Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia
Abstract
Schizophrenia has been associated with autonomic dysregulation and increased cardiovascular co-morbidity. We hypothesised that autonomic dysregulation in patients with schizophrenia is associated with psychopathology and metabolic profiles. In this study, we aimed to evaluate psychopathology, comprehensive metabolic profiles and cardiac autonomic function using heart-rate variability (HRV) analysis in patients with schizophrenia. A total of 94 patients with schizophrenia and 51 healthy controls were recruited. Each patient underwent a physical examination, laboratory tests and rating scale evaluation, and all subjects underwent a 1-h electrocardiogram monitoring. Analysis of variance was used to compare demographic and HRV variables between control and patient groups. We applied multiple regression analysis with backward selection to examine the association between HRV indices and demographic, metabolic and psychopathology profiles. A decreased HRV was found in patient groups, compared to controls. Reduced vagal-related and complexity domain of HRV indices in patient groups were correlated with increased body mass indices, diastolic pressure, triglycerides, high- and low-density lipoprotein and severity of psychosis mainly in the negative symptom domain. This study provides evidence that altered autonomic function is associated with both psychopathology and metabolic profiles in patients with schizophrenia. These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia.
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Patients with schizophrenia have relatively preserved sympathetic functioning and do not differ significantly from healthy controls.
“Consistent with the findings of several previous studies31–34, these results imply that patients with SCZ have relatively preserved sympathetic functioning and do not differ significantly with HCs.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [34]
The negative symptom domain of the PANSS is inversely related to parasympathetic HRV parameters RMSSD and HF and positively associated with the LF/HF ratio.
“Elsewhere, the negative symptom domain of the PANSS, which focuses largely on distortions in emotional, social and thinking processes, was inversely related to parasympathetic HRV parameters RMSSD34 and HF28,34,61 and positively associated with the LF/HF ratio34;”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [34]
These findings have also been replicated in a group of schizophrenia patients.
“These findings have also been replicated in a group of SCZ patients (see Supplementary Table 3)34,89.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [34]
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- Authors
- Chung, M.-S., Yang, A. C., Lin, Y.-C., Lin, C.-N., Chang, F.-R., Shen, S.-H., Ouyang, W.-C., Loh, E.-W., & Chiu, H.-J.
- Affiliations
- Jianan Mental Hospital (TW)
- National Central University (TW)
- National Health Research Institutes (TW)
- Min Sheng General Hospital (TW)
- Corresponding author
- Chiu, Hsien-Jane
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 210
- Issue
- 3
- Pages
- 710-715
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2148460315
- Cited by
- 34
- References
- 67
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 4
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council of Taiwan (NSC 95–2314-B-075–111)
- NSC support for the Center for Dynamical Biomarkers and Translational Medicine, National Central University, Taiwan (NSC 101–2911-I-008-001)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- schizophrenia, cardiac autonomic function, heart rate variability, autonomic dysfunction, psychopathology, metabolic profile, body mass index, cardiovascular comorbidity, negative symptoms, psychosis severity, triglycerides, lipoproteins, diastolic blood pressure, parasympathetic activity
- MeSH terms
- Adult, Autonomic Nervous System, Blood Glucose, Blood Pressure, C-Reactive Protein, Electrocardiography, Female, Heart Rate, Humans, Lipoproteins, HDL, Male, Middle Aged, Psychopathology, Schizophrenia, Taiwan, Triglycerides, Linear Models, Case-Control Studies, Metabolic Syndrome, Metabolome
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