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Performance evaluation of the MOLECUBES β -CUBE—a high spatial resolution and high sensitivity small animal PET scanner utilizing monolithic LYSO scintillation detectors
Open accessAbstract
The MOLECUBES β -CUBE scanner is the newest amongst commercially available preclinical PET scanners for dedicated small animal imaging. The scanner is compact, lightweight and utilizes a small footprint to facilitate bench-top imaging. It can be used individually, or in combination with the X-CUBE CT scanner, which provides the ability to perform all necessary PET data corrections and provide fully quantitative PET images. The PET detector comprises of an 8 mm thick monolithic LYSO scintillator read-out by an array of 3 mm × 3 mm Hamamatsu silicon photomultipliers. The monolithic scintillator provides the ability to measure depth-of-interaction which aids in the development of such a compact scanner. With a scanner diameter of 7.6 cm and axial length of 13 cm it is suitable for imaging both whole-body mice and rats. This paper presents the design and imaging performance of the β -CUBE scanner. NEMA NU4-2008 characterization and a variety of phantom and animal imaging studies to demonstrate the quantitative imaging performance of the PET scanner are presented. Spatial resolution of 1 mm is measured with a filtered-back projection reconstruction algorithm at the center of the scanner and DOI measurement helps maintain the excellent spatial resolution over the entire imaging FOV. An absolute peak sensitivity of 12.4% is measured with a 255–765 keV energy window. The scanner demonstrates good count-rate performance, with a peak NEC of 300 kcps and 160 kcps measured with ~900 µ Ci in the NEMA mouse and rat phantoms, respectively. Imaging data with the NEMA image quality phantom and Micro Derenzo phantoms demonstrate the ability to achieve good image quality and accurate quantitative data. Image uniformity of 7.4% and spill-over ratio of 8% were measured. The superior spatial resolution, excellent energy resolution and sensitivity also provide superior contrast recovery, with ~70% recovery for the 2 mm rods. While current commercial preclinical PET scanners have spatial resolution in the 1–2 mm range, the 1 mm 3 volumetric resolution presents significant improvement over current commercially available preclinical PET scanners. In combination with the X-CUBE scanner it provides the ability to perform fully quantitative imaging with spatially co-registered high-resolution 3D PET-CT images.
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“In all cases, images were corrected for radionuclide decay, tissue attenuation, detector dead-time loss, and photon scatter according to the manufacturer’s methods (Krishnamoorthy et al., 2018).”
From Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice (2022) · cites this paper as Krishnamoorthy et al., 2018
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Cites
MicroPET: a high resolution PET scanner for imaging small animals
Cherry, S. R., Shao, Y., Silverman, R. W., Meadors, K., Siegel, S. B., Chatziioannou, A. F., Young, J. W., Jones, W., Moyers, J. C., Newport, D. F., et al. (1997) · IEEE Transactions on Nuclear Science · doi:10.1109/23.596981 · Cited by 611
Strother, S. C., Casey, M., & Hoffman, E. J. (1990) · IEEE Transactions on Nuclear Science · doi:10.1109/23.106715 · Cited by 549
Burger, C., Goerres, G. W., Schoenes, S., Buck, A., Lonn, A. H. R., & von Schulthess, G. K. (2002) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-0796-3 · Cited by 429
Treatment of axial data in three-dimensional PET.
Daube-Witherspoon, M. E., & Muehllehner, G. (1987) · PubMed · Cited by 357
Chatziioannou, A. F., Cherry, S. R., Shao, Y., Silverman, R. W., Meadors, K., Farquhar, T. H., Pedarsani, M., & Phelps, M. E. (1999) · PubMed · Cited by 347
A Single Scatter Simulation Technique for Scatter Correction in 3D PET
Watson, C. C., Newport, D. F., & Casey, M. (1996) · Computational imaging and vision · doi:10.1007/978-94-015-8749-5_18 · Cited by 342
Bao, Q., Newport, D. F., Chen, M., Stout, D. B., & Chatziioannou, A. F. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.056374 · Cited by 306
Performance evaluation of the GE healthcare eXplore VISTA dual-ring small-animal PET scanner.
Wang, Y., Seidel, J., Tsui, B. M. W., Vaquero, J. J., & Pomper, M. G. (2006) · PubMed · Cited by 289
A novel, SiPM-array-based, monolithic scintillator detector for PET
Schaart, D. R., van Dam, H. T., Seifert, S., Vinke, R., Dendooven, P. G., Löhner, H., & Beekman, F. J. (2009) · Physics in Medicine and Biology · doi:10.1088/0031-9155/54/11/015 · Cited by 286
Tai, Y., Chatziioannou, A. F., Yang, Y., Silverman, R. W., Meadors, K., Siegel, S. B., Newport, D. F., Stickel, J. R., & Cherry, S. R. (2003) · Physics in Medicine and Biology · doi:10.1088/0031-9155/48/11/303 · Cited by 275
A 3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals
Jeavons, A. P., Chandler, R., & Dettmar, C. A. R. (1999) · IEEE Transactions on Nuclear Science · doi:10.1109/23.775564 · Cited by 259
Performance evaluation of the microPET R4 PET scanner for rodents
Knoess, C., Siegel, S. B., Smith, A. M., Newport, D. F., Richerzhagen, N., Winkeler, A., Jacobs, A. H., Goble, R. N., Graf, R., Wienhard, K., et al. (2003) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-1052-6 · Cited by 257
Studies of a Next-Generation Silicon-Photomultiplier–Based Time-of-Flight PET/CT System
Hsu, D. F. C., Ilan, E., Peterson, W. T., Uribe, J., Lubberink, M., & Levin, C. S. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.189514 · Cited by 241
NEMA NU 4-2008 Comparison of Preclinical PET Imaging Systems
Goertzen, A. L., Bao, Q., Bergeron, M., Blankemeyer, E. R., Blinder, S. A. L., Cañadas, M., Chatziioannou, A. F., Dinelle, K., Elhami, E., Jans, H.-S., et al. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.099382 · Cited by 238
Self-citationDepth of interaction decoding of a continuous crystal detector module
Ling, T., Lewellen, T. K., & Miyaoka, R. S. (2007) · Physics in Medicine and Biology · doi:10.1088/0031-9155/52/8/012 · Cited by 185
cMiCE: a high resolution animal PET using continuous LSO with a statistics based positioning scheme
Joung, J., Miyaoka, R. S., & Lewellen, T. K. (2002) · Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment · doi:10.1016/s0168-9002(02)00861-6 · Cited by 164
Performance Evaluation of the LabPET APD-Based Digital PET Scanner
Bergeron, M., Cadorette, J., Beaudoin, J.-F., Lepage, M. D., Robert, G., Selivanov, V. V., Tétrault, M., Viscogliosi, N., Norenberg, J. P., Fontaine, R., et al. (2009) · IEEE Transactions on Nuclear Science · doi:10.1109/tns.2008.2010257 · Cited by 155
Performance measurements of small animal positron emission tomographs.
Weber, S., & Bruyndonckx, P. (2002) · JuSER (Forschungszentrum Jülich) · Cited by 154
Performance Evaluation of the Small-Animal nanoScan PET/MRI System
Nagy, K. L., Tóth, M., Major, P., Patay, G., Egri, G., Häggkvist, J., Varrone, A., Farde, L., Halldin, C., & Gulyás, B. Z. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.119065 · Cited by 134
Szanda, I., Mackewn, J. E., Patay, G., Major, P., Sunassee, K., Mullen, G. E. D., Nemeth, G., Hämisch, Y., Blower, P. J., & Marsden, P. K. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.088260 · Cited by 132
España, S., Marcinkowski, R., Keereman, V., Vandenberghe, S., & Holen, R. V. (2014) · Physics in Medicine and Biology · doi:10.1088/0031-9155/59/13/3405 · Cited by 110
Design and engineering aspects of a high resolution positron tomograph for small animal imaging
Lecomte, R., Cadorette, J., Richard, P., Rodrigue, S., & Rouleau, D. (1994) · IEEE Transactions on Nuclear Science · doi:10.1109/23.322930 · Cited by 107
Seifert, S., van der Lei, G., van Dam, H. T., & Schaart, D. R. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/9/3061 · Cited by 106
Performance evaluation of the Philips MOSAIC small animal PET scanner
Huisman, M. C., Reder, S., Weber, A. W., Ziegler, S. I., & Schwaiger, M. (2006) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-006-0271-7 · Cited by 104
Kwon, S. I., Lee, J. S., Yoon, H. S., Ito, M., Ko, G. B., Choi, J. Y., Lee, S.-H., Song, I. C., Jeong, J. M., Lee, D. S., et al. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.079707 · Cited by 101
Imaging performance of a-PET: a small animal PET camera
Surti, S., Karp, J. S., Perkins, A. E., Cardi, C. A., Daube-Witherspoon, M. E., Kuhn, A., & Muehllehner, G. (2005) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2005.844078 · Cited by 98
Self-citationMaas, M. C., van der Laan, D. J., Schaart, D. R., Huizenga, J., Brouwer, J. C., Bruyndonckx, P., Leonard, S., Lemaître, C., & van Eijk, C. W. E. (2006) · IEEE Transactions on Nuclear Science · doi:10.1109/tns.2006.873711 · Cited by 78
Borghi, G., Peet, B. J., Tabacchini, V., & Schaart, D. R. (2016) · Physics in Medicine and Biology · doi:10.1088/0031-9155/61/13/4929 · Cited by 69
Characterization of the Vereos Digital Photon Counting PET System
Miller, M. A., Zhang, J., Binzel, K., Griesmer, J. J., Laurence, T., Narayanan, M. V., Natarajamani, D., Wang, S., & Knopp, M. V. (2015) · Journal of Nuclear Medicine · Cited by 68
Wehner, J., Weissler, B., Dueppenbecker, P. M., Gebhardt, P., Goldschmidt, B., Schug, D., Kiessling, F. M., & Schulz, V. (2015) · Physics in Medicine and Biology · doi:10.1088/0031-9155/60/6/2231 · Cited by 65
First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner
Ishii, K., Kikuchi, Y., Matsuyama, S., Kanai, Y., Kotani, K., Itô, T., Yamazaki, H., Funaki, Y., Iwata, R., Itoh, M., et al. (2007) · Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment · doi:10.1016/j.nima.2007.03.018 · Cited by 58
Performance Evaluation of PETbox: A Low Cost Bench Top Preclinical PET Scanner
Zhang, H., Bao, Q., Vu, N. T., Silverman, R. W., Taschereau, R., Berry-Pusey, B. N., Douraghy, A., Rannou, F. R., Stout, D. B., & Chatziioannou, A. F. (2010) · Molecular Imaging and Biology · doi:10.1007/s11307-010-0413-y · Cited by 54
Degenhardt, C., Rodrigues, P., Trindade, A., Zwaans, B., Muelhens, O., Dorscheid, R., Thon, A., Salomon, A., & Frach, T. (2012) · IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) · doi:10.1109/nssmic.2012.6551643 · Cited by 47
Walker, M. D., Goorden, M. C., Dinelle, K., Ramakers, R. M., Blinder, S. A. L., Shirmohammad, M., van der Have, F., Beekman, F. J., & Sossi, V. (2014) · Journal of Nuclear Medicine · doi:10.2967/jnumed.113.136663 · Cited by 44
Performance evaluation of the small-animal PET scanner ClairvivoPET using NEMA NU 4-2008 Standards
Sato, K., Shidahara, M., Watabe, H., Watanuki, S., Ishikawa, Y., Arakawa, Y., Nai, Y., Furumoto, S., Tashiro, M., Shoji, T., et al. (2015) · Physics in Medicine and Biology · doi:10.1088/0031-9155/61/2/696 · Cited by 41
Bruyndonckx, P., Leonard, S., Liu, J., Tavernier, S., Szupryczynski, P., & Fedorov, A. (2003) · IEEE Transactions on Nuclear Science · doi:10.1109/tns.2003.817348 · Cited by 41
Park, S.-J., Rogers, W. L., Huh, S. S., Kagan, H., Honscheid, K., Burdette, D. J., Chesi, E., Lacasta, C., Llosa, G., Mikuž, M., et al. (2007) · Physics in Medicine and Biology · doi:10.1088/0031-9155/52/10/012 · Cited by 38
Repeatability of 18F-FLT PET in a Multicenter Study of Patients with High-Grade Glioma
Lodge, M. A., Holdhoff, M., Leal, J. P., Bag, A. K., Nabors, B., Mintz, A., Lesser, G. J., Mankoff, D. A., Desai, A. S., Mountz, J. M., et al. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.178434 · Cited by 32
Quantitative PET and SPECT performance characteristics of the Albira Trimodal pre-clinical tomograph
Spinks, T. J., Karia, D., Leach, M. O., & Flux, G. (2014) · Physics in Medicine and Biology · doi:10.1088/0031-9155/59/3/715 · Cited by 30
Kaul, M., Surti, S., & Karp, J. S. (2013) · IEEE Transactions on Nuclear Science · doi:10.1109/tns.2013.2240315 · Cited by 26
Self-citationEvaluation of pixelated NaI(Tl) detectors for PET
Surti, S., Karp, J. S., & Muehllehner, G. (2003) · IEEE Transactions on Nuclear Science · doi:10.1109/tns.2002.807914 · Cited by 20
Self-citationBasic Performance Test of a Prototype PET Scanner Using CdTe Semiconductor Detectors
Ueno, Y., Morimoto, Y., Tsuchiya, K., Yanagita, N., Kojima, S., Ishitsu, T., Kitaguchi, H., Kubo, N., Zhao, S., Tamaki, N., et al. (2009) · IEEE Transactions on Nuclear Science · doi:10.1109/tns.2008.2004804 · Cited by 18
An improved anger detector approach for PET with high resolution and sensitivity
Vaska, P., Krishnamoorthy, S. V., Stoll, S. P., Woody, C. L., O'Connor, P., Purschke, M. L., Boose, S., Schlyer, D. J., & Villanueva, A. (2005) · IEEE Symposium Conference Record Nuclear Science 2004. · doi:10.1109/nssmic.2004.1466632 · Cited by 11
Self-citationUltra-high resolution PET: A CZT-based scanner for the mouse brain
Vaska, P., Kim, D. H., Southekal, S. S., Pratte, J. ‐., Fried, J., Krishnamoorthy, S., Stoll, S. P., & Bolotnikov, A. E. (2009) · Journal of Nuclear Medicine · Cited by 6
Self-citation
Research works printed but not linked: 2
- Casey, 2017, A next generation SiPM based PET/CT system with improved time and spatial resolution, J. Nucl. Med., 58, 1332S
- Mollet, 2017, The β-CUBE, a high-end compact preclinical benchtop PET for total body imaging, J. Nucl. Med., 58, 393S
Cited by
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Vandenberghe, S., Moskal, P., & Karp, J. S. (2020) · EJNMMI Physics · doi:10.1186/s40658-020-00290-2 · Cited by 394
Self-citationPhysics and technology of time-of-flight PET detectors
Schaart, D. R. (2021) · Physics in Medicine and Biology · doi:10.1088/1361-6560/abee56 · Cited by 147
Evolution of PET Detectors and Event Positioning Algorithms Using Monolithic Scintillation Crystals
González-Montoro, A., González, A. J., Pourashraf, S., Miyaoka, R. S., Bruyndonckx, P., Chinn, G., Pierce, L. A., & Levin, C. S. (2021) · IEEE Transactions on Radiation and Plasma Medical Sciences · doi:10.1109/trpms.2021.3059181 · Cited by 113
Update on latest advances in time-of-flight PET
Surti, S., & Karp, J. S. (2020) · Physica Medica · doi:10.1016/j.ejmp.2020.10.031 · Cited by 96
Self-citationSmall animal PET: a review of what we have done and where we are going
Miyaoka, R. S., & Lehnert, A. L. (2020) · Physics in Medicine and Biology · doi:10.1088/1361-6560/ab8f71 · Cited by 92
Metadata
- Authors
- Krishnamoorthy, S., Blankemeyer, E., Mollet, P., Surti, S., Van Holen, R., & Karp, J. S.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Krishnamoorthy, Srilalan
- Venue
- Physics in Medicine & Biology
- Publisher
- IOP Publishing
- Published
- 2018-07-27
- Volume
- 63
- Issue
- 15
- Pages
- 155013
- ISSN
- 0031-9155 (ISSN-L)
- 1361-6560
- PMC
- PMC6145835
- OpenAlex
- W2810955814
- Cited by
- 141
- References
- 44
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 19 · 2023: 13 · 2022: 19 · 2021: 28 · 2020: 22 · 2019: 14 · 2018: 4
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Physics in Medicine and Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01-CA113941)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Detection and Scintillator Technologies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- small animal imaging, silicon photomultipliers, spatial resolution, count rate performance, PET quantification, PET/CT, image quality, contrast recovery, rats and mice
- MeSH terms
- Animals, Scintillation Counting, Sensitivity and Specificity, Phantoms, Imaging, Positron-Emission Tomography, Mice, Rats
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