The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Biocompatibility of Fe3O4nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells
Abstract
In order to reveal the biocompatibility of Fe(3)O(4) nanoparticles and bipolar surfactant tetramethylammonium 11-aminoundecanoate cytotoxicity tests were performed as a function of concentration from low (0.1 microg ml(-1)) to higher concentration (100 microg ml(-1)) using various human glia, human breast cancer and normal cell lines. Cytotoxicity tests for human glia (D54MG, G9T, SF126, U87, U251, U373), human breast cancer (MB157, SKBR3, T47D) and normal (H184B5F5/M10, WI-38, SVGp12) cell lines exhibited almost nontoxicity and reveal biocompatibility of Fe(3)O(4) nanoparticles in the concentration range of 0.1-10 microg ml(-1), while accountable cytotoxicity can be seen at 100 microg ml(-1). The results of our studies suggest that Fe(3)O(4) nanoparticles coated with bipolar surfactant tetramethylammonium 11-aminoundecanoate are biocompatible and promising for bio-applications such as drug delivery, magnetic resonance imaging and magnetic hyperthermia.
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“In vitro, upon prolonged incubation, surface-coated SPION are typically nontoxic at iron concentration up to and 10 μg/ml, while slight cytotoxicity is seen at 100 μg/ml.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [119]
In the citing paper
“In general, SPION toxicity depends on a variety of factors, including - besides dosing and exposure time - also the nature of the coating material, the hydrodynamic diameter of the particle and SPION-protein interactions [119–122].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [119]
Citations
Cites
Spectrometric Identification of Organic Compounds
Silverstein, R. M., & Bassler, G. C. (1962) · Journal of Chemical Education · doi:10.1021/ed039p546 · Cited by 14,272
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
Vogel's Textbook of Practical Organic Chemistry
Vogel, A. I., & Furniss, B. S. (2003) · Cited by 6,769
Applications of magnetic nanoparticles in biomedicine
Pankhurst, Q. A., Connolly, J., Jones, S. K., & Dobson, J. (2003) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/36/13/201 · Cited by 5,974
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Hirsch, L. R., Stafford, R. J., Bankson, J. A., Sershen, S. R., Rivera, B., Price, R. E., Hazle, J. D., Halas, N. J., & West, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232479100 · Cited by 3,961
A Text-Book of Practical Organic Chemistry
Cook, J. W. (1948) · Nature · doi:10.1038/161995c0 · Cited by 3,497
Monodisperse MFe2O4 (M = Fe, Co, Mn) Nanoparticles
Sun, S., Zeng, H., Robinson, D., Raoux, S., Rice, P. M., Wang, S. X., & Li, G. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0380852 · Cited by 3,484
The use of nanocrystals in biological detection
Alivisatos, A. P. (2003) · Nature Biotechnology · doi:10.1038/nbt927 · Cited by 3,006
Spectrometric Identification of Organic Compounds
Small, G. W. (1992) · Vibrational Spectroscopy · doi:10.1016/0924-2031(92)87024-a · Cited by 2,814
Wu, X., Liu, H., Liu, J., Haley, K. N., Treadway, J. A., Larson, J., Ge, N., Peale, F., & Bruchez, M. P. (2002) · Nature Biotechnology · doi:10.1038/nbt764 · Cited by 2,506
Research works printed but not linked: 2
- Kircher M F, 2002, Radiology, 225, 453
- Predoi D, 2007, J. Optoelect. Adv. Mater., 9, 3609
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION)
Singh, N., Jenkins, G. J. S., Asadi, R., & Doak, S. H. (2010) · Nano Reviews · doi:10.3402/nano.v1i0.5358 · Cited by 1,112
Chen, Z., Yin, J., Zhou, Y., Zhang, Y., Song, L., Song, M., Hu, S., & Gu, N. (2012) · ACS Nano · doi:10.1021/nn300291r · Cited by 945
Nanozyme for tumor therapy: Surface modification matters
Tang, G., He, J., Liu, J., Yan, X., & Fan, K. (2021) · Exploration · doi:10.1002/exp.20210005 · Cited by 444
Laurent, S., Saei, A. A., Behzadi, S., Panahifar, A., & Mahmoudi, M. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.924501 · Cited by 454
Metadata
- Authors
- Ankamwar, B., Lai, T. C., Huang, J. H., Liu, R. S., Hsiao, M., Chen, C. H., & Hwu, Y. K.
- Affiliations
- National Taiwan University (TW)
- Genomics Research Center, Academia Sinica (TW)
- Institute of Physics, Academia Sinica (TW)
- Corresponding author
- Liu, R S
- Venue
- Nanotechnology
- Publisher
- IOP Publishing
- Published
- 2010-01-21
- Volume
- 21
- Issue
- 7
- Pages
- 075102
- ISSN
- 0957-4484 (ISSN-L)
- 1361-6528
- OpenAlex
- W2073884591
- Cited by
- 267
- References
- 42
- Citations by year
- 2026: 1 · 2025: 14 · 2024: 15 · 2023: 15 · 2022: 17 · 2021: 29 · 2020: 17 · 2019: 23 · 2018: 21 · 2017: 18 · 2016: 20 · 2015: 20 · 2014: 21 · 2013: 16 · 2012: 11
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- Fe3O4 nanoparticles, magnetic nanoparticles, biocompatibility, cytotoxicity, glial cells, breast cancer cells, surfactant coating, drug delivery, magnetic hyperthermia, magnetic resonance imaging
- MeSH terms
- Amino Acids, Quaternary Ammonium Compounds, Biocompatible Materials, Breast, Breast Neoplasms, Cell Line, Cell Survival, Female, Ferric Compounds, Humans, Materials Testing, Microscopy, Neuroglia, Surface-Active Agents, Cell Line, Tumor, Metal Nanoparticles
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