The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography
Open accessAbstract
Photoacoustic tomography (PAT) is a rapidly emerging non-invasive imaging technology that integrates the merits of high optical contrast with high ultrasound resolution. The ability to quantitatively and non-invasively image nanoparticles has important implications for the development of nanoparticles as in vivo cancer diagnostic and therapeutic agents. In this study, the ability of systemically administered poly(ethylene glycol)-coated (PEGylated) gold nanoparticles as a contrast agent for in vivo tumor imaging with PAT has been evaluated. We demonstrate that gold nanoparticles (20 and 50 nm) have high photoacoustic contrast as compared to mouse tissue ex vivo. Gold nanoparticles can be visualized in mice in vivo following subcutaneous administration using PAT. Following intravenous administration of PEGylated gold nanoparticles to tumor-bearing mice, accumulation of gold nanoparticles in tumors can be effectively imaged with PAT. With gold nanoparticles as a contrast agent, PAT has important potential applications in the image guided therapy of superficial tumors such as breast cancer, melanoma and Merkel cell carcinoma.
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Cites
In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Qian, X., Peng, X.-H., Ansari, D. O., Yin-Goen, Q., Chen, G. Z., Shin, D. M., Yang, L., Young, A. N., Wang, M. D., & Nie, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1377 · Cited by 2,201
Cited by
Kunzmann, A., Andersson, B., Thurnherr, T., Krug, H., Scheynius, A., & Fadeel, B. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.04.007 · Cited by 527
Ultrahigh Sensitivity Carbon Nanotube Agents for Photoacoustic Molecular Imaging in Living Mice
Zerda, A. D. L., Liu, Z., Bodapati, S., Teed, R., Vaithilingam, S., Khuri-Yakub, B. T., Chen, X., Dai, H., & Gambhir, S. S. (2010) · Nano Letters · doi:10.1021/nl100890d · Cited by 396
Metadata
- Authors
- Zhang, Q., Iwakuma, N., Sharma, P., Moudgil, B. M., Wu, C., McNeill, J., Jiang, H., & Grobmyer, S. R.
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2009-09-03
- Volume
- 20
- Issue
- 39
- Pages
- 395102
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W2115639329
- Cited by
- 242
- References
- 1
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, Q., Iwakuma, N., Sharma, P., Moudgil, B. M., Wu, C., McNeill, J., Jiang, H., & Grobmyer, S. R. (2009). Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography. Nanotechnology. https://doi.org/10.1088/0957-4484/20/39/395102
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