The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fabrication and characterization of bio-engineered cardiac pseudo tissues
Open accessAbstract
We report on fabricating functional three-dimensional (3D) tissue constructs using an inkjet based bio-prototyping method. With the use of modified inkjet printers, contractile cardiac hybrids that exhibit the forms of the 3D rectangular sheet and even the 'half heart' (with two connected ventricles) have been fabricated by arranging alternate layers of biocompatible alginate hydrogels and mammalian cardiac cells according to pre-designed 3D patterns. In this study, primary feline adult and H1 cardiomyocytes were used as model cardiac cells. Alginate hydrogels with controlled micro-shell structures were built by spraying cross-linkers in micro-drops onto un-gelled alginic acid. The cells remained viable in constructs as thick as 1 cm due to the programmed porosity. Microscopic and macroscopic contractile functions of these cardiomyocyte constructs were observed in vitro. These results suggest that the inkjet bio-prototyping method could be used for hierarchical design of functional cardiac pseudo tissues, balanced with porosity for mass transport and structural support.
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Claycomb, W. C., Lanson, N. A., Stallworth, B. S., Egeland, D. B., Delcarpio, J. B., Bahinski, A., & Izzo, N. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2979 · Cited by 1,546
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3D bioprinting for engineering complex tissues
Mandrycky, C., Wang, Z., Kim, K., & Kim, D.-H. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.011 · Cited by 1,754
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Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119536 · Cited by 1,156
The bioink: A comprehensive review on bioprintable materials
Hospodiuk, M., Dey, M., Sosnoski, D., & Ozbolat, I. T. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.006 · Cited by 1,118
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Moroni, L., Burdick, J. A., Highley, C., Lee, S. J., Morimoto, Y., Takeuchi, S., & Yoo, J. J. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0006-y · Cited by 753
Metadata
- Authors
- Xu, T., Baicu, C., Aho, M., Zile, M., & Boland, T.
- Venue
- Biofabrication
- Publisher
- IOP Publishing
- Published
- 2009-09-01
- Volume
- 1
- Issue
- 3
- Pages
- 035001
- ISSN
- 1758-5082 (ISSN-L)
- 1758-5090
- OpenAlex
- W1990629503
- Cited by
- 211
- References
- 1
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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