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Cited by 5,145Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsNonmelanoma Skin Cancer Studies

Photodynamic therapy of cancer: An update

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Agostinis, Patrizia, Berg, Kristian, Cengel, Keith A., Foster, Thomas H., Girotti, Albert W., Gollnick, Sandra O., Hahn, Stephen M., Hamblin, Michael R. +9 more·2011·CA: A Cancer Journal for Clinicians
DOI 10.3322/caac.20114PMC PMC3209659
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Abstract

Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic procedure that can exert a selective cytotoxic activity toward malignant cells. The procedure involves administration of a photosensitizing agent followed by irradiation at a wavelength corresponding to an absorbance band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Clinical studies revealed that PDT can be curative, particularly in early stage tumors. It can prolong survival in patients with inoperable cancers and significantly improve quality of life. Minimal normal tissue toxicity, negligible systemic effects, greatly reduced long-term morbidity, lack of intrinsic or acquired resistance mechanisms, and excellent cosmetic as well as organ function-sparing effects of this treatment make it a valuable therapeutic option for combination treatments. With a number of recent technological improvements, PDT has the potential to become integrated into the mainstream of cancer treatment.

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  • PDT with various photosensitizers has been used in clinical settings for both cancerous and non-cancerous diseases.

    “As a non-invasive therapeutic modality, PDT with various photosensitizers has been used in clinical settings for both cancerous and non-cancerous diseases [14].”

    From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [14]

    The opening passage (labelled Abstract; page unavailable) calls PDT a clinically approved treatment for neoplastic and non-malignant diseases, and the Photosensitizers section describes multiple agents used clinically. However, the paper calls PDT “minimally invasive,” not “non-invasive.” (LLM, conf=0.86)

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Authors
Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., Hahn, S. M., Hamblin, M. R., Juzeniene, A., Kessel, D., Korbelik, M., Moan, J., Mroz, P., Nowis, D., Piette, J., Wilson, B. C., & Golab, J.
Affiliations
  • UCLouvain (BE)
  • Oslo University Hospital (NO)
  • University of Pennsylvania (US)
  • University of Rochester Medicine (US)
  • Medical College of Wisconsin (US)
  • Roswell Park Comprehensive Cancer Center (US)
  • Harvard University (US)
  • Wayne State University (US)
  • BC Cancer Agency (CA)
  • Medical University of Warsaw (PL)
  • University of Liège (BE)
  • University of Toronto (CA)
ORCID
Venue
CA: A Cancer Journal for Clinicians
Publisher
Wiley
Published
2011-05-26
Volume
61
Issue
4
Pages
250-281
ISSN
0007-9235 (ISSN-L)
DOI
10.3322/caac.20114
PMC
PMC3209659
OpenAlex
W2151734986
Cited by
5,145
References
11
Citations by year
2026: 135 · 2025: 373 · 2024: 485 · 2023: 455 · 2022: 492 · 2021: 537 · 2020: 506 · 2019: 445 · 2018: 355 · 2017: 324 · 2016: 296 · 2015: 257 · 2014: 208 · 2013: 142 · 2012: 115
FWCI
25.01
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1 (tdm, 1559 d)
Locations
  • CA A Cancer Journal for Clinicians (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Lirias (submittedVersion)
  • ORBi (University of Liège) (submittedVersion, other-oa)
Funders
  • American Cancer Society
  • Kreftforeningen
  • Australian Government
  • European Commission (POIG.01.01.02-00-008/08)
  • Fundacja na rzecz Nauki Polskiej (CA72630)
  • Fonds Wetenschappelijk Onderzoek (G.0661.09, G.0728.10)
  • Vlaamse regering
  • National Institutes of Health (IAP6/18, CA70823, CA 23378, CA-087971, CA55791)
  • European Regional Development Fund (POIG. 01.01.02-00-008/08)
  • National Heart, Lung, and Blood Institute (R01HL085677)
  • National Cancer Institute (R01CA072630, R01CA023378, P01CA055791, R01CA068409, R01CA122093, P01CA087971, L30 CA136212, R01CA070823, R01CA083882, R01CA098156)
  • National Institute of Allergy and Infectious Diseases (R01AI050875)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
Keywords
photodynamic therapy, photosensitizers, cancer therapy, cancer cell death, inflammation, early-stage cancer, unresectable tumors, quality of life, combination therapy, organ-sparing treatment, treatment toxicity
MeSH terms
Humans, Neoplasms, Photochemotherapy, Photosensitizing Agents

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