 · see citing works
Lina, G., Piemont, Y., Godail-Gamot, F., Bes, M., Peter, M.-O., Gauduchon, V., Vandenesch, F., & Etienne, J. (1999) · Clinical Infectious Diseases · doi:10.1086/313461 · Cited by 2,489 · see citing works
Methicillin-Resistant <i>S. aureus</i> Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285 · see citing works
Nasal Carriage as a Source of<i>Staphylococcus aureus</i>Bacteremia
von Eiff, C., Becker, K., Machka, K., Stammer, H., & Peters, G. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440102 · Cited by 1,984 · see citing works
Staphylococcus epidermidis — the 'accidental' pathogen
Otto, M. J. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2182 · Cited by 1,828 · see citing works
Self-citationVandenesch, F., Naimi, T. S., Enright, M. C., Lina, G., Nimmo, G. R., Heffernan, H., Liassine, N., Bes, M., Greenland, T., Reverdy, M. E., et al. (2003) · Emerging infectious diseases · doi:10.3201/eid0908.030089 · Cited by 1,718 · see citing works
Diep, B. A., Gill, S. R., Chang, R. F., Phan, T. H., Chen, J. H., Davidson, M. G., Lin, F., Lin, J., Carleton, H. A., Mongodin, E. F., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68231-7 · Cited by 1,633 · see citing works
The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
Enright, M. C., Robinson, D. A., Randle, G. A., Feil, E. J., Grundmann, H., & Spratt, B. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122108599 · Cited by 1,591 · see citing works
Gillet, Y., Issartel, B., Vanhems, P., Fournet, J.-C., Lina, G., Bes, M., Vandenesch, F., Piémont, Y., Brousse, N., Floret, D., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07877-7 · Cited by 1,514 · see citing works
Methicillin-Resistant <i>Staphylococcus aureus</i> Disease in Three Communities
Fridkin, S. K., Hageman, J. C., Morrison, M., Sanza, L. T., Como-Sabetti, K., Jernigan, J. A., Harriman, K., Harrison, L. H., Lynfield, R., & Farley, M. M. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043252 · Cited by 1,493 · see citing works
Antimicrobial resistance: the example of Staphylococcus aureus
Lowy, F. D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18535 · Cited by 1,446 · see citing works
Herold, B. C. (1998) · JAMA · doi:10.1001/jama.279.8.593 · Cited by 1,412 · see citing works
Genome and virulence determinants of high virulence community-acquired MRSA
Baba, T., Takeuchi, F., Kuroda, M., Yuzawa, H., Aoki, K.-I., Oguchi, A., Nagai, Y., Iwama, N., Asano, K., Naimi, T. S., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08713-5 · Cited by 1,356 · see citing works
Immune evasion by staphylococci
Foster, T. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1289 · Cited by 1,214 · see citing works
Miller, L. G., Perdreau-Remington, F., Rieg, G., Mehdi, S., Perlroth, J., Bayer, A. S., Tang, A. W., Phung, T. O., & Spellberg, B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042683 · Cited by 1,053 · see citing works
Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., Kennedy, A. D., Dorward, D. W., Klebanoff, S. J., Peschel, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1656 · Cited by 1,046 · see citing works
Self-citationSurface protein adhesins of Staphylococcus aureus
Foster, T. J., & Höök, M. (1998) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01400-0 · Cited by 985 · see citing works
Gorwitz, R. J., Kruszon‐Moran, D., McAllister, S. K., McQuillan, G. M., McDougal, L. K., Fosheim, G. E., Jensen, B. J., Killgore, G., Tenover, F. C., & Kuehnert, M. J. (2008) · The Journal of Infectious Diseases · doi:10.1086/533494 · Cited by 930 · see citing works
Klein, E. Y., Smith, D. L., & Laxminarayan, R. (2007) · Emerging infectious diseases · doi:10.3201/eid1312.070629 · Cited by 859 · see citing works
Alpha-toxin of Staphylococcus aureus
Bhakdi, S. C., & Tranum-Jensen, J. (1991) · Microbiological Reviews · doi:10.1128/mr.55.4.733-751.1991 · Cited by 782 · see citing works
A Clone of Methicillin-Resistant Staphylococcus aureus among Professional Football Players
Kazakova, S. V., Hageman, J. C., Matava, M. J., Srinivasan, A., Phelan, L. P., Garfinkel, B. T., Boo, T., McAllister, S. K., Anderson, J., Jensen, B. J., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042859 · Cited by 736 · see citing works
Methicillin-resistant staphylococci
Barber, M. (1961) · Journal of Clinical Pathology · doi:10.1136/jcp.14.4.385 · Cited by 732 · see citing works
Francis, J. S., Doherty, M. C., Lopatin, U. A., Johnston, C. P., Sinha, G., Ross, T. L., Cai, M., Hansel, N. N., Perl, T. M., Ticehurst, J. R., et al. (2004) · Clinical Infectious Diseases · doi:10.1086/427148 · Cited by 715 · see citing works
Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia
Labandeira‐Rey, M., Couzon, F., Boisset, S., Brown, E. L., Bes, M., Benito, Y., Barbu, E. M., Sarathy, V. V., Höök, M., Étienne, J., et al. (2007) · Science · doi:10.1126/science.1137165 · Cited by 707 · see citing works
Seybold, U., Kourbatova, E. V., Johnson, J. G., Halvosa, S. J., Wang, Y. F., King, M. D., Ray, S. M., & Blumberg, H. M. (2006) · Clinical Infectious Diseases · doi:10.1086/499815 · Cited by 687 · see citing works
Three-Year Surveillance of Community-AcquiredStaphylococcus aureus Infections in Children
Kaplan, S. L., Hultén, K. G., Gonzalez, B. E., Hammerman, W. A., Lamberth, L. B., Versalovic, J. A., & Mason, E. O. (2005) · Clinical Infectious Diseases · doi:10.1086/430312 · Cited by 597 · see citing works
Queck, S. Y., Jameson‐Lee, M., Villaruz, A. E., Bach, T. L., Khan, B. A., Sturdevant, D. E., Ricklefs, S., Li, M., & Otto, M. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.08.005 · Cited by 596 · see citing works
Self-citationVoyich, J. M., Braughton, K. R., Sturdevant, D. E., Whitney, A. R., Saïd-Salim, B., Porcella, S. F., Long, R. D., Dorward, D. W., Gardner, D. J., Kreiswirth, B. N., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.6.3907 · Cited by 563 · see citing works
Voyich, J. M., Otto, M. J., Mathema, B., Braughton, K. R., Whitney, A. R., Welty, D. M., Long, R. D., Dorward, D. W., Gardner, D. J., Lina, G., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/509506 · Cited by 562 · see citing works
Self-citationMethicillin-Resistant Staphylococcus aureus at Boston City Hospital
Barrett, F. F., McGehee, R. F., & Finland, M. (1968) · New England Journal of Medicine · doi:10.1056/nejm196808292790901 · Cited by 519 · see citing works
Extraction of a Highly Potent Penicillin Inactivator from Penicillin Resistant Staphylococci
Kirby, W. (1944) · Science · doi:10.1126/science.99.2579.452 · Cited by 502 · see citing works
Poring over pores: α-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia
Bubeck Wardenburg, J., Bae, T., Otto, M., DeLeo, F. R., & Schneewind, O. (2007) · Nature Medicine · doi:10.1038/nm1207-1405 · Cited by 492 · see citing works
Self-citationLöffler, B., Hussain, M. S., Grundmeier, M., Brück, M., Holzinger, D., Varga, G., Roth, J., Kahl, B. C., Proctor, R. A., & Peters, G. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000715 · Cited by 440 · see citing works
Diep, B. A., Stone, G. G., Basuino, L., Graber, C. J., Miller, A. A., Etages, S. A. D., Jones, A., Palazzolo‐Ballance, A. M., Perdreau‐Remington, F., Sensabaugh, G. F., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/587907 · Cited by 421 · see citing works
Genestier, A.-L., Michallet, M.-C., Prévost, G., Bellot, G., Chalabreysse, L., Peyrol, S., Thivolet, F., Etienne, J., Lina, G., Vallette, F. M., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22684 · Cited by 416 · see citing works
Vaccine protection against Staphylococcus aureus pneumonia
Wardenburg, J. B., & Schneewind, O. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072208 · Cited by 406 · see citing works
Li, M., Diep, B. A., Villaruz, A. E., Braughton, K. R., Jiang, X., DeLeo, F. R., Chambers, H. F., Lu, Y., & Otto, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900743106 · Cited by 394 · see citing works
Self-citationDiep, B. A., Chambers, H. F. “., Graber, C. J., Szumowski, J. D., Miller, L. G., Han, L. L., Chen, J. H., Lin, F., Lin, J., Phan, T. H., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-4-200802190-00204 · Cited by 390 · see citing works
Kennedy, A. D., Otto, M. J., Braughton, K. R., Whitney, A. R., Chen, L., Mathema, B., Mediavilla, J. R., Byrne, K. A., Parkins, L. D., Tenover, F. C., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710217105 · Cited by 387 · see citing works
Self-citationPopovich, K. J., Weinstein, R. A., & Hota, B. N. (2008) · Clinical Infectious Diseases · doi:10.1086/528716 · Cited by 375 · see citing works
INFECTION BY PENICILLIN-RESISTANT STAPHYLOCOCCI
Barber, M., & Rozwadowska-Dowzenko, M. (1948) · The Lancet · doi:10.1016/s0140-6736(48)92166-7 · Cited by 368 · see citing works
Udo, E. E. (1993) · Journal of Hospital Infection · doi:10.1016/0195-6701(93)90100-e · Cited by 358 · see citing works
Mechanisms of Antibiotic Resistance in Staphylococcus Aureus
Pantosti, A., Sanchini, A., & Monaco, M. (2007) · Future Microbiology · doi:10.2217/17460913.2.3.323 · Cited by 348 · see citing works
Diep, B. A., Chan, L., Tattevin, P., Kajikawa, O., Martin, T. R., Basuino, L., Mai, T. T., Marbach, H., Braughton, K. R., Whitney, A. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912403107 · Cited by 347 · see citing works
Kaneko, J., & Kamio, Y. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.981 · Cited by 334 · see citing works
The role of virulence determinants in community-associated MRSA pathogenesis
Diep, B. A., & Otto, M. J. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2008.05.002 · Cited by 329 · see citing works
Self-citationMETHICILLIN RESISTANCE IN STAPHYLOCOCCI
Jevons, M. P. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91687-8 · Cited by 322 · see citing works
Daum, R. S., Ito, T., Hiramatsu, K., Hussain, F., Mongkolrattanothai, K., Jamklang, M., & Boyle‐Vavra, S. (2002) · The Journal of Infectious Diseases · doi:10.1086/344326 · Cited by 295 · see citing works
Human Formyl Peptide Receptor 2 Senses Highly Pathogenic Staphylococcus aureus
Kretschmer, D., Gleske, A.-K., Rautenberg, M., Wang, R., Köberle, M., Bohn, E., Schöneberg, T., Rabiet, M., Boulay, F., Klebanoff, S. J., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.05.012 · Cited by 287 · see citing works
Self-citationStaphylococcus aureusSepsis and the Waterhouse–Friderichsen Syndrome in Children
Adem, P. V., Montgomery, C. P., Husain, A. N., Koogler, T. K., Arangelovich, V., Humilier, M., Boyle‐Vavra, S., & Daum, R. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044194 · Cited by 277 · see citing works
Staphylococcal innate immune evasion
Rooijakkers, S. H. M., van Kessel, K. P. M., & van Strijp, J. A. G. (2005) · Trends in Microbiology · doi:10.1016/j.tim.2005.10.002 · Cited by 267 · see citing works
Panton, P. N., & Valentine, F. C. O. (1932) · The Lancet · doi:10.1016/s0140-6736(01)24468-7 · Cited by 249 · see citing works
Wardenburg, J. B., Palazzolo‐Ballance, A. M., Otto, M., Schneewind, O., & DeLeo, F. R. (2008) · The Journal of Infectious Diseases · doi:10.1086/592053 · Cited by 236 · see citing works
Self-citationKaneko, J., Kimura, T., Narita, S., Tomita, N., & Kamio, Y. (1998) · Gene · doi:10.1016/s0378-1119(98)00278-9 · Cited by 231 · see citing works
Mobile Genetic Element-Encoded Cytolysin Connects Virulence to Methicillin Resistance in MRSA
Queck, S. Y., Khan, B. A., Wang, R., Bach, T. L., Kretschmer, D., Chen, L., Kreiswirth, B. N., Peschel, A., DeLeo, F. R., & Otto, M. J. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000533 · Cited by 227 · see citing works
Self-citationCommunity Strain of Methicillin-Resistant Staphylococcus aureus Involved in a Hospital Outbreak
O’Brien, F. G., Pearman, J. W., Gracey, M. S., Riley, T. V., & Grubb, W. B. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.9.2858-2862.1999 · Cited by 213 · see citing works
An Inflammatory Polypeptide Complex from Staphylococcus epidermidis: Isolation and Characterization
Mehlin, C., Headley, C. M., & Klebanoff, S. J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.6.907 · Cited by 210 · see citing works
Montgomery, C. P., Boyle‐Vavra, S., Adem, P. V., Lee, J. C., Husain, A. N., Clasen, J., & Daum, R. S. (2008) · The Journal of Infectious Diseases · doi:10.1086/590157 · Cited by 208 · see citing works
Liu, C., Graber, C. J., Karr, M., Diep, B. A., Basuino, L., Schwartz, B. S., Enright, M. C., O’Hanlon, S. J., Thomas, J. C., Perdreau‐Remington, F., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/587893 · Cited by 205 · see citing works
Wisplinghoff, H., Rosato, A. E., Enright, M. C., Noto, M. J., Craig, W. A., & Archer, G. L. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.11.3574-3579.2003 · Cited by 203 · see citing works
Ragle, B. E., & Bubeck Wardenburg, J. (2009) · Infection and Immunity · doi:10.1128/iai.00115-09 · Cited by 202 · see citing works
Noskin, G. A., Rubin, R. J., Schentag, J. J., Kluytmans, J. A. J. W., Hedblom, E. C., Jacobson, C., Smulders, M., Gemmen, E., & Bharmal, M. F. (2007) · Clinical Infectious Diseases · doi:10.1086/522186 · Cited by 201 · see citing works
Diep, B. A., Palazzolo‐Ballance, A. M., Tattevin, P., Basuino, L., Braughton, K. R., Whitney, A. R., Chen, L., Kreiswirth, B. N., Otto, M. J., DeLeo, F. R., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003198 · Cited by 188 · see citing works
Self-citationGilbert, M. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.051565 · Cited by 187 · see citing works
Epidemic of Community-Acquired Methicillin-Resistant Staphylococcus aureus Infections
Purcell, K., & FERGIE, J. E. (2005) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.159.10.980 · Cited by 172 · see citing works
Ghebremedhin, B., Olugbosi, M. O., Raji, A. M., Layer, F., Bakare, R. A., König, B., & König, W. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.00648-09 · Cited by 165 · see citing works
Rossney, A. S., Shore, A. C., Morgan, P. M., Fitzgibbon, M. M., O'Connell, B. C., & Coleman, D. C. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.00245-07 · Cited by 164 · see citing works
Gorwitz, R. J. (2008) · Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e31815819bb · Cited by 164 · see citing works
König, B., Prévost, G., Piémont, Y., & König, W. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.3.607 · Cited by 164 · see citing works
Brown, E. L., Dumitrescu, O., Thomas, D. Y., Badiou, C., Koers, E. M., Choudhury, P., Vazquez, V., Étienne, J., Lina, G., Vandenesch, F., et al. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.02648.x · Cited by 162 · see citing works
Coombs, G. W., Nimmo, G. R., Bell, J. M., Huygens, F., O’Brien, F. G., Malkowski, M. J., Pearson, J. C., Stephens, A. J., & Giffard, P. M. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.10.4735-4743.2004 · Cited by 161 · see citing works
Staphylococcus aureus Leukocidin: A New Virulence Factor in Cutaneous Infections?
Cribier, B. J., Prévost, G., Couppié, P., Finck‐Barbançon, V., Grosshans, E., & Piémont, Y. (2009) · Dermatology · doi:10.1159/000247443 · Cited by 159 · see citing works
Apolipoprotein B Is an Innate Barrier against Invasive Staphylococcus aureus Infection
Peterson, M. M., Mack, J. L., Hall, P. R., Alsup, A. A., Alexander, S. M., Sully, E. K., Sawires, Y. S., Cheung, A. L., Otto, M. J., & Gresham, H. D. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.10.001 · Cited by 157 · see citing works
Self-citationPathogenicity and resistance islands of staphylococci
Novick, R. P., Schlievert, P. M., & Ruzin, A. V. (2001) · Microbes and Infection · doi:10.1016/s1286-4579(01)01414-9 · Cited by 157 · see citing works
Bacterial virulence as a target for antimicrobial chemotherapy
Alksne, L. E., & Projan, S. J. (2000) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(00)00155-5 · Cited by 156 · see citing works
Campbell, K. M. D. L., Vaughn, A. F., Russell, K. L., Smith, B., Jimenez, D. L., Barrozo, C. P., Minarcik, J. R., Crum, N. F., & Ryan, M. A. K. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.9.4050-4053.2004 · Cited by 153 · see citing works
Reyes, J., Rincón, S., Díaz, L., Panesso, D., Contreras, G., Zurita, J., Carrillo, C., Rizzi, A., Guzmán, M., Adachi, J. A., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/648426 · Cited by 151 · see citing works
A survey of community-associated methicillin-resistant Staphylococcus aureus in Korea
Kim, E. S., Song, J. S., Lee, H., Choe, P. G., Park, K. H., Cho, J. H., Park, W. B., Kim, S., Bang, J.-H., Kim, D., et al. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm309 · Cited by 149 · see citing works
Community-associated Methicillin-resistantStaphylococcus aureus, Canada
Mulvey, M. R., MacDougall, L., Cholin, B., Horsman, G. B., Fidyk, M., Woods, S., & the Saskatchewan CA-MRSA Study Group (2005) · Emerging infectious diseases · doi:10.3201/eid1106.041146 · Cited by 133 · see citing works
Diversity among Community Isolates of Methicillin-Resistant Staphylococcus aureus in Australia
O’Brien, F. G., Lim, T. T., Chong, F. N., Coombs, G. W., Enright, M. C., Robinson, D. A., Monk, A. B., Saïd-Salim, B., Kreiswirth, B. N., & Grubb, W. B. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.7.3185-3190.2004 · Cited by 133 · see citing works
Crémieux, A., Dumitrescu, O., Lina, G., Vallée, C. A., Côté, J.-F., Muffat‐Joly, M., Lilin, T., Étienne, J., Vandenesch, F., & Saleh‐Mghir, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007204 · Cited by 127 · see citing works
Lee, S. M., Ender, M., Adhikari, R. P., Smith, J. M. B., Berger‐Bächi, B., & Cook, G. M. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01239-06 · Cited by 119 · see citing works
Transmembrane β-barrel of staphylococcal α-toxin forms in sensitive but not in resistant cells
Valeva, A., Walev, I., Pinkernell, M., Walker, B. W., Bayley, H., Palmer, M., & Bhakdi, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11607 · Cited by 113 · see citing works
Monecke, S., Slickers, P., Ellington, M. J., Kearns, A., & Ehricht, R. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01833.x · Cited by 112 · see citing works
Witte, W., Strommenger, B., Cuny, C., Heuck, D., & Nuebel, U. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm384 · Cited by 109 · see citing works
Properties of ion channels formed by Staphylococcus aureus δ-toxin
Mellor, I. R., Thomas, D. H., & Sansom, M. S. P. (1988) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(88)90030-2 · Cited by 102 · see citing works
(2009) · Emerging Infectious Diseases · doi:10.3201/eid1512.081341 · Cited by 102 · see citing works
Tseng, C. W., Kyme, P. A., Low, J., Rocha, M. A., Alsabeh, R., Miller, L. G., Otto, M. J., Arditi, M., Diep, B. A., Nizet, V., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006387 · Cited by 102 · see citing works
Self-citationBartlett, A. H., Foster, T. J., Hayashida, A., & Park, P. W. (2008) · The Journal of Infectious Diseases · doi:10.1086/592758 · Cited by 101 · see citing works
Bae, I., Tonthat, G. T., Stryjewski, M. E., Rude, T. H., Reilly, L. F., Barriere, S. L., Genter, F. C., Corey, G. R., & Fowler, V. G. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.01643-09 · Cited by 99 · see citing works
Staphylococcal Vaccines and Immunotherapies
Schaffer, A. C., & Lee, J. C. (2009) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2008.10.005 · Cited by 97 · see citing works
Studies on the binding of staphylococcal 125I-labeled α-toxin to rabbit erythrocytes
Cassidy, P. S., & Harshman, S. (1976) · Biochemistry · doi:10.1021/bi00656a016 · Cited by 96 · see citing works
Donvito, B., Étienne, J., Denoroy, L., Greenland, T., Benito, Y., & Vandenesch, F. (1997) · Infection and Immunity · doi:10.1128/iai.65.1.95-100.1997 · Cited by 91 · see citing works
Offsetting virulence and antibiotic resistance costs by MRSA
Collins, J., Rudkin, J., Recker, M., Pozzi, C., O’Gara, J. P., & Massey, R. C. (2010) · The ISME Journal · doi:10.1038/ismej.2009.151 · Cited by 89 · see citing works
Sax, H., Posfay-Barbe, K. M., Harbarth, S., François, P., Touveneau, S., Pessoa-Silva, C. L., Schrenzel, J., Dharan, S., Gervaix, A., & Pittet, D. (2006) · Journal of Hospital Infection · doi:10.1016/j.jhin.2005.11.016 · Cited by 89 · see citing works
Otter, J. A., & French, G. L. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.02017.x · Cited by 87 · see citing works
Ho, P., Chuang, S. K., Choi, Y.-F., Lee, R. A., Lit, A. C., Ng, T. K., Que, T., Shek, K.-C., Tong, H.-K., Tse, C. W. S., et al. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2007.12.015 · Cited by 87 · see citing works
Leukocidal Toxins of Staphylococci
Szmigielski, S., Prévost, G., Monteil, H., Colin, D. A., & Jeljaszewicz, J. (1999) · Zentralblatt für Bakteriologie · doi:10.1016/s0934-8840(99)80105-4 · Cited by 85 · see citing works
Huang, Y., Ho, C., Chen, C. J., Su, L.-H., & Lin, T. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.02115.x · Cited by 85 · see citing works
Villaruz, A. E., Wardenburg, J. B., Khan, B. A., Whitney, A. R., Sturdevant, D. E., Gardner, D. J., DeLeo, F. R., & Otto, M. J. (2009) · The Journal of Infectious Diseases · doi:10.1086/604728 · Cited by 84 · see citing works
Self-citationHongo, I., Baba, T., Oishi, K., Morimoto, Y., Ito, T., & Hiramatsu, K. (2009) · The Journal of Infectious Diseases · doi:10.1086/605332 · Cited by 80 · see citing works
Badiou, C., Dumitrescu, O., George, N., Forbes, A., Δρούγκα, Ε., Chan, K. S., Ramdani‐Bouguessa, N., Meugnier, H., Bes, M., Vandenesch, F., et al. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.02274-09 · Cited by 78 · see citing works
Montgomery, C. P., Boyle‐Vavra, S., & Daum, R. S. (2009) · Infection and Immunity · doi:10.1128/iai.00256-09 · Cited by 74 · see citing works
Hsu, L. Y., Koh, Y.-L., Chlebicka, N. L., Tan, T. Y., Krishnan, P., Lin, R. T., Tee, N. W. S., Barkham, T., & Koh, T. H. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.44.3.1090-1093.2006 · Cited by 72 · see citing works
Shibuya, Y., Hara, M., Higuchi, W., Takano, T., Iwao, Y., & Yamamoto, T. (2008) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-008-0640-1 · Cited by 71 · see citing works
Production of the Bsa Lantibiotic by Community-Acquired Staphylococcus aureus Strains
Daly, K. M., Upton, M., Sandiford, S. K., Draper, L. A., Wescombe, P. A., Jack, R. W., O’Connor, P. M., Rossney, A. S., Götz, F., Hill, C., et al. (2009) · Journal of Bacteriology · doi:10.1128/jb.01375-09 · Cited by 69 · see citing works
Montgomery, C. P., & Daum, R. S. (2009) · Infection and Immunity · doi:10.1128/iai.00021-09 · Cited by 67 · see citing works
Emergence of USA300 MRSA in a tertiary medical centre: implications for epidemiological studies
Patel, M., Waites, K. B., Hoesley, C. J., Stamm, A. M., Canupp, K. C., & Moser, S. A. (2008) · Journal of Hospital Infection · doi:10.1016/j.jhin.2007.12.010 · Cited by 64 · see citing works
Prevalence of MRSA strains among Staphylococcus aureus isolated from outpatients, 2006.
Coombs, G. W., Nimmo, G. R., Pearson, J. C., Christiansen, K., Bell, J. M., Collignon, P., & McLaws, M. (2009) · PubMed · doi:10.33321/cdi.2009.33.2 · Cited by 64 · see citing works
Liang, X., & Ji, Y. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00740.x · Cited by 58 · see citing works
Panton–Valentine leukocidin is expressed at toxic levels in human skin abscesses
Badiou, C., Dumitrescu, O., Croze, M., Gillet, Y., Dohin, B., Hayi-Slayman, D., Allaouchiche, B., Étienne, J., Vandenesch, F., & Lina, G. (2008) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.02105.x · Cited by 55 · see citing works
Targeted Immunotherapy for Staphylococcal Infections
Otto, M. J. (2008) · BioDrugs · doi:10.2165/00063030-200822010-00003 · Cited by 54 · see citing works
Self-citationThuong, T. C., Tho, N. D., Hoa, N. T., Phương, N. T. M., Tuấn, L. V., Diep, T. S., Lindsay, J. A., Dung, N. T., Cam, B. V., Thinh, L. Q., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000822 · Cited by 50 · see citing works
Ellis, M. W., Griffith, M. E., Jorgensen, J. H., Hospenthal, D. R., Mende, K., & PATTERSON, J. E. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.02352-08 · Cited by 50 · see citing works
Krüll, M., Dold, C., Hippenstiel, S., Rosseau, S., Lohmeyer, J., & Suttorp, N. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.9.4133 · Cited by 49 · see citing works
Chheng, K., Tarquinio, S., Wuthiekanun, V., Sin, L., Thaipadungpanit, J., Amornchai, P., Chanpheaktra, N., Tumapa, S., Putchhat, H., Day, N., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006630 · Cited by 48 · see citing works
Olsen, R. J., Kobayashi, S. D., Ayeras, A. A., Ashraf, M., Graves, S. F., Ragasa, W., Humbird, T. L., Greaver, J. L., Cantu, C., Swain, J. L., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090960 · Cited by 48 · see citing works
Baranovich, T., Zaraket, H., Shabana, I., Афанасьевна, Н. В., Turcutyuicov, V. B., & Suzuki, H. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.02891.x · Cited by 47 · see citing works
An antidote forStaphylococcus aureuspneumonia?
DeLeo, F. R., & Otto, M. J. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080167 · Cited by 46 · see citing works
Self-citationMolecular Epidemiology of Methicillin-ResistantStaphylococcus aureus, Rural Southwestern Alaska1
David, M. Z., Rudolph, K. M., Hennessy, T. W., Boyle‐Vavra, S., & Daum, R. S. (2008) · Emerging infectious diseases · doi:10.3201/eid1411.080381 · Cited by 42 · see citing works
Graves, S. F., Kobayashi, S. D., Braughton, K. R., Diep, B. A., Chambers, H. F. “., Otto, M. J., & DeLeo, F. R. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.02.005 · Cited by 42 · see citing works
Self-citationThe amino acid sequence of a gonococcal growth inhibitor from Staphylococcus haemolyticus
Watson, D. C., Yaguchi, M., Bisaillon, J.-G., Beaudet, R., & Morosoli, R. (1988) · Biochemical Journal · doi:10.1042/bj2520087 · Cited by 41 · see citing works
Tristan, A., Benito, Y., Montserret, R., Boisset, S., Dusserre, E., Pénin, F., Ruggiero, F., Étienne, J., Lortat‐Jacob, H., Lina, G., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005042 · Cited by 36 · see citing works
Coronado, F., Nicholas, J. A., Wallace, B. J., Kohlerschmidt, D. J., Musser, K. A., Schoonmaker-Bopp, D. J., ZIMMERMAN, S. M., BOLLER, A. R., Jernigan, D. B., & Kacica, M. A. (2006) · Epidemiology and Infection · doi:10.1017/s0950268806006960 · Cited by 33 · see citing works
Lee, S. S., Kim, Y.-J., Chung, D. R., Jung, K., & Kim, J. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.00297-09 · Cited by 33 · see citing works
Szmigielski, S., Sobiczewska, E., Prévost, G., Monteil, H., Colin, D. A., & Jeljaszewicz, J. (1998) · Zentralblatt für Bakteriologie · doi:10.1016/s0934-8840(98)80012-1 · Cited by 30 · see citing works
Adam, H. J., Allen, V. G., Currie, A., McGeer, A., Simor, A. E., Richardson, S. E., Louie, L., Willey, B. M., Rutledge, T., Lee, J. S., et al. (2009) · Canadian Journal of Emergency Medicine · doi:10.1017/s1481803500011635 · Cited by 30 · see citing works
Chini, V., Petinaki, E., Meugnier, H., Foka, A., Bes, M., Étienne, J., Dimitracopoulos, G., & Spiliopoulou, I. T. (2008) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540701749230 · Cited by 25 · see citing works
Treatment of Infections Caused by Resistant Staphylococcus aureus
Anstead, G. M., Quinones-Nazario, G., & Lewis, J. S. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-468-1_17 · Cited by 21 · see citing works
Barr, B. A. T., Felkner, M. M., & Diamond, P. M. (2006) · PubMed · Cited by 18 · see citing works
Lehman, D., Tseng, C. W., Eells, S., Miller, L. G., Fan, X., Beenhouwer, D. O., & Liu, G. Y. (2010) · Clinical Infectious Diseases · doi:10.1086/649217 · Cited by 15 · see citing works
Ogston's Coccus: 102 years and still going strong.
Smith, G. (1982) · PubMed · Cited by 10 · see citing works
SMITH, G. (1982) · Southern Medical Journal · doi:10.1097/00007611-198212000-00026 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,697 · see citing works
Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3161 · Cited by 1,534 · see citing works
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. J. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,456 · see citing works
Self-citationDifferent drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance
Dickey, S. W., Cheung, G. Y. C., & Otto, M. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.23 · Cited by 804 · see citing works
Self-citationSkin microbiota–host interactions
Chen, Y. E., Fischbach, M. A., & Belkaid, Y. (2018) · Nature · doi:10.1038/nature25177 · Cited by 788 · see citing works
Otto, M. J. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.11.004 · Cited by 652 · see citing works
Self-citationOtto, M. J. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-042711-140023 · Cited by 606 · see citing works
Self-citationStaphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases
de Oliveira, D. M., Borges, A. D. S., & Simões, M. V. (2018) · Toxins · doi:10.3390/toxins10060252 · Cited by 493 · see citing works
Phenol-soluble modulins and staphylococcal infection
Peschel, A., & Otto, M. J. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3110 · Cited by 455 · see citing works
Self-citationAlgammal, A. M., Hetta, . F., Elkelish, A., Alkhalifah, D. H. H., Hozzein, W. N., Batiha, G. E., Nahhas, N. E., & Mabrok, M. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s272733 · Cited by 443 · see citing works
Immunity against Staphylococcus aureus cutaneous infections
Miller, L. S., & Cho, J. S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3010 · Cited by 428 · see citing works
Vandenesch, F., Lina, G., & Henry, T. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00012 · Cited by 405 · see citing works
Neutrophils in innate host defense against Staphylococcus aureus infections
Rigby, K. M., & DeLeo, F. R. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0295-3 · Cited by 400 · see citing works
Antibiotic-loaded nanoparticles targeted to the site of infection enhance antibacterial efficacy
Hussain, S., Joo, J., Kang, J., Kim, B., Braun, G. B., She, Z.-G., Kim, D., Mann, A. P., Mölder, T., Teesalu, T., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0187-5 · Cited by 399 · see citing works
Sully, E. K., Małachowa, N., Elmore, B. O., Alexander, S. M., Femling, J., Gray, B. M., DeLeo, F. R., Otto, M. J., Cheung, A. L., Edwards, B. S., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004174 · Cited by 394 · see citing works
Self-citationPastar, I., Nusbaum, A. G., Gil, J., Patel, S. B., Chen, J., Valdes, J., Stojadinovic, O., Plano, L. R., Tomic-Canic, M., & Davis, S. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056846 · Cited by 391 · see citing works
Community-associated MRSA: What makes them special?
Otto, M. (2013) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2013.02.007 · Cited by 379 · see citing works
Self-citationPhenol-soluble modulins – critical determinants of staphylococcal virulence
Cheung, G. Y. C., Joo, H., Chatterjee, S. S., & Otto, M. J. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12057 · Cited by 377 · see citing works
Self-citationSmall Proteins Can No Longer Be Ignored
Storz, G., Wolf, Y. I., & Ramamurthi, K. S. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-070611-102400 · Cited by 359 · see citing works
Otto, M. J. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01832.x · Cited by 338 · see citing works
Self-citationCheung, G. Y. C., Wang, R., Khan, B. A., Sturdevant, D. E., & Otto, M. J. (2011) · Infection and Immunity · doi:10.1128/iai.00046-11 · Cited by 317 · see citing works
Self-citationTargeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy
Kong, C., Neoh, H., & Nathan, S. (2016) · Toxins · doi:10.3390/toxins8030072 · Cited by 317 · see citing works
Neutrophils Versus Staphylococcus aureus : A Biological Tug of War
Spaan, A. N., Surewaard, B. G. J., Nijland, R., & van Strijp, J. A. G. (2013) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092412-155746 · Cited by 305 · see citing works
Staphylococcus aureus Shifts toward Commensalism in Response to Corynebacterium Species
Ramsey, M. M., Freire, M. O., Gabrilska, R. A., Rumbaugh, K. P., & Lemon, K. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01230 · Cited by 299 · see citing works
Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection
Abtin, A., Jain, R., Mitchell, A. J., Roediger, B., Brzoska, A. J., Tikoo, S., Cheng, Q., Ng, L. G., Cavanagh, L. L., von Andrian, U. H., et al. (2013) · Nature Immunology · doi:10.1038/ni.2769 · Cited by 291 · see citing works
Basis of Virulence in Enterotoxin-Mediated Staphylococcal Food Poisoning
Fisher, E. L., Otto, M. J., & Cheung, G. Y. C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00436 · Cited by 289 · see citing works
Self-citationMechanistic Landscape of Membrane-Permeabilizing Peptides
Guha, S., Ghimire, J., Wu, E., & Wimley, W. C. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00520 · Cited by 283 · see citing works
The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus
Alonzo, F., & Torres, V. J. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00055-13 · Cited by 276 · see citing works
Commensal Staphylococci Influence Staphylococcus aureus Skin Colonization and Disease
Parlet, C. P., Severn, M. M., & Horswill, A. R. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.01.008 · Cited by 275 · see citing works
Sutcliffe, J. A., O'Brien, W., Fyfe, C., & Grossman, T. H. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01288-13 · Cited by 235 · see citing works
Staphylococcus aureus toxins – Their functions and genetics
Grumann, D., Nübel, U., & Bröker, B. M. (2013) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2013.03.013 · Cited by 234 · see citing works
Predicting the virulence of MRSA from its genome sequencePreprint
Laabei, M., Recker, M., Rudkin, J., Aldeljawi, M., Gülay, Z., Sloan, T. J., Williams, P. M., Endres, J. L., Bayles, K. W., Fey, P. D., et al. (2014) · Genome Research · doi:10.1101/gr.165415.113 · Cited by 231 · see citing works
Flannagan, R. S., Heit, B., & Heinrichs, D. E. (2015) · Cellular Microbiology · doi:10.1111/cmi.12527 · Cited by 216 · see citing works
What lives on our skin: ecology, genomics and therapeutic opportunities of the skin microbiome
Scharschmidt, T. C., & Fischbach, M. A. (2013) · Drug Discovery Today: Disease Mechanisms · doi:10.1016/j.ddmec.2012.12.003 · Cited by 215 · see citing works
Wilson, G. J., Seo, K. S., Cartwright, R. A., Connelley, T., Chuang-Smith, O. N., Merriman, J. A., Guinane, C. M., Park, J. Y., Bohach, G. A., Schlievert, P. M., et al. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002271 · Cited by 205 · see citing works
Antimicrobial Treatment of Staphylococcus aureus Biofilms
Tuon, F. F., Suss, P. H., Telles, J. P., Dantas, L. R., Borges, N. H., & Ribeiro, V. S. T. (2023) · Antibiotics · doi:10.3390/antibiotics12010087 · Cited by 203 · see citing works
Genetic Tools To Enhance the Study of Gene Function and Regulation in Staphylococcus aureus
Bose, J. L., Fey, P. D., & Bayles, K. W. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.00136-13 · Cited by 195 · see citing works
Geisinger, E., & Isberg, R. R. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw402 · Cited by 195 · see citing works
Staphylococcus aureus: A pathogen with still unresolved issues
Rasigade, J., & Vandenesch, F. (2013) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2013.08.018 · Cited by 194 · see citing works
Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus
Uhlemann, A., Otto, M. J., Lowy, F. D., & DeLeo, F. R. (2013) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2013.04.030 · Cited by 191 · see citing works
Self-citationMiao, J., Pangule, R. C., Paskaleva, E. E., Hwang, E. E., Kane, R. S., Linhardt, R. J., & Dordick, J. S. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.080 · Cited by 185 · see citing works
Antimicrobial resistance in methicillin-resistant staphylococcus aureus
Alghamdi, B. A., Al-Johani, I., Al-Shamrani, J. M., Alshamrani, H. M., Al-Otaibi, B. G., Almazmomi, K., & Yusof, N. Y. (2023) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2023.103604 · Cited by 184 · see citing works
Essential Staphylococcus aureus toxin export system
Chatterjee, S. S., Joo, H., Duong, A. C., Dieringer, T. D., Tan, V. Y., Song, Y. J., Fischer, E. R., Cheung, G. Y. C., Li, M., & Otto, M. J. (2013) · Nature Medicine · doi:10.1038/nm.3047 · Cited by 181 · see citing works
Self-citationReyes-Robles, T., Alonzo, F., Kozhaya, L., Lacy, D. B., Unutmaz, D., & Torres, V. J. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.09.005 · Cited by 179 · see citing works
Otto, M. J. (2013) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2013.11.019 · Cited by 175 · see citing works
Self-citationEvolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus
Laabei, M., Uhlemann, A., Lowy, F. D., Austin, E. D., Yokoyama, M., Ouadi, K., Feil, E. J., Thorpe, H. A., Williams, B. G., Perkins, M., et al. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002229 · Cited by 174 · see citing works
Andersen, J. L., He, G.-X., Kakarla, P., Ranjana, K. C., Kumar, S. H., Lakra, W. S., Mukherjee, M. M., Ranaweera, I., Shrestha, U., Tran, T., et al. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120201487 · Cited by 167 · see citing works
Innate and adaptive immune responses against Staphylococcus aureus skin infections
Krishna, S. M., & Miller, L. S. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0292-6 · Cited by 166 · see citing works
Thurlow, L. R., Joshi, G. S., & Richardson, A. R. (2012) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2012.00937.x · Cited by 163 · see citing works
Rudkin, J., Edwards, A. M., Bowden, M. G., Brown, E. L., Pozzi, C., Waters, E. M., Chan, W. C., Williams, P. M., O’Gara, J. P., & Massey, R. C. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir845 · Cited by 161 · see citing works
Extracellular vesicles: An emerging platform in gram-positive bacteria
Bose, S., Aggarwal, S., Singh, D. V., & Acharya, N. (2020) · Microbial Cell · doi:10.15698/mic2020.12.737 · Cited by 161 · see citing works
Joo, H., Cheung, G. Y. C., & Otto, M. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.221382 · Cited by 155 · see citing works
Self-citationLacey, K. A., Geoghegan, J. A., & McLoughlin, R. M. (2016) · Pathogens · doi:10.3390/pathogens5010022 · Cited by 149 · see citing works
Host–pathogen interactions between the skin and Staphylococcus aureus
Krishna, S. M., & Miller, L. S. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.11.003 · Cited by 148 · see citing works
Genes Contributing to Staphylococcus aureus Fitness in Abscess- and Infection-Related Ecologies
Valentino, M. D., Foulston, L., Sadaka, A., Kos, V. N., Villet, R. A., Maria, J. P. S., Lazinski, D. W., Camilli, A., Walker, S., Hooper, D. C., et al. (2014) · mBio · doi:10.1128/mbio.01729-14 · Cited by 147 · see citing works
Airborne Staphylococcus aureus in different environments—a review
Kozajda, A., Jeżak, K., & Kapsa, A. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06557-1 · Cited by 147 · see citing works
Staphylococcus aureus infections: transmission within households and the community
Knox, J., Uhlemann, A., & Lowy, F. D. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.03.007 · Cited by 146 · see citing works
Discovery of Antivirulence Agents against Methicillin-Resistant Staphylococcus aureus
Khodaverdian, V. Y., Pesho, M. M., Truitt, B. J., Bollinger, L. B., Patel, P., Nithianantham, S., Yu, G.-P., Delaney, E., Jankowsky, E., & Shoham, M. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00269-13 · Cited by 146 · see citing works
Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus
Sakoulas, G., Okumura, C. Y. M., Thienphrapa, W., Olson, J., Nonejuie, P., Dam, Q., Dhand, A., Pogliano, J., Yeaman, M. R., Hensler, M. E., et al. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1100-7 · Cited by 140 · see citing works
Staphylococcus aureus Elaborates Leukocidin AB To Mediate Escape from within Human Neutrophils
Dumont, A., Yoong, P., Surewaard, B. G. J., Benson, M. A., Nijland, R., van Strijp, J. A. G., & Torres, V. J. (2013) · Infection and Immunity · doi:10.1128/iai.00095-13 · Cited by 139 · see citing works
McCourt, J., O’Halloran, D. P., McCarthy, H., O’Gara, J. P., & Geoghegan, J. A. (2014) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12424 · Cited by 137 · see citing works
Gonzalez, D. J., Haste, N. M., Hollands, A., Fleming, T. C., Hamby, M., Pogliano, K., Nizet, V., & Dorrestein, P. C. (2011) · Microbiology · doi:10.1099/mic.0.048736-0 · Cited by 137 · see citing works
Methicillin-resistant Staphylococcus aureus in food and the prevalence in Brazil: a review
Abreu, A. C. D. S., Rodrigues, M. X., & Silva, N. C. C. (2019) · Brazilian Journal of Microbiology · doi:10.1007/s42770-019-00168-1 · Cited by 134 · see citing works
Sayed, N., Jousselin, A., & Felden, B. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2193 · Cited by 131 · see citing works
Misic, A. M., Davis, M. F., Tyldsley, A. S., Hodkinson, B. P., Tolomeo, P., Hu, B., Nachamkin, I., Lautenbach, E., Morris, D. O., & Grice, E. A. (2015) · Microbiome · doi:10.1186/s40168-014-0052-7 · Cited by 128 · see citing works
Hong, S. W., Choi, E. B., Min, T.-K., Kim, J.-H., Kim, M.-H., Jeon, S. G., Lee, B., Gho, Y. S., Jee, Y., Pyun, B.-Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100499 · Cited by 124 · see citing works
The effects of Staphylococcus aureus leukotoxins on the host: cell lysis and beyond
Yoong, P., & Torres, V. J. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.01.012 · Cited by 124 · see citing works
Wang, F., Fang, R. H., Luk, B. T., Hu, C. J., Thamphiwatana, S., Dehaini, D., Angsantikul, P., Kroll, A. V., Pang, Z., Gao, W., et al. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201505231 · Cited by 122 · see citing works
Nygaard, T. K., Pallister, K. B., Dumont, A., DeWald, M., Watkins, R. L., Pallister, E. Q., Malone, C. L., Griffith, S., Horswill, A. R., Torres, V. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036532 · Cited by 119 · see citing works
Nielsen, A., Månsson, M., Bojer, M. S., Gram, L., Larsen, T. O., Novick, R. P., Frees, D., Frøkiær, H., & Ingmer, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084992 · Cited by 118 · see citing works
Perret, M., Badiou, C., Lina, G., Burbaud, S., Benito, Y., Bes, M., Cottin, V., Couzon, F., Juruj, C., Dauwalder, O., et al. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01772.x · Cited by 116 · see citing works
Rasigade, J., Trouillet‐Assant, S., Ferry, T., Diep, B. A., Sapin, A., Lhoste, Y., Ranfaing, J., Badiou, C., Benito, Y., Bes, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063176 · Cited by 114 · see citing works
Improved understanding of factors driving methicillin-resistant Staphylococcus aureus epidemic waves
Otto, M. J., & Chatterjee (2013) · Clinical Epidemiology · doi:10.2147/clep.s37071 · Cited by 110 · see citing works
Self-citationKane, T., Carothers, K. E., & Lee, S. W. (2018) · Current Drug Targets · doi:10.2174/1389450117666161128123536 · Cited by 108 · see citing works
Anderson, A. S., Miller, A. A., Donald, R. G. K., Scully, I. L., Nanra, J. S., Cooper, D., & Jansen, K. U. (2012) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.21872 · Cited by 107 · see citing works
Bæk, K. T., Gründling, A., Mogensen, R. G., Thøgersen, L., Petersen, A., Paulander, W., & Frees, D. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02802-14 · Cited by 107 · see citing works
Can β-Lactam Antibiotics Be Resurrected to Combat MRSA?
Foster, T. J. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.06.005 · Cited by 106 · see citing works
The function of TLR2 during staphylococcal diseases
Fournier, B. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00167 · Cited by 105 · see citing works
Wall teichoic acids mediate increased virulence in Staphylococcus aureus
Wanner, S., Schade, J., Keinhörster, D., Weller, N., George, S. E., Kull, L., Bauer, J., Grau, T., Winstel, V., Stoy, H., et al. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.257 · Cited by 104 · see citing works
Hardy, B. L., Dickey, S. W., Plaut, R. D., Riggins, D. P., Stibitz, S., Otto, M. J., & Merrell, D. S. (2019) · mBio · doi:10.1128/mbio.02491-18 · Cited by 101 · see citing works
Self-citationThe Microbiome of the Nose—Friend or Foe?
Dimitri‐Pinheiro, S., Soares, R. A., & Barata, P. (2020) · Allergy & Rhinology · doi:10.1177/2152656720911605 · Cited by 101 · see citing works
The role of Staphylococcus aureus quorum sensing in cutaneous and systemic infections
Yamazaki, Y., Ito, T., Tamai, M., Nakagawa, S., & Nakamura, Y. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00323-8 · Cited by 97 · see citing works
Chen, C., Hsu, K., Lin, T., Hwang, K., Chen, P.-Y., & Huang, Y. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01774-10 · Cited by 96 · see citing works
Haunreiter, V. D., Holmes, N., Kiefer, P., Christen, P., Patrignani, A., Vorholt, J. A., Berger‐Bächi, B., & Senn, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073512 · Cited by 95 · see citing works
Distinct Roles of Phenol-Soluble Modulins in Spreading of Staphylococcus aureus on Wet Surfaces
Tsompanidou, E., Denham, E. L., Becher, D., de Jong, A., Buist, G., van Oosten, M., Manson, W. L., Back, J. W., van Dijl, J. M., & Dreisbach, A. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.03157-12 · Cited by 91 · see citing works
In VitroAntimicrobial and Modulatory Activity of the Natural Products Silymarin and Silibinin
de Oliveira, D. R., Tintino, S. R., Morais‐Braga, M. F. B., Boligon, A. A., Athayde, M. L., Coutinho, H. D. M., de Menezes, I. R. A., & Fachinetto, R. (2015) · BioMed Research International · doi:10.1155/2015/292797 · Cited by 87 · see citing works
Pinel‐Marie, M., Brielle, R., & Felden, B. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.012 · Cited by 87 · see citing works
From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence?
Priest, N. K., Rudkin, J., Feil, E. J., van den Elsen, J. M. H., Cheung, A. L., Peacock, S. J., Laabei, M., Lucks, D. A., Recker, M., & Massey, R. C. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2880 · Cited by 85 · see citing works
Kalinka, J., Hachmeister, M., Geraci, J., Sordelli, D. O., Hansen, U. J., Niemann, S., Oetermann, S., Peters, G., Löffler, B., & Tuchscherr, L. P. N. (2014) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2014.07.013 · Cited by 85 · see citing works
Zanger, P., Nurjadi, D., Schleucher, R. D., Scherbaum, H., Wolz, C., Kremsner, P. G., & Schulte, B. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir822 · Cited by 84 · see citing works
Guo, Y., Ramos, R. I., Cho, J. S., Donegan, N. P., Cheung, A. L., & Miller, L. S. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01003-12 · Cited by 83 · see citing works
Isolation and characterization of a new Staphylococcus epidermidis broad-spectrum bacteriophage
Melo, L. D. R., Sillankorva, S., Ackermann, H., Kropinski, A. M., Azeredo, J., & Cerca, N. (2013) · Journal of General Virology · doi:10.1099/vir.0.060590-0 · Cited by 83 · see citing works
Watkins, R., Lemonovich, & File, T. M. (2012) · Core evidence · doi:10.2147/ce.s33430 · Cited by 81 · see citing works
Date, S. V., Modrusan, Z. D., Lawrence, M. F., Morisaki, J. H., Toy, K. J., Shah, I. M., Kim, J., Park, S., Xu, M. J., Basuino, L., et al. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit668 · Cited by 81 · see citing works
Rodríguez‐Rubio, L., Martı́nez, B., Rodrı́guez, A., Donovan, D. M., & García, P. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.07621-11 · Cited by 81 · see citing works
Peng, H., Liu, D., Ma, Y., & Gao, W. (2018) · Scientific Reports · doi:10.1038/s41598-018-36206-5 · Cited by 80 · see citing works
Löffler, B., Niemann, S., Ehrhardt, C., Horn, D., Lanckohr, C., Lina, G., Ludwig, S., & Peters, G. (2013) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2013.827891 · Cited by 79 · see citing works
What Distinguishes Highly Pathogenic Staphylococci from Medium- and Non-pathogenic?
Rosenstein, R., & Götz, F. (2012) · Current topics in microbiology and immunology · doi:10.1007/82_2012_286 · Cited by 79 · see citing works
Laabei, M., Jamieson, W. D., Yang, Y., van den Elsen, J. M. H., & Jenkins, A. T. A. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.08.026 · Cited by 78 · see citing works
Toll-Like Receptors (TLRs) in Innate Immune Defense Against Staphylococcus Aureus
Pietrocola, G., Arciola, C. R., Rindi, S., Poto, A. D., Missineo, A., Montanaro, L., & Speziale, P. (2011) · The International Journal of Artificial Organs · doi:10.5301/ijao.5000030 · Cited by 78 · see citing works
- Authors
- Otto, M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Otto, Michael
- ORCID
- Otto, Michael
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2010-10-13
- Volume
- 64
- Issue
- 1
- Pages
- 143-162
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- OpenAlex
- W2138666908
- Cited by
- 457
- References
- 136
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 17 · 2023: 14 · 2022: 12 · 2021: 24 · 2020: 23 · 2019: 25 · 2018: 30 · 2017: 19 · 2016: 35 · 2015: 33 · 2014: 57 · 2013: 71 · 2012: 47
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- community-associated methicillin-resistant Staphylococcus aureus, virulence factors, USA300, alpha-toxin, phenol-soluble modulins, Panton-Valentine leukocidin, skin and soft tissue infections, virulence evolution, animal models of infection
- MeSH terms
- Animals, Bacterial Proteins, Bacterial Toxins, Disease Models, Animal, Exotoxins, Hemolysin Proteins, Humans, Leukocidins, Staphylococcal Skin Infections, United States, Virulence, Bacteremia, Community-Acquired Infections, Soft Tissue Infections, Virulence Factors, Methicillin-Resistant Staphylococcus aureus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review