The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film
Open accessAbstract
Conductive polymer coatings can be used to modify traditional electrode recording sites with the intent of improving the long-term performance of cortical microelectrodes. Conductive polymers can drastically decrease recording site impedance, which in turn is hypothesized to reduce thermal noise and signal loss through shunt pathways. Moreover, conductive polymers can be seeded with agents aimed at promoting neural growth toward the recording sites or minimizing the inherent immune response. The end goal of these efforts is to generate an ideal long-term interface between the recording electrode and surrounding tissue. The goal of this study was to refine a method to electrochemically deposit surfactant-templated ordered poly(3,4-ethylenedioxythiophene) (PEDOT) films on the recording sites of standard 'Michigan' probes and to evaluate the efficacy of these modified sites in recording chronic neural activity. PEDOT-coated site performance was compared to control sites over a six-week evaluation period in terms of impedance spectroscopy, signal-to-noise ratio, number of viable unit potentials recorded and local field potential recordings. PEDOT sites were found to outperform control sites with respect to signal-to-noise ratio and number of viable unit potentials. The benefit of reduced initial impedance, however, was mitigated by the impedance contribution of typical silicon electrode encapsulation. Coating sites with PEDOT also reduced the amount of low-frequency drift evident in local field potential recordings. These findings indicate that electrode sites electrochemically deposited with PEDOT films are suitable for recording neural activity in vivo for extended periods. This study also provided a unique opportunity to monitor how neural recording characteristics develop over the six weeks following implantation.
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Cites
Pattern Recognition with Fuzzy Objective Function Algorithms
Bezdek, J. C. (1981) · doi:10.1007/978-1-4757-0450-1 · Cited by 9,881
A Fuzzy Relative of the ISODATA Process and Its Use in Detecting Compact Well-Separated Clusters
Dunn, J. C. (1973) · Journal of Cybernetics · doi:10.1080/01969727308546046 · Cited by 5,049
Response of brain tissue to chronically implanted neural electrodes
Polikov, V. S., Tresco, P. A., & Reichert, W. M. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.08.015 · Cited by 1,896
Learning to control a brain–machine interface for reaching and grasping by primates
Carmena, J. M., Lebedev, M. A., Crist, R. E., O'Doherty, J. E., Santucci, D. M., Dimitrov, D. F., Patil, P. G., Henriquez, C. S., & Nicolelis, M. A. L. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000042 · Cited by 1,761
Instant neural control of a movement signal
Serruya, M. D., Hatsopoulos, N. G., Paninski, L., Fellows, M. R., & Donoghue, J. P. (2002) · Nature · doi:10.1038/416141a · Cited by 1,415
A review of methods for spike sorting: the detection and classification of neural action potentials
Lewicki, M. S. (1998) · Network Computation in Neural Systems · doi:10.1088/0954-898x_9_4_001 · Cited by 1,372
Harris, K. D., Henze, D. A., Csicsvari, J. L., Hirase, H., & Buzsáki, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.401 · Cited by 1,153
Stimulation of neurite outgrowth using an electrically conducting polymer
Schmidt, C. E., Shastri, V. P., Vacanti, J. P., & Langer, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.8948 · Cited by 1,072
Intracellular Features Predicted by Extracellular Recordings in the Hippocampus In Vivo
Henze, D. A., Borhegyi, Z., Csicsvari, J., Mamiya, A., Harris, K. D., & Buzsáki, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.390 · Cited by 942
Biran, R., Martin, D. C., & Tresco, P. A. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.04.020 · Cited by 893
Self-citation
Research works printed but not linked: 5
- Schmidt E, 1990, Neurophysiol. Tech., 1
- Vetter R J, 2004, IEEE Trans. Neural Syst. Rehabil. Eng., 52, 896
- 10.1088/0954-898X/9/4/001 · DOI
- Kuffler S W, 1976, A Cellular Approach to the Function of the Nervous System.
- Black J, 1999, Fundamentals of Biocompatibility
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The rise of plastic bioelectronics
Someya, T., Bao, Z., & Malliaras, G. G. (2016) · Nature · doi:10.1038/nature21004 · Cited by 1,884
Conducting polymers in biomedical engineering
Guimard, N. K., Gomez, N., & Schmidt, C. E. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.012 · Cited by 1,599
An Integrated Brain-Machine Interface Platform With Thousands of Channels
Musk, E., & Neuralink (2019) · Journal of Medical Internet Research · doi:10.2196/16194 · Cited by 1,206
In vivo recordings of brain activity using organic transistors
Khodagholy, D., Doublet, T., Quilichini, P., Gurfinkel, M., Leleux, P., Ghestem, A., Ismailova, E., Hervé, T., Sanaur, S., Bernard, C., et al. (2013) · Nature Communications · doi:10.1038/ncomms2573 · Cited by 1,057
Metadata
- Authors
- Ludwig, K. A., Uram, J. D., Yang, J., Martin, D. C., & Kipke, D. R.
- Affiliations
- University of Michigan (US)
- Dow Chemical (United States) (US)
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2006-03-01
- Volume
- 3
- Issue
- 1
- Pages
- 59-70
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- OpenAlex
- W2057005089
- Cited by
- 638
- References
- 55
- Citations by year
- 2026: 15 · 2025: 24 · 2024: 24 · 2023: 22 · 2022: 23 · 2021: 37 · 2020: 34 · 2019: 39 · 2018: 52 · 2017: 57 · 2016: 42 · 2015: 51 · 2014: 38 · 2013: 32 · 2012: 24
- FWCI
- 8.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Science Foundation (9986866, 0518079, 0084304)
- University of Michigan
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (N01 NS 12338)
- Division of Materials Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
- Keywords
- PEDOT, conducting polymer coatings, chronic neural recording, electrodeposition, electrode impedance, signal-to-noise ratio, local field potentials, low-frequency drift
- MeSH terms
- Action Potentials, Animals, Electrochemistry, Electrodes, Implanted, Equipment Design, Male, Membranes, Artificial, Microelectrodes, Motor Cortex, Neurons, Polymers, Silicon, Time Factors, Rats, Sprague-Dawley, Monitoring, Ambulatory, Bridged Bicyclo Compounds, Heterocyclic, Equipment Failure Analysis, Coated Materials, Biocompatible, Rats
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