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Analysis of electroencephalograms in Alzheimer's disease patients with multiscale entropy

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Escudero, J, Abásolo, D, Hornero, R, Espino, P, López, M·2006·Physiological Measurement

Abstract

The aim of this study was to analyse the electroencephalogram (EEG) background activity of Alzheimer's disease (AD) patients using multiscale entropy (MSE). MSE is a recently developed method that quantifies the regularity of a signal on different time scales. These time scales are inspected by means of several coarse-grained sequences formed from the analysed signals. We recorded the EEGs from 19 scalp electrodes in 11 AD patients and 11 age-matched controls and estimated the MSE profile for each epoch of the EEG recordings. The shape of the MSE profiles reveals the EEG complexity, and it suggests that the EEG contains information in deeper scales than the smallest one. Moreover, the results showed that the EEG background activity is less complex in AD patients than control subjects. We found significant differences between both subject groups at electrodes F3, F7, Fp1, Fp2, T5, T6, P3, P4, O1 and O2 (p-value < 0.01, Student's t-test). These findings indicate that the EEG complexity analysis performed on deeper time scales by MSE may be a useful tool in order to increase our knowledge of AD.

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Metadata

Authors
Escudero, J., Abásolo, D., Hornero, R., Espino, P., & López, M.
Venue
Physiological Measurement
Published
2006-09-12
Volume
27
Issue
11
Pages
1091-1106
ISSN
  • 0967-3334 (ISSN-L)
  • 1361-6579
OpenAlex
W2113651175
Cited by
264
References
49
FWCI
3.38
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Analysis of electroencephalograms in Alzheimer's disease patients with multiscale entropy. https://app.cochat.ai/papers/10.1088/0967-3334/27/11/004
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Escudero, J., Abásolo, D., Hornero, R., Espino, P., & López, M. (2006). Analysis of electroencephalograms in Alzheimer's disease patients with multiscale entropy. Physiological Measurement. https://doi.org/10.1088/0967-3334/27/11/004

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