The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Biopolymer/montmorillonite nanocomposite: preparation, drug-controlled release property and cytotoxicity
Open accessAbstract
In order to combine the advantages of a biopolymer with clay in a drug delivery system, the hot intercalation technique was used to prepare quaternized chitosan/montmorillonite (HTCC/MMT) nanocomposites. Transmission electron microscopy (TEM), x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) results revealed that HTCC chains entered into the interlayer of MMT, and the interaction between them has taken place. This is the basis of the advantage combination. Then the HTCC/MMT nanocomposites were modified to prepare the nanoparticles, whose drug-controlled release behaviours were evaluated. The results suggested that, compared to pure HTCC nanoparticles, certain montmorillonite loadings on quaternized chitosan enhanced the drug encapsulation efficiency of the nanoparticles and slowed the drug release from the nanocomposites. Finally, a study of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) indicated that the nanocomposites are not cytotoxic. Therefore, the HTCC/MMT nanocomposites are of great potential in the biomedical field.
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Cites
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549
Cited by
Sapsford, K. E., Tyner, K. M., Dair, B. J., Deschamps, J. R., & Medintz, I. L. (2011) · Analytical Chemistry · doi:10.1021/ac200853a · Cited by 538
Combination of Poly(lactic) Acid and Starch for Biodegradable Food Packaging
Muller, J., González-Martínez, C., & Chiralt, A. (2017) · Materials · doi:10.3390/ma10080952 · Cited by 447
Hybrid materials based on clays for environmental and biomedical applications
Ruiz-Hitzky, E., Aranda, P., Darder, M., & Rytwo, G. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm00432d · Cited by 325
Metadata
- Authors
- Wang, X., Du, Y., & Luo, J.
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2008-01-23
- Volume
- 19
- Issue
- 6
- Pages
- 065707
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W2010825248
- Cited by
- 206
- References
- 1
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, X., Du, Y., & Luo, J. (2008). Biopolymer/montmorillonite nanocomposite: preparation, drug-controlled release property and cytotoxicity. Nanotechnology. https://doi.org/10.1088/0957-4484/19/6/065707
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