Cited by 167Antibiotic Use and ResistanceAntibiotics Pharmacokinetics and EfficacyHealth Systems, Economic Evaluations, Quality of Life

Outpatient parenteral antimicrobial therapy today

Paladino, Joseph A., Poretz, Donald·2010·Clinical Infectious Diseases

Abstract

Since its introduction in the 1970s, outpatient parenteral antimicrobial therapy (OPAT) has become a standard modality for patients with many infections requiring long-term intravenous antibiotic therapy. Delivery of OPAT may occur in physicians' offices, hospital clinics, specialized infusion centers, and currently most often, patient's homes, often self-administered. Patients are selected for OPAT by physicians familiar with both the course of their infections, their personal suitability for outpatient care, and the availability of reimbursement. OPAT is reportedly safe, effective, practical, and cost-effective. An OPAT Outcomes Registry contains information from >11,000 antibiotic courses administered from 1997 through 2000. Although a number of studies are purported to analyze the economic impact of OPAT on health care, a comprehensive, clinical outcomes-based pharmacoeconomic analysis, as described here, has, to our knowledge, yet to be done.

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Crossref · 10.1086/653520

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Authors
Paladino, J. A., & Poretz, D.
Affiliations
University at Buffalo, State University of New York (US)
Corresponding author
Poretz, Donald
Venue
Clinical Infectious Diseases
Published
2010-09-15
Volume
51
Issue
S2
Pages
S198-S208
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
OpenAlex
W2110987545
Cited by
167
References
42
Citations by year
2026: 4 · 2025: 6 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 5 · 2020: 9 · 2019: 14 · 2018: 16 · 2017: 14 · 2016: 11 · 2015: 22 · 2014: 12 · 2013: 14 · 2012: 6
FWCI
10.60
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
Massachusetts Medical Society
Topics
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Keywords
outpatient parenteral antimicrobial therapy, intravenous antibiotics, home parenteral therapy, self-administered therapy, patient selection, pharmacoeconomics, cost-effectiveness, long-term antibiotic therapy
MeSH terms
Ambulatory Care, Anti-Bacterial Agents, Bacterial Infections, Humans, Infusions, Intravenous, Treatment Outcome, Home Care Services, Hospital-Based

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