Abnormal right ventricular relaxation in pulmonary hypertension.

Murch, Stuart D.; La Gerche, Andre; Roberts, Timothy J.; Prior, David L.; MacIsaac, Andrew I.; Burns, Andrew T.

doi:10.1086/681268

Cited by 53Pulmonary Hypertension Research and TreatmentsCardiovascular Function and Risk FactorsHemodynamic Monitoring and Therapy

Abnormal right ventricular relaxation in pulmonary hypertension.

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Murch, Stuart D., La Gerche, Andre, Roberts, Timothy J., Prior, David L., MacIsaac, Andrew I., Burns, Andrew T.·2015·Pulmonary Circulation

DOI 10.1086/681268PMC PMC4449250

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Abstract

Left ventricular diastolic dysfunction is a well-described complication of systemic hypertension. However, less is known regarding the effect of chronic pressure overload on right ventricular (RV) diastolic function. We hypothesized that pulmonary hypertension (PHT) is associated with abnormal RV early relaxation and that this would be best shown by invasive pressure measurement. Twenty-five patients undergoing right heart catheterization for investigation of breathlessness and/or suspected PHT were studied. In addition to standard measurements, RV pressure was sampled with a high-fidelity micromanometer, and RV pressure/time curves were analyzed. Patients were divided into a PHT group and a non-PHT group on the basis of a derived mean pulmonary artery systolic pressure of 25 mmHg. Eleven patients were classified to the PHT group. This group had significantly higher RV minimum diastolic pressure ([Formula: see text] vs. [Formula: see text] mmHg, [Formula: see text]) and RV end-diastolic pressure (RVEDP; [Formula: see text] vs. [Formula: see text] mmHg, [Formula: see text]), and RV τ was significantly prolonged ([Formula: see text] vs. [Formula: see text] ms, [Formula: see text]). There were strong correlations between RV τ and RV minimum diastolic pressure ([Formula: see text], [Formula: see text]) and between RV τ and RVEDP ([Formula: see text], [Formula: see text]). There was a trend toward increased RV contractility (end-systolic elastance) in the PHT group ([Formula: see text] vs. [Formula: see text] mmHg/mL, [Formula: see text]) and a correlation between RV systolic pressure and first derivative of maximum pressure change ([Formula: see text], [Formula: see text]). Stroke volumes were similar. Invasive measures of RV early relaxation are abnormal in patients with PHT, whereas measured contractility is static or increasing, which suggests that diastolic dysfunction may precede systolic dysfunction. Furthermore, there is a strong association between measures of RV relaxation and RV filling pressures.

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In patients with class II heart failure according to NYHA, systolic/diastolic pulmonary artery pressure values are 35.4 ± 8.8/14.4 ± 5.8 mmHg.
“In patients with class II heart failure according to the New York Heart Association classification, the corresponding values are higher: 35.4 ± 8.8/14.4 ± 5.8 mmHg (Murch et al., 2015)”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Murch et al., 2015
Table 1 reports systolic and diastolic pulmonary artery pressures of 35.4 ± 8.8 and 14.4 ± 5.8 mmHg for the non-pulmonary-hypertension group. The Results say most patients in that group were NYHA class II, but the values are group averages, not measurements specifically for class II heart-failure patients. (LLM, conf=0.90)
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Guidelines for the diagnosis and treatment of pulmonary hypertension
Galiè, N., Hoeper, M. M., Humbert, M. J. C., Torbicki, A., Vachiéry, J., Barberà, J. A., Beghetti, M., Corris, P. A., Gaine, S., Gibbs, J. S. R., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp297 · Cited by 3,841 · see citing works
Survival in Patients with Primary Pulmonary Hypertension
D’Alonzo, G. E., Barst, R. J., Ayres, S. M., Bergofsky, E. H., Brundage, B. H., Detre, K. M., Fishman, A. P., Goldring, R. M., Groves, B. Μ., Kernis, J. T., et al. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-5-343 · Cited by 3,488 · see citing works
Importance of Venous Congestion for Worsening of Renal Function in Advanced Decompensated Heart Failure
Müllens, W., Abrahams, Z., Francis, G. S., Sokos, G. G., Taylor, D. O., Starling, R. C., Young, J. B., & Tang, W. H. W. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.068 · Cited by 1,686 · see citing works
Diastolic Heart Failure — Abnormalities in Active Relaxation and Passive Stiffness of the Left Ventricle
Zile, M. R., Baicu, C. F., & Gaasch, W. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032566 · Cited by 1,556 · see citing works
Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)
Benza, R. L., Miller, D. P., Gomberg-Maitland, M., Frantz, R. P., Foreman, A. J., Coffey, C. S., Frost, A., Barst, R. J., Badesch, D. B., Elliott, C. G., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.898122 · Cited by 1,547 · see citing works
Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era
Humbert, M. J. C., Sitbon, O., Chaouat, A., Bertocchi, M., Habib, G., Gressin, V., Yaïci, A., Weitzenblum, E., Cordier, J.-F., Chabot, F., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.911818 · Cited by 1,394 · see citing works
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment
Borlaug, B. A., & Paulus, W. J. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq426 · Cited by 1,098 · see citing works
Hemodynamic determinants of the time-course of fall in canine left ventricular pressure.
Weiss, J. L., Frederiksen, J. W., & Weisfeldt, M. L. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108522 · Cited by 1,082 · see citing works
Diastolic Heart Failure
Aurigemma, G. P., & Gaasch, W. H. (2004) · New England Journal of Medicine · doi:10.1056/nejmcp022709 · Cited by 759 · see citing works
Comprehensive Invasive and Noninvasive Approach to the Right Ventricle–Pulmonary Circulation Unit
Champion, H. C., Michelakis, E. D., & Hassoun, P. M. (2009) · Circulation · doi:10.1161/circulationaha.106.674028 · Cited by 468 · see citing works
Interventricular Mechanical Asynchrony in Pulmonary Arterial Hypertension
Marcus, J. T., Gan, C. T., Zwanenburg, J. J. M., Boonstra, A., Allaart, C. P., Götte, M., & Noordegraaf, A. V. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.10.041 · Cited by 408 · see citing works
Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension
Rain, S., Handoko, M. L., Trip, P., Gan, C. T., Westerhof, N., Stienen, G. J. M., Paulus, W. J., Ottenheijm, C. A. C., Marcus, J. T., Dorfmüller, P., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.001873 · Cited by 364 · see citing works
Disproportionate exercise load and remodeling of the athlete's right ventricle
LA GERCHE, A., HEIDBÜCHEL, H., BURNS, A. T., MOONEY, D. J., TAYLOR, A. J., PFLUGER, H. B., INDER, W. J., MACISAAC, A. I., & PRIOR, D. L. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31820607a3 · Cited by 347 · see citing works
Self-citation
Single-beat estimation of right ventricular end-systolic pressure-volume relationship
Brimioulle, S., Wauthy, P., Ewalenko, P., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01023.2002 · Cited by 345 · see citing works
Instantaneous pressure-volume relationship of the canine right ventricle.
Maughan, W. L., Shoukas, A. A., SAGAWA, K., et al. (1979) · Circulation Research · doi:10.1161/01.res.44.3.309 · Cited by 314 · see citing works
Diastolic dysfunction
Maurer, M. S., Spevack, D. M., Burkhoff, D., & Kronzon, I. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.07.034 · Cited by 177 · see citing works
Dynamic determinants of letf ventricular diastolic pressure-volume relations in man.
Gaasch, W. H., Cole, J. S., Quiñones, M. A., & Alexander, J. K. (1975) · Circulation · doi:10.1161/01.cir.51.2.317 · Cited by 150 · see citing works
Right Ventricular Diastolic Dysfunction and the Acute Effects of Sildenafil in Pulmonary Hypertension Patients
Gan, C. T., Holverda, S., Marcus, J. T., Paulus, W. J., Marques, K. M., Bronzwaer, J. G. F., Twisk, J. W. R., Boonstra, A., Postmus, P. E., & Noordegraaf, A. V. (2007) · CHEST Journal · doi:10.1378/chest.06-1263 · Cited by 148 · see citing works
Left Ventricular Untwisting Is an Important Determinant of Early Diastolic Function
Burns, A., Gerche, A. L., Prior, D., & MacIsaac, A. I. (2009) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2009.01.015 · Cited by 142 · see citing works
Self-citation
Minimum left ventricular pressure during beta-adrenergic stimulation in human subjects. Evidence for elastic recoil and diastolic "suction" in the normal heart.
Udelson, J. E., Bacharach, S. L., Cannon, R. O., & Bonow, R. O. (1990) · Circulation · doi:10.1161/01.cir.82.4.1174 · Cited by 139 · see citing works
Regional Right Ventricular Dysfunction in Chronic Pulmonary Hypertension
Dambrauskaitė, V. T., Delcroix, M., Claus, P., Herbots, L., D’hooge, J., Bijnens, B. H., Rademakers, F. E., & Sutherland, G. R. (2007) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2007.02.005 · Cited by 124 · see citing works
Role of impaired myocardial relaxation in the production of elevated left ventricular filling pressure
Hay, I., Rich, J. D., Ferber, P., Burkhoff, D., & Maurer, M. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00681.2004 · Cited by 106 · see citing works
Indexes of diastolic RV function: load dependence and changes after chronic RV pressure overload in lambs
Leeuwenburgh, B. P. J., Paul Steendijk, A., Helbing, W. A., & Baan, J. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00782.2001 · Cited by 103 · see citing works
Prolonged right ventricular post-systolic isovolumic period in pulmonary arterial hypertension is not a reflection of diastolic dysfunction
Mauritz, G.-J., Marcus, J. T., Westerhof, N., et al. (2010) · Heart · doi:10.1136/hrt.2010.193375 · Cited by 100 · see citing works
Dynamic determinants of letf ventricular diastolic pressure-volume relations in man.
HGaasch, W., SCole, J., AQuinones, M., et al. (1975) · Circulation · Cited by 90 · see citing works
Describing right ventricular function
Noordegraaf, A. V., & Westerhof, N. (2013) · European Respiratory Journal · doi:10.1183/09031936.00160712 · Cited by 88 · see citing works
Disturbed Right Ventricular Diastolic Function in Patients With Systemic Sclerosis
Lindqvist, P., Caidahl, K., Neuman-Andersen, G., et al. (2005) · CHEST Journal · doi:10.1378/chest.128.2.755 · Cited by 84 · see citing works
Isolated right ventricular dysfunction in systemic sclerosis: latent pulmonary hypertension?
Huez, S., Roufosse, F. E., Vachiéry, J., et al. (2007) · European Respiratory Journal · doi:10.1183/09031936.00025607 · Cited by 73 · see citing works
Distinct loading conditions reveal various patterns of right ventricular adaptation
Borgdorff, M. A. J., Bartelds, B., Dickinson, M. G., et al. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00180.2013 · Cited by 63 · see citing works
Determination of pressure in the pulmonary artery by external graphic recordings.
Burstin, L. (1967) · Heart · doi:10.1136/hrt.29.3.396 · Cited by 63 · see citing works
Matching dicrotic notch and mean pulmonary artery pressures: implications for effective arterial elastance
Chemla, D. S., Hébert, J., Coirault, C., et al. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.4.h1287 · Cited by 57 · see citing works
Right Ventricular Diastolic Performance in Children With Pulmonary Arterial Hypertension Associated With Congenital Heart Disease
Okumura, K., Slorach, C., Mroczek, D., Dragulescu, A., Mertens, L., Redington, A. N., & Friedberg, M. K. (2014) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.001071 · Cited by 56 · see citing works
Negative diastolic pressure in the intact canine right ventricle. Evidence of diastolic suction.
Sabbah, H. N., & Stein, P. D. (1981) · Circulation Research · doi:10.1161/01.res.49.1.108 · Cited by 54 · see citing works
Right ventricular volume measurement by conductance catheter
Danton, M., Greil, G. F., Byrne, J. G., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00048.2003 · Cited by 42 · see citing works
Noninvasive Assessment of the Right Ventricular Filling Pressure Gradient
Cortina, C., Bermejo, J., Yotti, R., Desco, M., Pérez, D. R., Antoranz, J. C., Rojo‐Álvarez, J. L., Garcia, D., Fernández, M. Á. G., & Fernández‐Avilés, F. (2007) · Circulation · doi:10.1161/circulationaha.107.691154 · Cited by 30 · see citing works
Right Ventricular Diastolic Function in Patients With Hypertrophic Cardiomyopathy
Maeda, M., Yamakado, T., & Nakano, T. (1999) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.63.681 · Cited by 23 · see citing works
Absence of right ventricular isovolumic relaxation in open-chest anesthetized dogs
Myhre, E. S. P., Slinker, B. K., & LeWinter, M. M. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.263.5.h1587 · Cited by 22 · see citing works
Effect of Chronic Pressure Overload on the Maximal Rate of Pressure Fall of the Right Ventricle
Stein, P. D., Sabbah, H. N., Mazilli, M., et al. (1980) · CHEST Journal · doi:10.1378/chest.78.1.10 · Cited by 20 · see citing works
Isolated diastolic dysfunction of right ventricle: stress-induced pulmonary hypertension: Table 1—
Faludi, R., Komócsi, A., Bozó, J., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00124207 · Cited by 13 · see citing works

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Vonk-Noordegraaf A, Westerhof N. Describing right ventricular func- tion. Eur Respir J 2013;41:1419-1423.

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Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease
Kutumova, E., Kiselev, I., Sharipov, R., Lifshits, G., & Kolpakov, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746300 · Cited by 16 · see citing works
“8 mmHg (Murch et al., 2015), whereas in patients with pulmonary arterial hypertension these values can achieve 84.”
Background

Effect of Feixinping on ET and NOSmRNA Expression in Pulmonary Artery in Rats with Pulmonary Hypertension in Pulmonary Heart Disease
Li, J. (2009) · Zhonghua zhongyiyao xuekan
Computed tomography measurement of pulmonary artery size in interstitial lung disease to evaluate pulmonary hypertension
Apoorva, B. (2022) · International Journal of Radiology and Diagnostic Imaging · doi:10.33545/26644436.2022.v5.i4b.290
Accuracy of doppler echocardiography in the assessment of pulmonary hypertension in liver transplant candidates
Kim, W. R., Krowka, M. J., Plevak, D. J., Lee, J., Rettke, S. R., Frantz, R. P., & Wiesner, R. H. (2000) · Liver Transplantation · doi:10.1053/jlts.2000.7573 · Cited by 210 · see citing works
[Preliminary criteria for the diagnosis of pulmonary hypertension in mixed connective tissue disease].
Nishimaki, T., Aotsuka, S.-I., Kunieda, T., et al. (1991) · PubMed · Cited by 8 · see citing works
Left Pulmonary Artery Ligation and Chronic Pulmonary Artery Banding Model for Inducing Right Ventricular—Pulmonary Hypertension in Sheep
Ukita, R., Tipograf, Y., Tumen, A., et al. (2020) · ASAIO Journal · doi:10.1097/mat.0000000000001197 · Cited by 11 · see citing works

Authors: Murch, S. D., La Gerche, A., Roberts, T. J., Prior, D. L., MacIsaac, A. I., & Burns, A. T.
Affiliations: The University of Melbourne (AU)
Department of Cardiology St. Vincent's Hospital Melbourne Fitzroy Victoria Australia
Corresponding author: Murch, Stuart D.
ORCID: Prior, David L.
MacIsaac, Andrew I.
Burns, Andrew T.
Venue: Pulmonary Circulation
Publisher: Wiley
Published: 2015-06
Volume: 5
Issue: 2
Pages: 370-375
ISSN: 2045-8932 (ISSN-L)
2045-8940
DOI: 10.1086/681268
PMC: PMC4449250
OpenAlex: W1964647736
Cited by: 53
References: 39
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 4
FWCI: 3.43
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Pulmonary Circulation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Actelion Pharmaceuticals
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Keywords: pulmonary hypertension, right ventricular diastolic dysfunction, end-diastolic pressure, right ventricular filling pressure, end-systolic elastance, right ventricular contractility, pressure-time curve, right heart catheterization, pressure overload

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Abnormal right ventricular relaxation in pulmonary hypertension.

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