The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
First experimental results of time-of-flight reconstruction on an LSO PET scanner
Abstract
Time-of-flight (TOF) positron emission tomography (PET) was studied and preliminarily developed in the 1980s, but the lack of a scintillator able to deliver at the same time proper time resolution and stopping power has prevented this technique from becoming widespread and commercially available. With the introduction of LSO in PET, TOF is now a feasible option. TOF reconstruction has been implemented in the CPS Hi-Rez PET scanner, both with 2D filtered-back-projection (FBP2D) and 3D ordered subset expectation maximization (OSEM3D). A new procedure has been introduced in the time alignment to compensate for the limited digital time resolution of the present electronics. A preliminary version of scatter correction for TOF has been devised and is presented. The measured time resolution of 1.2 ns (FWHM) allowed for a signal-to-noise ratio increase of about 50% in phantoms of about 40 cm transaxial size, or a gain larger than 2 in noise equivalent counts (NEC). TOF reconstruction has shown the expected improvement in SNR, both in simulation and experimental data. First experimental results show two improvements of TOF reconstruction over conventional (non-TOF) reconstruction: a lower noise level and a better capability to resolve structures deep inside large objects.
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Citations
Cites
Maximum Likelihood Reconstruction for Emission Tomography
Shepp, L. A., & Vardi, Y. (1982) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.1982.4307558 · Cited by 4,429
Cited by
Parodi, K., Paganetti, H., Shih, H. A., Michaud, S., Loeffler, J. S., DeLaney, T. F., Liebsch, N. J., Munzenrider, J. E., Fischman, A. J., Knopf, A., et al. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.01.063 · Cited by 409
Focus on time-of-flight PET: the benefits of improved time resolution
Conti, M. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1711-y · Cited by 335
Self-citationUpdate on time-of-flight PET imaging
Surti, S. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.114.145029 · Cited by 303
Impact of Time-of-Flight on PET Tumor Detection
Kadrmas, D. J., Casey, M. E., Conti, M., Jakoby, B. W., Lois, C., & Townsend, D. W. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.063016 · Cited by 277
Self-citationSurti, S., Scheuermann, J., El Fakhri, G., Daube-Witherspoon, M. E., Lim, R., Abi-Hatem, N., Moussallem, E., Benard, F., Mankoff, D., & Karp, J. S. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.086678 · Cited by 104
Metadata
- Authors
- Conti, M., Bendriem, B., Casey, M., Chen, M., Kehren, F., Michel, C., & Panin, V.
- Venue
- Physics in Medicine and Biology
- Publisher
- IOP Publishing
- Published
- 2005-09-13
- Volume
- 50
- Issue
- 19
- Pages
- 4507-4526
- ISSN
- 0031-9155 (ISSN-L)
- 1361-6560
- OpenAlex
- W2170520519
- Cited by
- 164
- References
- 1
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Conti, M., Bendriem, B., Casey, M., Chen, M., Kehren, F., Michel, C., & Panin, V. (2005). First experimental results of time-of-flight reconstruction on an LSO PET scanner. Physics in Medicine and Biology. https://doi.org/10.1088/0031-9155/50/19/006
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