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A non-invasive method for focusing ultrasound through the human skull
Open accessAbstract
A technique for focusing ultrasound through the human skull is described and verified. The approach is based on a layered wavevector-frequency domain model, which propagates ultrasound from a hemisphere-shaped transducer through the skull using input from CT scans of the head. The algorithm calculates the driving phase of each transducer element in order to maximize the signal at the intended focus. This approach is tested on ten ex vivo human skulls using a 0.74 MHz, 320-element array. A stereotaxic reference frame is affixed to the skulls in order to provide accurate registration between the CT images and the transducer. The focal quality is assessed with a hydrophone placed inside the skull. In each trial the phase correction algorithm successfully restored the focus inside the skull at a location within 1 mm from the intended focal point. The results demonstrate the feasibility of using the method for completely non-invasive ultrasound brain surgery and therapy.
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Citations
Cited by
The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906
“Ultrasound is a technique that can noninvasively focus deep into the body using an ultrasound field.(219) They are mechanical or elastic vibrations in a medium of a frequency above the range of human hearing (18–20 kHz).”
MethodHynynen, K., McDannold, N., Sheikov, N. A., Jolesz, F. A., & Vykhodtseva, N. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.046 · Cited by 679
Self-citationMcDannold, N., Clement, G. T., Black, P., Jolesz, F., & Hynynen, K. (2010) · Neurosurgery · doi:10.1227/01.neu.0000360379.95800.2f · Cited by 555
Self-citationLow-intensity ultrasound neuromodulation: An overview of mechanisms and emerging human applications
Fomenko, A., Neudorfer, C., Dallapiazza, R. F., Kalia, S. K., & Lozano, A. M. (2018) · Brain Stimulation · doi:10.1016/j.brs.2018.08.013 · Cited by 322
Outcomes from stereotactic surgery for essential tremor
Dallapiazza, R. F., Lee, D. J., De Vloo, P., Fomenko, A., Hamani, C., Hodaie, M., Kalia, S. K., Fasano, A., & Lozano, A. M. (2019) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-318240 · Cited by 233
Metadata
- Authors
- Clement, G. T., & Hynynen, K.
- Venue
- Physics in Medicine and Biology
- Publisher
- IOP Publishing
- Published
- 2002-04-05
- Volume
- 47
- Issue
- 8
- Pages
- 1219-1236
- ISSN
- 0031-9155 (ISSN-L)
- 1361-6560
- OpenAlex
- W2111589632
- Cited by
- 510
- References
- 0
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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