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Cited by 50Viral Infections and Immunology ResearchVaccine Coverage and HesitancyVirology and Viral Diseases

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Asymptomatic Wild‐Type Poliovirus Infection in India among Children with Previous Oral Poliovirus Vaccination

Grassly, Nicholas C., Jafari, Hamid, Bahl, Sunil, Durrani, Sunita, Wenger, Jay, Sutter, Roland W., Bruce Aylward, R.·2010·The Journal of Infectious Diseases
DOI 10.1086/651952
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Abstract

BACKGROUND: Mucosal immunity induced by oral poliovirus vaccine (OPV) is imperfect and potentially allows immunized individuals to participate in asymptomatic wild-type poliovirus transmission in settings with efficient fecal-oral transmission of infection. METHODS: We examined the extent of asymptomatic wild-type poliovirus transmission in India by measuring the prevalence of virus in stool samples obtained from 14,005 healthy children who were in contact with 2761 individuals with suspected poliomyelitis reported during the period 2003-2008. RESULTS: Wild-type poliovirus serotypes 1 and 3 were isolated from the stool samples of 103 (0.74%) and 104 (0.74%) healthy contacts, respectively. Among contacts of individuals with laboratory-confirmed poliomyelitis, 27 (12.7%) of 213 and 29 (13.9%) of 209 had serotypes 1 and 3, respectively, isolated from their stool samples. The odds ratio of excreting serotype 1 wild-type poliovirus was 0.13 (95% confidence interval, 0.02-0.87) among healthy children reporting 6 doses of OPV, compared with children reporting 0-2 doses. However, two-thirds of healthy children who excreted this virus reported >or=6 doses, and the prevalence of this virus did not decrease with age over the sampled range. CONCLUSIONS: Although OPV is protective against infection with poliovirus, the majority of healthy contacts who excreted wild-type poliovirus were well vaccinated. This is consistent with a potential role for OPV-vaccinated children in continued wild-type poliovirus transmission and requires further study.

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Research works printed but not linked: 2

  1. [15]15. Grassly NC, Jafari H, Bahl S, et al. Mucosal immunity following vac- cination with monovalent and trivalent oral poliovirus vaccines in India. J Infect Dis 2009; 200:794-801.
  2. [20]20. Gelfand HM, LeBlanc DR, Fox JP, Conwell D. Studies on the devel- opment of natural immunity to poliomyelitis in Louisiana II. Descrip- tion and analysis of infection observed in study group households. Am J Hyg 1957; 65:367-385.

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Metadata

Authors
Grassly, N. C., Jafari, H., Bahl, S., Durrani, S., Wenger, J., Sutter, R. W., & Bruce Aylward, R.
Affiliations
  • Imperial College London (GB)
  • Government of India (IN)
ORCID
Venue
The Journal of Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2010-05-15
Volume
201
Issue
10
Pages
1535-1543
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
DOI
10.1086/651952
OpenAlex
W2124976455
Cited by
50
References
27
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 9 · 2012: 7
FWCI
5.27
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
wild-type poliovirus, asymptomatic infection, oral polio vaccine, mucosal immunity, fecal-oral transmission, serotype 1, serotype 3, vaccination coverage, India
MeSH terms
Child, Preschool, Feces, Humans, India, Infant, Infant, Newborn, Poliomyelitis, Poliovirus Vaccine, Oral, Poliovirus

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