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Cited by 1,006

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

The physics, biophysics and technology of photodynamic therapy

Open access
Wilson, Brian C, Patterson, Michael S·2008·Physics in Medicine and Biology

Abstract

Photodynamic therapy (PDT) uses light-activated drugs to treat diseases ranging from cancer to age-related macular degeneration and antibiotic-resistant infections. This paper reviews the current status of PDT with an emphasis on the contributions of physics, biophysics and technology, and the challenges remaining in the optimization and adoption of this treatment modality. A theme of the review is the complexity of PDT dosimetry due to the dynamic nature of the three essential components -- light, photosensitizer and oxygen. Considerable progress has been made in understanding the problem and in developing instruments to measure all three, so that optimization of individual PDT treatments is becoming a feasible target. The final section of the review introduces some new frontiers of research including low dose rate (metronomic) PDT, two-photon PDT, activatable PDT molecular beacons and nanoparticle-based PDT.

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Crossref · 10.1088/0031-9155/53/9/r01

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Metadata

Authors
Wilson, B. C., & Patterson, M. S.
Venue
Physics in Medicine and Biology
Published
2008-04-09
Volume
53
Issue
9
Pages
R61-R109
ISSN
  • 0031-9155 (ISSN-L)
  • 1361-6560
OpenAlex
W2050050256
Cited by
1,006
References
7
FWCI
37.56
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: The physics, biophysics and technology of photodynamic therapy. https://app.cochat.ai/papers/10.1088/0031-9155/53/9/r01
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Wilson, B. C., & Patterson, M. S. (2008). The physics, biophysics and technology of photodynamic therapy. Physics in Medicine and Biology. https://doi.org/10.1088/0031-9155/53/9/r01

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.