Performance evaluation of the mouse version of the LabPET II PET scanner
Open accessAbstract
The LabPET II is a new positron emission tomography technology platform designed to achieve submillimetric spatial resolution imaging using fully pixelated avalanche photodiodes-based detectors and highly integrated parallel front-end processing electronics. The detector was designed as a generic building block to develop devices for preclinical imaging of small to mid-sized animals and for clinical imaging of the human brain. The aim of this work is to assess the physical characteristics and imaging performance of the mouse version of LabPET II scanner following the NEMA NU4-2008 standard and using high resolution phantoms and in vivo imaging applications. A reconstructed spatial resolution of 0.78 mm (0.5 μ l ) is measured close to the center of the radial field of view. With an energy window of 350 650 keV, the system absolute sensitivity is 1.2% and its maximum noise equivalent count rate reaches 61.1 kcps at 117 MBq. Submillimetric spatial resolution is achieved in a hot spot phantom and tiny bone structures were resolved with unprecedented contrast in the mouse. These results provide convincing evidence of the capabilities of the LabPET II technology for biomolecular imaging in preclinical research.
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The best spatial resolution of small-animal PET scanners is 1-1.5 mm.
“the best resolution is still 1-1.5 mm [153].”
From Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression (2025) · cites this paper as [153]
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Flagged first, then by citations
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Toyonaga, T., Fesharaki-Zadeh, A., Strittmatter, S. M., Carson, R. E., & Cai, Z. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.787404 · Cited by 20 · see citing works
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- Authors
- Gaudin, É., Thibaudeau, C., Arpin, L., Leroux, J.-D., Toussaint, M., Beaudoin, J.-F., Cadorette, J., Paillé, M., Pepin, C. M., Koua, K., Bouchard, J., Viscogliosi, N., Paulin, C., Fontaine, R., & Lecomte, R.
- Affiliations
- Université de Sherbrooke (CA)
- IR&T Inc., Sherbrooke, QC,
- Novalgo Inc., Sherbrooke, QC,
- Sherbrooke Molecular Imaging Center and Department of Nuclear Medicine and Radiobiology, Université de Sherbrooke, Sherbrooke, QC,
- ORCID
- Venue
- Physics in Medicine & Biology
- Publisher
- IOP Publishing
- Published
- 2021-03-08
- Volume
- 66
- Issue
- 6
- Pages
- 065019
- ISSN
- 0031-9155 (ISSN-L)
- 1361-6560
- PMC
- PMC7979522
- OpenAlex
- W3118791832
- Cited by
- 16
- References
- 40
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 2
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Physics in Medicine and Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Detection and Scintillator Technologies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- positron emission tomography, small animal imaging, mouse imaging, noise equivalent count rate, absolute sensitivity, bone imaging, biomolecular imaging
- MeSH terms
- Animals, Brain, Calibration, Electronics, Equipment Design, Humans, Image Processing, Computer-Assisted, Sensitivity and Specificity, Reproducibility of Results, Phantoms, Imaging, Fluorodeoxyglucose F18, Imaging, Three-Dimensional, Positron-Emission Tomography, Mice, Whole Body Imaging
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