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Characterization of a biodegradable coralline hydroxyapatite/calcium carbonate composite and its clinical implementation
Open accessAbstract
A partially converted, biodegradable coralline hydroxyapatite/calcium carbonate (CHACC) composite comprising a coral calcium carbonate scaffold enveloped by a thin layer of hydroxyapatite was used in the present study. The CHACC was characterized using powder x-ray diffraction, scanning electron microscopy and energy dispersive x-ray spectroscopy. The ability of the CHACC to promote conductive osteogenesis was assessed in vitro using human mesenchymal stem cells (hMSCs) and in vivo using an immunodeficient mouse model. The clinical performance of CHACC as a bone substitute to fill voids caused by excision of bone tumours was also observed in 16 patients. The CHACC was found to consist of two overlapping layers both morphologically and chemically. Hydroxyapatite formed a thin layer of nanocrystals on the surface and a thick rough crystal layer of around 30 µm in thickness enveloping the rock-like core calcium carbonate exoskeletal architecture. hMSCs cultured on CHACC in osteogenic medium demonstrated significant osteogenic differentiation. After subcutaneous implantation of CHACC incorporating osteogenically differentiated hMSCs and an anti-resorptive agent, risedronate, into an immunodeficient mouse model, bone formation was observed on the surface of the implants. Clinical application of CHACC alone in 16 patients for bone augmentation after tumour removal showed that after implantation, visible callus formation was observed at one month and clinical bone healing achieved at four months. The majority of the implanted CHACC was degraded in 18-24 months. In conclusion, CHACC appears to be an excellent biodegradable bone graft material. It biointegrates with the host, is osteoconductive, biodegradable and can be an attractive alternative to autogenous grafts.
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In an immunodeficient mouse model, subcutaneous implantation of a biodegradable coralline hydroxyapatite-calcium carbonate composite co-cultured with MSCs led to significant osteogenesis and bone formation.
“In an immunodeficient mouse model, the subcutaneous implantation of a biodegradable coralline hydroxyapatite–calcium carbonate (CHACC) composite co-cultured with MSCs led to significant osteogenesis and bone formation [101].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [101]
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Metadata
- Authors
- Fu, K., Xu, Q., Czernuszka, J., Triffitt, J. T., & Xia, Z.
- Affiliations
- Hainan Medical College Hospital (CN)
- University of Oxford (GB)
- Swansea University (GB)
- Corresponding author
- Xia, Zhidao
- Venue
- Biomedical Materials
- Publisher
- IOP Publishing
- Published
- 2013-11-28
- Volume
- 8
- Issue
- 6
- Pages
- 065007
- ISSN
- 1748-6041 (ISSN-L)
- 1748-605X
- OpenAlex
- W2081837566
- Cited by
- 49
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 1
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biomedical Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Procter and Gamble
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- coralline hydroxyapatite, calcium carbonate, biodegradable bone substitutes, human mesenchymal stem cells, osteogenic differentiation, bone augmentation, risedronate, bone regeneration, biodegradation, osteoconduction
- MeSH terms
- Adolescent, Animals, Bone Neoplasms, Calcium Carbonate, Cell Differentiation, Ceramics, Female, Fibrous Dysplasia of Bone, Humans, Hydroxyapatites, Male, Materials Testing, Microscopy, Electron, Scanning, Osteogenesis, Spectrometry, X-Ray Emission, Osteochondroma, Osseointegration, Mice, SCID, Bone Substitutes, Absorbable Implants, Powder Diffraction, Cell Proliferation, Mice, Tissue Scaffolds, Mesenchymal Stem Cells
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