Gene Delivery Using Herpes Simplex Virus Vectors

Burton, Edward A.; Fink, David J.; Glorioso, Joseph C.

doi:10.1089/104454902762053864

Cited by 92Virus-based gene therapy researchHerpesvirus Infections and TreatmentsRNA Interference and Gene Delivery

Gene Delivery Using Herpes Simplex Virus Vectors

Burton, Edward A., Fink, David J., Glorioso, Joseph C.·2002·DNA and Cell Biology

DOI 10.1089/104454902762053864

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Abstract

Herpes simplex virus (HSV) is a neurotropic DNA virus with many favorable properties as a gene delivery vector. HSV is highly infectious, so HSV vectors are efficient vehicles for the delivery of exogenous genetic material to cells. Viral replication is readily disrupted by null mutations in immediate early genes that in vitro can be complemented in trans, enabling straightforward production of high-titre pure preparations of non-pathogenic vector. The genome is large (152 Kb) and many of the viral genes are dispensable for replication in vitro, allowing their replacement with large or multiple transgenes. Latent infection with wild-type virus results in episomal viral persistence in sensory neuronal nuclei for the duration of the host lifetime. Transduction with replication-defective vectors causes a latent-like infection in both neural and non-neural tissue; the vectors are non-pathogenic, unable to reactivate and persist long-term. The latency active promoter complex can be exploited in vector design to achieve long-term stable transgene expression in the nervous system. HSV vectors transduce a broad range of tissues because of the wide expression pattern of the cellular receptors recognized by the virus. Increasing understanding of the processes involved in cellular entry has allowed preliminary steps to be taken towards targeting the tropism of HSV vectors. Using replication-defective HSV vectors, highly encouraging results have emerged from recent pre-clinical studies on models of neurological disease, including glioma, peripheral neuropathy, chronic pain and neurodegeneration. Consequently, HSV vectors encoding appropriate transgenes to tackle these pathogenic processes are poised to enter clinical trials.

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Currently, gene delivery and gene therapy applications use 3 types of HSV vectors.
“Currently, gene delivery and gene therapy applications use 3 types of HSV vectors.”
From Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges (2020) · cites this paper as [111]

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903 · see citing works
Dystrophin: the protein product of the Duchenne muscular dystrophy locus
Hoffman, E. P., Brown, R. H., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90579-4 · Cited by 4,693 · see citing works
Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals
Koenig, M., Hoffman, E. P., Bertelson, C. J., Monaco, A. P., Feener, C., & Kunkel, L. M. (1987) · Cell · doi:10.1016/0092-8674(87)90504-6 · Cited by 2,411 · see citing works
Dystrophin expression in the mdx mouse restored by stem cell transplantation
Gussoni, E., Soneoka, Y., Strickland, C. D., Buzney, E. A., Khan, M. K., Flint, A., Kunkel, L. M., & Mulligan, R. C. (1999) · Nature · doi:10.1038/43919 · Cited by 1,800 · see citing works
The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
McGeoch, D. J., Dalrymple, M. A., Davison, A. J., Dolan, A., Frame, M. C., McNab, D., Perry, L. J., Scott, J. E., & Taylor, P. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-7-1531 · Cited by 1,618 · see citing works
Regulation of Herpesvirus Macromolecular Synthesis I. Cascade Regulation of the Synthesis of Three Groups of Viral Proteins
Honess, R. W., & Roizman, B. (1974) · Journal of Virology · doi:10.1128/jvi.14.1.8-19.1974 · Cited by 1,415 · see citing works
Herpes Simplex Viruses
Whitley, R. J., Kimberlin, D. W., & Roizman, B. (1998) · Clinical Infectious Diseases · doi:10.1086/514600 · Cited by 1,151 · see citing works
Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family
Montgomery, R. I., Warner, M. S., Lum, B. J., & Spear, P. G. (1996) · Cell · doi:10.1016/s0092-8674(00)81363-x · Cited by 1,099 · see citing works
Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant
Martuza, R. L., Malick, A., Markert, J. M., et al. (1991) · Science · doi:10.1126/science.1851332 · Cited by 1,058 · see citing works
Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial
Markert, J. M., Medlock, M. D., Rabkin, S. D., Gillespie, G. Y., Todo, T., Hunter, W. D. G., Palmer, C. A., Feigenbaum, F., Tornatore, C., Tufaro, F., et al. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301205 · Cited by 976 · see citing works
Initial interaction of herpes simplex virus with cells is binding to heparan sulfate
WuDunn, D., & Spear, P. G. (1989) · Journal of Virology · doi:10.1128/jvi.63.1.52-58.1989 · Cited by 920 · see citing works
Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor
Geraghty, R. J., Krummenacher, C., Cohen, G. H., Eisenberg, R. J., & Spear, P. G. (1998) · Science · doi:10.1126/science.280.5369.1618 · Cited by 907 · see citing works
RNA Complementary to a Herpesvirus α Gene mRNA Is Prominent in Latently Infected Neurons
Stevens, J. G., Wagner, E. K., Devi-Rao, G. B., et al. (1987) · Science · doi:10.1126/science.2434993 · Cited by 901 · see citing works
Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas
Mineta, T., Rabkin, S. D., Yazaki, T., Hunter, W. D. G., & Martuza, R. L. (1995) · Nature Medicine · doi:10.1038/nm0995-938 · Cited by 823 · see citing works
Herpes simplex virus turns off the TAP to evade host immunity
Hill, A. B., Jugovic, P., York, L., Russ, G., Bennink, J., Yewdell, J. W., Ploegh, H. L., & Johnson, D. C. (1995) · Nature · doi:10.1038/375411a0 · Cited by 802 · see citing works
Herpes simplex virus turns off the TAP to evade host immunity
(1995) · Trends in Genetics · doi:10.1016/0168-9525(95)90181-7 · Cited by 736 · see citing works
Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4
DeLuca, N. A., McCarthy, A. M., & Schaffer, P. A. (1985) · Journal of Virology · doi:10.1128/jvi.56.2.558-570.1985 · Cited by 710 · see citing works
Primary structure of the human Met- and Leu-enkephalin precursor and its mRNA
Comb, M. J., Seeburg, P. H., Adelman, J. P., Eiden, L. E., & Herbert, E. (1982) · Nature · doi:10.1038/295663a0 · Cited by 679 · see citing works
A viral inhibitor of peptide transporters for antigen presentation
Früh, K., Ahn, K., Djaballah, H., Sempé, P., Endert, P. V., Tampé, R., Peterson, P. A., & Yang, Y. M. (1995) · Nature · doi:10.1038/375415a0 · Cited by 601 · see citing works
Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma
Rampling, R. P., Cruickshank, G., Papanastassiou, V., Nicoll, J. A. R., Hadley, D. M., Brennan, D., Petty, R., MacLean, A. G., Harland, J., McKie, E. A., et al. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301184 · Cited by 594 · see citing works
Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.
Honess, R. W., & Roizman, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.4.1276 · Cited by 586 · see citing works
Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription
Campbell, M. E. M., Palfreyman, J. W., & Preston, C. M. (1984) · Journal of Molecular Biology · doi:10.1016/0022-2836(84)90427-3 · Cited by 574 · see citing works
Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity
Herold, B. C., WuDunn, D., Soltys, N., & Spear, P. G. (1991) · Journal of Virology · doi:10.1128/jvi.65.3.1090-1098.1991 · Cited by 571 · see citing works
A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes
York, I. A., Roop, C., Andrews, D. W., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90215-1 · Cited by 565 · see citing works
Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans.
Shieh, M. T., WuDunn, D., Montgomery, R. I., Esko, J. D., & Spear, P. G. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.5.1273 · Cited by 545 · see citing works
Structural biology of viruses
Chiu, W. K., Burnett, R. M., & Garcea, R. L. (1997) · Oxford University Press eBooks · Cited by 532 · see citing works
Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1
McGeoch, D. J., Dolan, A., Donald, S., & Rixon, F. J. (1985) · Journal of Molecular Biology · doi:10.1016/0022-2836(85)90320-1 · Cited by 521 · see citing works
The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector
Spaete, R. R. (1982) · Cell · doi:10.1016/0092-8674(82)90035-6 · Cited by 511 · see citing works
A herpes simplex virus mutant in which glycoprotein D sequences are replaced by beta-galactosidase sequences binds to but is unable to penetrate into cells
Ligas, M. W., & Johnson, D. C. (1988) · Journal of Virology · doi:10.1128/jvi.62.5.1486-1494.1988 · Cited by 510 · see citing works
The proteins specified by herpes simplex virus
Spear, P. G., & Roizman, B. (1968) · Virology · doi:10.1016/0042-6822(68)90186-4 · Cited by 479 · see citing works
Herpes simplex virus
Widener, R. W., & Whitley, R. J. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53488-0.00011-0 · Cited by 479 · see citing works
Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion
Cai, W., Gu, B., & Person, S. (1988) · Journal of Virology · doi:10.1128/jvi.62.8.2596-2604.1988 · Cited by 476 · see citing works
Virus-Induced Neuronal Apoptosis Blocked by the Herpes Simplex Virus Latency-Associated Transcript
Perng, G., Jones, C., Zanella, J. R. C., et al. (2000) · Science · doi:10.1126/science.287.5457.1500 · Cited by 472 · see citing works
Development of Approaches to Improve Cell Survival in Myoblast Transfer Therapy
Qu, Z., Balkir, L., van Deutekom, J. C. T., Robbins, P. D., Pruchnic, R., & Huard, J. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.5.1257 · Cited by 456 · see citing works
Pathogenesis of Herpetic Neuritis and Ganglionitis in Mice: Evidence for Intra-Axonal Transport of Infection
Cook, M. L., & Stevens, J. G. (1973) · Infection and Immunity · doi:10.1128/iai.7.2.272-288.1973 · Cited by 454 · see citing works
Herpes simplex virus type 1 ICP27 is an essential regulatory protein
Sacks, W. R., Greene, C. C., Aschman, D. P., & Schaffer, P. A. (1985) · Journal of Virology · doi:10.1128/jvi.55.3.796-805.1985 · Cited by 425 · see citing works
Connexins and gap junctions of astrocytes and oligodendrocytes in the CNS
Nagy, J. I., & Rash, J. E. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00066-1 · Cited by 424 · see citing works
Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes
Batterson, W., & Roizman, B. (1983) · Journal of Virology · doi:10.1128/jvi.46.2.371-377.1983 · Cited by 423 · see citing works
Isolation and Characterization of a Herpes Simplex Virus Type 1 Mutant Containing a Deletion within the Gene Encoding the Immediate Early Polypeptide Vmw110
Stow, N. D., & Stow, E. C. (1986) · Journal of General Virology · doi:10.1099/0022-1317-67-12-2571 · Cited by 418 · see citing works
A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons
Geller, A. I., & Breakefield, X. O. (1988) · Science · doi:10.1126/science.2843986 · Cited by 412 · see citing works
Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted
Forrester, A., Farrell, H. E., Wilkinson, G. W. G., Kaye, J. F., Davis-Poynter, N. J., & Minson, T. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.341-348.1992 · Cited by 389 · see citing works
Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins
Samaniego, L. A., Neiderhiser, L., & DeLuca, N. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.3307-3320.1998 · Cited by 373 · see citing works
Entry of alphaherpesviruses into cells
Spear, P. G. (1993) · Seminars in Virology · doi:10.1006/smvy.1993.1012 · Cited by 373 · see citing works
Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1
Rock, D. L., Nesburn, A. B., Ghiasi, H., et al. (1987) · Journal of Virology · doi:10.1128/jvi.61.12.3820-3826.1987 · Cited by 356 · see citing works
Herpes simplex virus virion host shutoff function
Kwong, A. D., Kruper, J. A., & Frenkeĺ, N. (1988) · Journal of Virology · doi:10.1128/jvi.62.3.912-921.1988 · Cited by 345 · see citing works
Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B
Herold, B. C., Visalli, R. J., Susmarski, N., Brandt, C. R., & Spear, P. G. (1994) · Journal of General Virology · doi:10.1099/0022-1317-75-6-1211 · Cited by 338 · see citing works
Membrane proteins specified by herpes simplex viruses. III. Role of glycoprotein VP7(B2) in virion infectivity
Sarmiento, M., Haffey, M. L., & Spear, P. G. (1979) · Journal of Virology · doi:10.1128/jvi.29.3.1149-1158.1979 · Cited by 336 · see citing works
Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1
McGeoch, D. J., Dolan, A., Donald, S., & Brauer, D. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.4.1727 · Cited by 332 · see citing works
Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient
McCarthy, A. M., McMahan, L., & Schaffer, P. A. (1989) · Journal of Virology · doi:10.1128/jvi.63.1.18-27.1989 · Cited by 330 · see citing works
Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture
Sacks, W. R., & Schaffer, P. A. (1987) · Journal of Virology · doi:10.1128/jvi.61.3.829-839.1987 · Cited by 329 · see citing works
A novel herpes simplex virus glycoprotein, gL, forms a complex with glycoprotein H (gH) and affects normal folding and surface expression of gH
Hutchinson, L., Browne, H. M., Wargent, V., Davis-Poynter, N. J., Primorac, S., Goldsmith, K., Minson, A. C., & Johnson, D. C. (1992) · Journal of Virology · doi:10.1128/jvi.66.4.2240-2250.1992 · Cited by 328 · see citing works
Latent Herpes Simplex Virus in Human Trigeminal Ganglia
Croen, K. D., Ostrove, J. M., Dragovic, L. J., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198712033172302 · Cited by 320 · see citing works
A mutant herpes simplex virus type 1 unable to express glycoprotein L cannot enter cells, and its particles lack glycoprotein H
Roop, C., Hutchinson, L., & Johnson, D. C. (1993) · Journal of Virology · doi:10.1128/jvi.67.4.2285-2297.1993 · Cited by 315 · see citing works
During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure
Deshmane, S. L., & Fraser, N. (1989) · Journal of Virology · doi:10.1128/jvi.63.2.943-947.1989 · Cited by 309 · see citing works
Pre- and postsynaptic distribution of μ, δ and κ opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord
Besse, D., Lombard, M. C., Zajac, J., Roques, B. P., & Besson, J. (1990) · Brain Research · doi:10.1016/0006-8993(90)91519-m · Cited by 306 · see citing works
Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus
Emi, N., Friedmann, T., & Yee, J. K. (1991) · Journal of Virology · doi:10.1128/jvi.65.3.1202-1207.1991 · Cited by 302 · see citing works
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes
Mackem, S., & Roizman, B. (1982) · Journal of Virology · doi:10.1128/jvi.44.3.939-949.1982 · Cited by 298 · see citing works
Detection of herpes simplex virus type 1 transcripts during latent infection in mice
Spivack, J. G., & Fraser, N. (1987) · Journal of Virology · doi:10.1128/jvi.61.12.3841-3847.1987 · Cited by 296 · see citing works
Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry
Whitbeck, J. C., Peng, C., Lou, H., Xu, R., Willis, S. H., de Leon, M. P., Peng, T., Nicola, A. V., Montgomery, R. I., Warner, M. S., et al. (1997) · Journal of Virology · doi:10.1128/jvi.71.8.6083-6093.1997 · Cited by 291 · see citing works
Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides
Read, G. S., & Frenkeĺ, N. (1983) · Journal of Virology · doi:10.1128/jvi.46.2.498-512.1983 · Cited by 290 · see citing works
Heparan Sulfate Proteoglycan Binding by Herpes Simplex Virus Type 1 Glycoproteins B and C, Which Differ in Their Contributions to Virus Attachment, Penetration, and Cell-to-Cell Spread
Laquerre, S. G., Argnani, R., Anderson, D. B., Zucchini, S., Manservigi, R., & Glorioso, J. C. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.6119-6130.1998 · Cited by 289 · see citing works
Self-citation
Herpes simplex virus latency-associated transcript is a stable intron.
Farrell, M. J., Dobson, A. T., & Feldman, L. T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.790 · Cited by 288 · see citing works
Herpes simplex virus-infected cells contain a function(s) that destabilizes both host and viral mRNAs.
Kwong, A. D., & Frenkeĺ, N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.7.1926 · Cited by 285 · see citing works
The Ectodomain of a Novel Member of the Immunoglobulin Subfamily Related to the Poliovirus Receptor Has the Attributes of a Bona Fide Receptor for Herpes Simplex Virus Types 1 and 2 in Human Cells
Cocchi, F., Menotti, L., Mirandola, P., et al. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9992-10002.1998 · Cited by 281 · see citing works
Helper virus-free transfer of herpes simplex virus type 1 plasmid vectors into neural cells
Fraefel, C., Song, S., Lim, F., et al. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.7190-7197.1996 · Cited by 272 · see citing works
The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency
Perng, G., Dunkel, E. C., Geary, P. A., et al. (1994) · Journal of Virology · doi:10.1128/jvi.68.12.8045-8055.1994 · Cited by 261 · see citing works
Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells
Cai, W., & Schaffer, P. A. (1992) · Journal of Virology · doi:10.1128/jvi.66.5.2904-2915.1992 · Cited by 259 · see citing works
Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence
MacLean, A. R., Ul-Fareed, M., Robertson, L., et al. (1991) · Journal of General Virology · doi:10.1099/0022-1317-72-3-631 · Cited by 254 · see citing works
Cell fusion induced by herpes simplex virus is promoted and suppressed by different viral glycoproteins.
Manservigi, R., Spear, P. G., & BUCHAN, A. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.9.3913 · Cited by 250 · see citing works
Deletion of multiple immediate–early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons
Krisky, D., Wolfe, D. P., Goins, W., et al. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300766 · Cited by 249 · see citing works
Anti-glycoprotein D antibodies that permit adsorption but block infection by herpes simplex virus 1 prevent virion-cell fusion at the cell surface.
Fuller, A. O., & Spear, P. G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5454 · Cited by 246 · see citing works
Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells.
Pfizenmaier, K., Scheurich, P., Schlüter, C., & Krönke, M. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.3.975 · Cited by 245 · see citing works
Herpes simplex virus type 1 latency‐associated transcripts are evidently not essential for latent infection.
Steiner, I., Spivack, J. G., Lirette, R. P., et al. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03404.x · Cited by 245 · see citing works
Neutralizing monoclonal antibodies specific for herpes simplex virus glycoprotein D inhibit virus penetration
Highlander, S. L., Sutherland, S., Gage, P. J., Johnson, D. C., Levine, M., & Glorioso, J. C. (1987) · Journal of Virology · doi:10.1128/jvi.61.11.3356-3364.1987 · Cited by 237 · see citing works
Self-citation
Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus
Dobson, A. T., Sederati, F., Devi-Rao, G. B., et al. (1989) · Journal of Virology · doi:10.1128/jvi.63.9.3844-3851.1989 · Cited by 224 · see citing works
Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus
Wilson, S. P., Yeomans, D. C., Bender, M. A., Lu, Y. C., Goins, W. F., & Glorioso, J. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3211 · Cited by 216 · see citing works
Self-citation
The properties and sequence of glycoprotein H of herpes simplex virus type 1
Gompels, U. A., & Minson, A. C. (1986) · Virology · doi:10.1016/0042-6822(86)90026-7 · Cited by 214 · see citing works
Physical state of the latent herpes simplex virus genome in a mouse model system: Evidence suggesting an episomal state
Mellerick, D. M., & Fraser, N. W. (1987) · Virology · doi:10.1016/0042-6822(87)90198-x · Cited by 210 · see citing works
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency
Thompson, R., & Sawtell, N. M. (1997) · Journal of Virology · doi:10.1128/jvi.71.7.5432-5440.1997 · Cited by 207 · see citing works
Herpesvirus vector gene transfer and expression of β–glucuronidase in the central nervous system of MRS VII mice
Wolfe, J. H. N., Deshmane, S. L., & Fraser, N. W. (1992) · Nature Genetics · doi:10.1038/ng0892-379 · Cited by 204 · see citing works
Entry of herpes simplex virus 1 in BJ cells that constitutively express viral glycoprotein D is by endocytosis and results in degradation of the virus
Campadelli‐Fiume, G., Arsenakis, M., Farabegoli, F., & Roizman, B. (1988) · Journal of Virology · doi:10.1128/jvi.62.1.159-167.1988 · Cited by 200 · see citing works
Neutralizing antibodies specific for glycoprotein H of herpes simplex virus permit viral attachment to cells but prevent penetration
Fuller, A. O., Santos, R. E., & Spear, P. G. (1989) · Journal of Virology · doi:10.1128/jvi.63.8.3435-3443.1989 · Cited by 200 · see citing works
Stem cell therapy and gene transfer for regeneration
Asahara, T., Kalka, C., & Isner, J. M. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301142 · Cited by 196 · see citing works
A herpes simplex virus transcript abundant in latently infected neurons is dispensable for for establishment of the latent state
Javier, R. T., Stevens, J. G., Dissette, V. B., et al. (1988) · Virology · doi:10.1016/0042-6822(88)90169-9 · Cited by 196 · see citing works
Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord
Kohno, T., Kumamoto, E., Higashi, H., Shimoji, K., & Yoshimura, M. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0803p.x · Cited by 196 · see citing works
Electron Microscopy of Herpes Simplex Virus
Rose, H. M., & Mednis, B. (1968) · Journal of Virology · doi:10.1128/jvi.2.5.507-516.1968 · Cited by 195 · see citing works
Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma.
Chambers, R., Gillespie, G. Y., Soroceanu, L., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1411 · Cited by 193 · see citing works
The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27
Samaniego, L. A., Wu, N., & DeLuca, N. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.6.4614-4625.1997 · Cited by 191 · see citing works
Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.
Whitley, R. J., Kern, E. R., Chatterjee, S., et al. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116527 · Cited by 188 · see citing works
An Enhanced Packaging System for Helper-Dependent Herpes Simplex Virus Vectors
Stavropoulos, T. A., & Strathdee, C. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.9.7137-7143.1998 · Cited by 187 · see citing works
Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript
Zwaagstra, J. C., Ghiasi, H., Slanina, S. M., et al. (1990) · Journal of Virology · doi:10.1128/jvi.64.10.5019-5028.1990 · Cited by 186 · see citing works
Nucleotide sequence of a region of the herpes simplex virus type 1 gB glycoprotein gene: Mutations affecting rate of virus entry and cell fusion
Bzik, D. J., Fox, B. A., DeLuca, N. A., & Person, S. (1984) · Virology · doi:10.1016/0042-6822(84)90022-9 · Cited by 186 · see citing works
Excretion of Non-infectious Virus Particles Lacking Glycoprotein H by a Temperature-sensitive Mutant of Herpes Simplex Virus Type 1: Evidence that gH Is Essential for Virion Infectivity
Desai, P. J., Schaffer, P. A., & Minson, A. C. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-6-1147 · Cited by 185 · see citing works
Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo.
Dilber, M. S., Abedi, M. R., Christensson, B., et al. (1997) · PubMed · Cited by 184 · see citing works
A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1
Garber, D. A., Schaffer, P. A., & Knipe, D. M. (1997) · Journal of Virology · doi:10.1128/jvi.71.8.5885-5893.1997 · Cited by 182 · see citing works
Herpes simplex viruses lacking glycoprotein D are unable to inhibit virus penetration: quantitative evidence for virus-specific cell surface receptors
Johnson, D. C., & Ligas, M. W. (1988) · Journal of Virology · doi:10.1128/jvi.62.12.4605-4612.1988 · Cited by 181 · see citing works
Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir
Markert, J. M., Malick, A., Coen, D. M., et al. (1993) · Neurosurgery · doi:10.1227/00006123-199304000-00016 · Cited by 179 · see citing works
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus
Chen, S. H., Kramer, M. F., Schaffer, P. A., et al. (1997) · Journal of Virology · doi:10.1128/jvi.71.8.5878-5884.1997 · Cited by 178 · see citing works
A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats
Goins, W. F., Sternberg, L. R., Croen, K. D., et al. (1994) · Journal of Virology · doi:10.1128/jvi.68.4.2239-2252.1994 · Cited by 177 · see citing works
Heparan Sulfate Glycosaminoglycans as Primary Cell Surface Receptors for Herpes Simplex Virus
Spear, P. G., Shieh, M.-T., Herold, B. C., WuDunn, D., & Koshy, T. I. (1992) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2444-5_33 · Cited by 176 · see citing works
Soluble forms of herpes simplex virus glycoprotein D bind to a limited number of cell surface receptors and inhibit virus entry into cells
Johnson, D. C., Burke, R. L., & Gregory, T. J. (1990) · Journal of Virology · doi:10.1128/jvi.64.6.2569-2576.1990 · Cited by 175 · see citing works
Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22
Wu, N., Watkins, S. C., Schaffer, P. A., & DeLuca, N. A. (1996) · Journal of Virology · doi:10.1128/jvi.70.9.6358-6369.1996 · Cited by 173 · see citing works
Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion
Goss, J. R., Mata, M. M., Goins, W. F., et al. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301430 · Cited by 170 · see citing works
The DNA Sequences of the Long Repeat Region and Adjoining Parts of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
Perry, L. J., & McGeoch, D. J. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-11-2831 · Cited by 169 · see citing works
Replication-defective herpes simplex virus vectors for gene transfer in vivo.
Marconi, P., Krisky, D. M., Oligino, T., Poliani, P. L., Ramakrishnan, R., Goins, W. F., Fink, D. J., & Glorioso, J. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11319 · Cited by 168 · see citing works
Self-citation
Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse.
Ho, D. Y., & Mocarski, E. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7596 · Cited by 165 · see citing works
Nucleotide sequences of herpes simplex virus type 1 (HSV-1) affecting virus entry, cell fusion, and production of glycoprotein gB (VP7)
DeLuca, N. A., Bzik, D. J., Bond, V. C., Person, S., & Snipes, W. (1982) · Virology · doi:10.1016/0042-6822(82)90240-9 · Cited by 156 · see citing works
Herpes simplex virus infection and propagation in a mouse L cell mutant lacking heparan sulfate proteoglycans
Gruenheid, S., Gatzke, L., Meadows, H., et al. (1993) · Journal of Virology · doi:10.1128/jvi.67.1.93-100.1993 · Cited by 153 · see citing works
Development of herpes simplex virus replication-defective multigene vectors for combination gene therapy applications
Krisky, D., Marconi, P., Oligino, T., et al. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300755 · Cited by 153 · see citing works
Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord
Glaum, S., Miller, R., & Hammond, D. L. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04965.1994 · Cited by 152 · see citing works
Viral DNA synthesis is required for the efficient expression of specific herpes simplex virus type 1 mRNA species
Holland, L. E., Anderson, K., Shipman, C., et al. (1980) · Virology · doi:10.1016/0042-6822(80)90479-1 · Cited by 151 · see citing works
The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript
Perng, G., Ghiasi, H., Slanina, S. M., et al. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.976-984.1996 · Cited by 151 · see citing works
Retrograde axonal transport of herpes simplex virus: Evidence for a single mechanism and a role for tegument
Bearer, E. L., Breakefield, X. O., Schuback, D. E., Reese, T. S., & LaVail, J. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.8146 · Cited by 150 · see citing works
Arrangement of Herpesvirus Deoxyribonucleic Acid in the Core
Furlong, D., Swift, H. H., & Roizman, B. (1972) · Journal of Virology · doi:10.1128/jvi.10.5.1071-1074.1972 · Cited by 150 · see citing works
Evaluation of genetically engineered herpes simplex viruses as oncolytic agents for human malignant brain tumors.
Andreansky, S. S., Soroceanu, L., Er, F., et al. (1997) · PubMed · Cited by 147 · see citing works
The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency.
Leib, D. A., Nadeau, K. C., Rundle, S. A., & Schaffer, P. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.1.48 · Cited by 144 · see citing works
Specificities of monoclonal and polyclonal antibodies that inhibit adsorption of herpes simplex virus to cells and lack of inhibition by potent neutralizing antibodies
Fuller, A. O., & Spear, P. G. (1985) · Journal of Virology · doi:10.1128/jvi.55.2.475-482.1985 · Cited by 140 · see citing works
Gap junctions: the “kiss of death” and the “kiss of life”
Andrade-Rozental, A. F., Rozental, R., Hopperstad, M. G., et al. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00099-5 · Cited by 138 · see citing works
The herpes simplex virus virion host shutoff function
Kwong, A. D., & Frenkeĺ, N. (1989) · Journal of Virology · doi:10.1128/jvi.63.11.4834-4839.1989 · Cited by 136 · see citing works
Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4
Samaniego, L. A., Webb, A. L., & DeLuca, N. A. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5705-5715.1995 · Cited by 134 · see citing works
Monoclonal Antibodies to Distinct Sites on Herpes Simplex Virus (HSV) Glycoprotein D Block HSV Binding to HVEM
Nicola, A. V., de Leon, M. P., Xu, R., Hou, W., Whitbeck, J. C., Krummenacher, C., Montgomery, R. I., Spear, P. G., Eisenberg, R. J., & Cohen, G. H. (1998) · Journal of Virology · doi:10.1128/jvi.72.5.3595-3601.1998 · Cited by 134 · see citing works
RNA virus fitness
Domingo, E., Menéndez‐Arias, L., & Holland, J. J. (1997) · Reviews in Medical Virology · doi:10.1002/(sici)1099-1654(199707)7:2 · Cited by 133 · see citing works
Assembly of the Herpes Simplex Virus Procapsid from Purified Components and Identification of Small Complexes Containing the Major Capsid and Scaffolding Proteins
Newcomb, W. W., Homa, F. L., Thomsen, D. R., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.5.4239-4250.1999 · Cited by 130 · see citing works
The First Immunoglobulin-Like Domain of HveC Is Sufficient To Bind Herpes Simplex Virus gD with Full Affinity, While the Third Domain Is Involved in Oligomerization of HveC
Krummenacher, C., Rux, A. H., Whitbeck, J. C., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8127-8137.1999 · Cited by 129 · see citing works
Immunoglobulin G(Fc)-binding receptors on virions of herpes simplex virus type 1 and transfer of these receptors to the cell surface by infection
Para, M. F., Baucke, R. B., & Spear, P. G. (1980) · Journal of Virology · doi:10.1128/jvi.34.2.512-520.1980 · Cited by 128 · see citing works
Anterograde Transport of Herpes Simplex Virus Type 1 in Cultured, Dissociated Human and Rat Dorsal Root Ganglion Neurons
Saksena, M. M., Armati, P. J., Boadle, R. A., Holland, D. J., & Cunningham, A. L. (2000) · Journal of Virology · doi:10.1128/jvi.74.4.1827-1839.2000 · Cited by 128 · see citing works
Development and Optimization of Herpes Simplex Virus Vectors for Multiple Long-Term Gene Delivery to the Peripheral Nervous System
Palmer, J. A., Branston, R. H., Lilley, C. E., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.12.5604-5618.2000 · Cited by 124 · see citing works
Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function
Johnson, P. A., Wang, M. J., & Friedmann, T. (1994) · Journal of Virology · doi:10.1128/jvi.68.10.6347-6362.1994 · Cited by 123 · see citing works
Monoclonal antibodies define a domain on herpes simplex virus glycoprotein B involved in virus penetration
Highlander, S. L., Cai, W., Person, S., et al. (1988) · Journal of Virology · doi:10.1128/jvi.62.6.1881-1888.1988 · Cited by 118 · see citing works
Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.
Ej, B., Jm, S., Chase, M. R., et al. (1994) · PubMed · Cited by 116 · see citing works
Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression
Chen, J., & Silverstein, S. J. (1992) · Journal of Virology · doi:10.1128/jvi.66.5.2916-2927.1992 · Cited by 114 · see citing works
Tumor necrosis factor alpha: a multifaceted peptide hormone.
Rosenblum, M. G., & Donato, N. J. (1989) · PubMed · Cited by 114 · see citing works
Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis
Oligino, T., Ghivizzani, S. C., Wolfe, D. P., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3301014 · Cited by 110 · see citing works
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
Perng, G., Slanina, S. M., Yukht, A., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.4.1885-1891.2000 · Cited by 109 · see citing works
Herpes simplex virus vector-mediated expression of Bcl-2 prevents 6-hydroxydopamine-induced degeneration of neurons in the substantia nigra in vivo
Yamada, M., Oligino, T., Mata, M. M., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4078 · Cited by 109 · see citing works
Herpes Simplex Virus Type 1 Latency-Associated Transcripts Suppress Viral Replication and Reduce Immediate-Early Gene mRNA Levels in a Neuronal Cell Line
Mador, N., Goldenberg, D., Cohen, O. J., et al. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.5067-5075.1998 · Cited by 108 · see citing works
Herpes simplex virus type 1 latency-associated transcription plays no role in establishment or maintenance of a latent infection in murine sensory neurons
Sedarati, F., Izumi, K. M., Wagner, E. K., et al. (1989) · Journal of Virology · doi:10.1128/jvi.63.10.4455-4458.1989 · Cited by 107 · see citing works
Allele replacement: an application that permits rapid manipulation of herpes simplex virus type 1 genomes
Horsburgh, B. C., Hubinette, M., Qiang, D., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300887 · Cited by 106 · see citing works
Protein and messenger RNA expression of connexin43 in astrocytomas: implications in brain tumor gene therapy
Shinoura, N., Chen, L., Wani, M. A., Kim, Y. G., Larson, J. J., Warnick, R. E., Simon, M., Menon, A. G., Bi, W., & Stambrook, P. J. (1996) · Journal of neurosurgery · doi:10.3171/jns.1996.84.5.0839 · Cited by 104 · see citing works
Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections
Chen, X., Schmidt, M. C., Goins, W. F., et al. (1995) · Journal of Virology · doi:10.1128/jvi.69.12.7899-7908.1995 · Cited by 100 · see citing works
RNA complementary to herpes simplex virus type 1 ICP0 gene demonstrated in neurons of human trigeminal ganglia
Gordon, Y. J., Johnson, B., Romanowski, E. G., et al. (1988) · Journal of Virology · doi:10.1128/jvi.62.5.1832-1835.1988 · Cited by 97 · see citing works
Rapid method for construction of recombinant HSV gene transfer vectors
Krisky, D., Marconi, P., Oligino, T., et al. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300497 · Cited by 97 · see citing works
Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system
Lachmann, R., & Efstathiou, S. (1997) · Journal of Virology · doi:10.1128/jvi.71.4.3197-3207.1997 · Cited by 97 · see citing works
Kiss of Death
Graham, B. B., Kaul, D. R., Saint, S. K., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmcps0806935 · Cited by 96 · see citing works
Herpes Simplex Virus Type 1 Vector-Mediated Expression of Nerve Growth Factor Protects Dorsal Root Ganglion Neurons from Peroxide Toxicity
Goins, W. F., Lee, K. A., Cavalcoli, J. D., O’Malley, M. E., DeKosky, S. T., Fink, D. J., & Glorioso, J. C. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.519-532.1999 · Cited by 95 · see citing works
Self-citation
HERPES SIMPLEX VIRUS MEDIATED NERVE GROWTH FACTOR EXPRESSION IN BLADDER AND AFFERENT NEURONS: POTENTIAL TREATMENT FOR DIABETIC BLADDER DYSFUNCTION
Goins, W. F., Yoshimura, N., Phelan, M. W., Yokoyama, T., Fraser, M. O., Ozawa, H., Bennett, N., de Groat, W. C., Glorioso, J. C., & Chancellor, M. B. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)66407-5 · Cited by 95 · see citing works
Self-citation
Long-term promoter activity during herpes simplex virus latency
Lokensgard, J. R., Bloom, D. C., Dobson, A. T., et al. (1994) · Journal of Virology · doi:10.1128/jvi.68.11.7148-7158.1994 · Cited by 95 · see citing works
Effective Treatment of Experimental Glioblastoma by HSV Vector-Mediated TNFα and HSV-tk Gene Transfer in Combination with Radiosurgery and Ganciclovir Administration
Niranjan, A., Moriuchi, S., Lunsford, L. D., et al. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0101 · Cited by 95 · see citing works
An HSV LAT Null Mutant Reactivates Slowly from Latent Infection and Makes Small Plaques on CV-1 Monolayers
Block, T. M., Deshmane, S. L., Masonis, J. L., et al. (1993) · Virology · doi:10.1006/viro.1993.1078 · Cited by 91 · see citing works
Evidence for an Interaction of Herpes Simplex Virus with Chondroitin Sulfate Proteoglycans during Infection
Banfield, B. W., Leduc, Y., Esford, L. E., Visalli, R. J., Brandt, C. R., & Tufaro, F. (1995) · Virology · doi:10.1006/viro.1995.1184 · Cited by 91 · see citing works
Domains of herpes simplex virus I glycoprotein B that function in virus penetration, cell-to-cell spread, and cell fusion
Navarro, D., PAZ, P. E., & Pereira, L. (1992) · Virology · doi:10.1016/0042-6822(92)90064-v · Cited by 90 · see citing works
Complete regression of established murine hepatocellular carcinoma by in vivo tumor necrosis factor alpha gene transfer
Cao, G., Kuriyama, S., Du, P., et al. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9024304 · Cited by 86 · see citing works
Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis
Jordan, R., & Schaffer, P. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6850-6862.1997 · Cited by 85 · see citing works
Central Nervous System Delivery of Interleukin 4 by a Nonreplicative Herpes Simplex Type 1 Viral Vector Ameliorates Autoimmune Demyelination
Furlan, R., Poliani, P. L., Galbiati, F., Bergami, A., Grimaldi, L. M. E., Comı, G., Adorini, L., & Martino, G. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.17-2605 · Cited by 85 · see citing works
Intraaxonal transport of Herpes simplex virus in the rat central nervous system
Bak, I. J., Markham, C. H., Cook, M. L., et al. (1977) · Brain Research · doi:10.1016/0006-8993(77)90067-1 · Cited by 85 · see citing works
Connexin 43-Enhanced Suicide Gene Therapy Using Herpesviral Vectors
Marconi, P., Tamura, M., Moriuchi, S., et al. (2000) · Molecular Therapy · doi:10.1006/mthe.1999.0008 · Cited by 84 · see citing works
Identification of a major regulatory sequence in the latency associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV-1)
Zwaagstra, J. C., Ghiasi, H., Nesburn, A. B., et al. (1991) · Virology · doi:10.1016/0042-6822(91)90672-x · Cited by 84 · see citing works
The basal lamina is a physical barrier to herpes simplex virus-mediated gene delivery to mature muscle fibers
Huard, J., Feero, W. G., Watkins, S. C., Hoffman, E. P., Rosenblatt, D. J., & Glorioso, J. C. (1996) · Journal of Virology · doi:10.1128/jvi.70.11.8117-8123.1996 · Cited by 83 · see citing works
Self-citation
Bcl-2 and GDNF Delivered by HSV-Mediated Gene Transfer Act Additively to Protect Dopaminergic Neurons from 6-OHDA-Induced Degeneration
Natsume, A., Mata, M. M., Goss, J. R., Huang, S., Wolfe, D. P., Oligino, T., Glorioso, J. C., & Fink, D. J. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7671 · Cited by 82 · see citing works
Self-citation
Recombinant Herpes Simplex Virus Type 1 Engineered for Targeted Binding to Erythropoietin Receptor-Bearing Cells
Laquerre, S. G., Anderson, D. B., Stolz, D. B., & Glorioso, J. C. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9683-9697.1998 · Cited by 82 · see citing works
Self-citation
In vivo gene therapy for pyridoxine‐induced neuropathy by herpes simplex virus‐mediated gene transfer of neurotrophin‐3
Chattopadhyay, M., Wolfe, D. P., Huang, S., et al. (2001) · Annals of Neurology · doi:10.1002/ana.10061 · Cited by 80 · see citing works
Competitive quantitative PCR analysis of herpes simplex virus type 1 DNA and latency-associated transcript RNA in latently infected cells of the rat brain
Ramakrishnan, R., Fink, D. J., Jiang, G., et al. (1994) · Journal of Virology · doi:10.1128/jvi.68.3.1864-1873.1994 · Cited by 80 · see citing works
Self-citation
Interaction of Polylysine with the Cellular Receptor for Herpes Simplex Virus Type 1
Langeland, N., Moore, L. J., Holmsen, H., et al. (1988) · Journal of General Virology · doi:10.1099/0022-1317-69-6-1137 · Cited by 79 · see citing works
Enhanced tumor cell killing in the presence of ganciclovir by herpes simplex virus type 1 vector-directed coexpression of human tumor necrosis factor-alpha and herpes simplex virus thymidine kinase.
Moriuchi, S., Oligino, T., Krisky, D. M., et al. (1998) · PubMed · Cited by 78 · see citing works
Activation of herpes simplex virus 1 γ2 genes by viral DNA replication
Mavromara-Nazos, P., & Roizman, B. (1987) · Virology · doi:10.1016/0042-6822(87)90156-5 · Cited by 78 · see citing works
Entry of Mouse Hepatitis Virus into Cells by Endosomal and Nonendosomal Pathways
Nash, T. C., & Buchmeier, M. J. (1997) · Virology · doi:10.1006/viro.1997.8609 · Cited by 78 · see citing works
In vitro Promoter Activity Associated with the Latency-associated Transcript Gene of Herpes Simplex Virus Type 1
Zwaagstra, J. C., Ghiasi, H., Nesburn, A. B., et al. (1989) · Journal of General Virology · doi:10.1099/0022-1317-70-8-2163 · Cited by 75 · see citing works
Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear
Wu, T.-T., Su, Y., Block, T. M., et al. (1996) · Journal of Virology · doi:10.1128/jvi.70.9.5962-5967.1996 · Cited by 73 · see citing works
BAC-VAC, a novel generation of (DNA) vaccines: A bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1
Suter, M., Lew, A. M., Grob, P., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12697 · Cited by 72 · see citing works
Specificity and affinity of binding of herpes simplex virus type 2 glycoprotein B to glycosaminoglycans
Williams, R. K., & Straus, S. E. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1375-1380.1997 · Cited by 72 · see citing works
Bone marrow metastasis in astrocytic gliomata
Hsu, E., Keene, D., Ventureyra, E. C. G., et al. (1998) · Journal of Neuro-Oncology · doi:10.1023/a:1005909127196 · Cited by 70 · see citing works
Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells.
Rubsam, L. Z., Boucher, P. D., Murphy, P. J., et al. (1999) · PubMed · Cited by 70 · see citing works
Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector
Johnson, P. A., Yoshida, K., Gage, F. H., et al. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90072-j · Cited by 70 · see citing works
Latent Herpes Simplex Virus Type 1 DNA Is Not Extensively Methylated in vivo
Dressler, G. R., Rock, D. L., & Fraser, N. (1987) · Journal of General Virology · doi:10.1099/0022-1317-68-6-1761 · Cited by 69 · see citing works
Drug inducible transgene expression in brain using a herpes simplex virus vector
Oligino, T., Poliani, P. L., Wang, Y., et al. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300612 · Cited by 68 · see citing works
Herpes Simplex Virus Type 1 ICP0 Protein Does Not Accumulate in the Nucleus of Primary Neurons in Culture
Chen, X., Li, J., Mata, M. M., Goss, J. R., Wolfe, D. P., Glorioso, J. C., & Fink, D. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.21.10132-10141.2000 · Cited by 67 · see citing works
Self-citation
Herpes Simplex Virus Latency-Associated Transcript Encodes a Protein Which Greatly Enhances Virus Growth, Can Compensate for Deficiencies in Immediate-Early Gene Expression, and Is Likely To Function during Reactivation from Virus Latency
Thomas, S. K., Gough, G., Latchman, D. S., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6618-6625.1999 · Cited by 67 · see citing works
Identification of mar mutations in herpes simplex virus type 1 glycoprotein B which alter antigenic structure and function in virus penetration
Highlander, S. L., Dorney, D. J., Gage, P. J., Holland, T. C., Cai, W., Person, S., Levine, M., & Glorioso, J. C. (1989) · Journal of Virology · doi:10.1128/jvi.63.2.730-738.1989 · Cited by 67 · see citing works
Self-citation
PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant
Ramakrishnan, R., Levine, M., & Fink, D. J. (1994) · Journal of Virology · doi:10.1128/jvi.68.11.7083-7091.1994 · Cited by 65 · see citing works
Self-citation
The role of herpes simplex virus glycoproteins in the virus replication cycle.
Rajčáni, J., & Vojvodová, A. (1998) · PubMed · Cited by 65 · see citing works
A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1
Perng, G., Slanina, S. M., Ghiasi, H., et al. (1996) · Journal of Virology · doi:10.1128/jvi.70.3.2014-2018.1996 · Cited by 64 · see citing works
Gene Therapy Using Hematopoietic Stem Cells: Sisyphus Approaches the Crest
Halene, S., & Kohn, D. B. (2000) · Human Gene Therapy · doi:10.1089/10430340050032366 · Cited by 64 · see citing works
Implications of maturation for viral gene delivery to skeletal muscle
van Deutekom, J. C. T., Floyd, S. S., Booth, D. K., Oligino, T., Krisky, D. M., Marconi, P., Glorioso, J. C., & Huard, J. (1998) · Neuromuscular Disorders · doi:10.1016/s0960-8966(98)00019-4 · Cited by 61 · see citing works
Self-citation
Engineering Herpes Simplex Virus Vectors for CNS Applications
Wolfe, D. P., Goins, W. F., Yamada, M., et al. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7158 · Cited by 61 · see citing works
A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
Perng, G., Slanina, S. M., Yukht, A., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.920-929.1999 · Cited by 58 · see citing works
A cell-free recombination system for site-specific integration of multigenic shuttle plasmids into the herpes simplex virus type 1 genome
Gage, P. J., Sauer, B., Levine, M., et al. (1992) · Journal of Virology · doi:10.1128/jvi.66.9.5509-5515.1992 · Cited by 58 · see citing works
High efficiency gene transfer to the central nervous system of rodents and primates using herpes virus vectors lacking functional ICP27 and ICP34.5
Mk, H., Kershaw, T. R., Gibb, B. J. M., et al. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300700 · Cited by 58 · see citing works
Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model
Gómez-Navarro, J., Contreras, J. L., Arafat, W. O., Jiang, X. L., Krisky, D. M., Oligino, T., Marconi, P., Hubbard, B., Glorioso, J. C., Curiel, D. T., et al. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301054 · Cited by 58 · see citing works
Self-citation
Pharmacological modulation of the bystander effect in the herpes simplex virus thymidine kinase/ganciclovir gene therapy system
Robe, P. A. J. T., Princen, F., Martin, D., et al. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00315-4 · Cited by 57 · see citing works
LacZ Gene Transfer to Skeletal Muscle Using a Replication-Defective Herpes Simplex Virus Type 1 Mutant Vector
Huard, J., Akkaraju, G. R., Watkins, S. C., et al. (1997) · Human Gene Therapy · doi:10.1089/hum.1997.8.4-439 · Cited by 57 · see citing works
Alterations in Glycoprotein gB Specified by Mutants and Their Partial Revertants in Herpes Simplex Virus Type 1 and Relationship to Other Mutant Phenotypes
Haffey, M. L., & Spear, P. G. (1980) · Journal of Virology · doi:10.1128/jvi.35.1.114-128.1980 · Cited by 56 · see citing works
Localization of the gD-Binding Region of the Human Herpes Simplex Virus Receptor, HveA
Whitbeck, J. C., Connolly, S. A., Willis, S. H., et al. (2001) · Journal of Virology · doi:10.1128/jvi.75.1.171-180.2001 · Cited by 56 · see citing works
The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency
Lokensgard, J. R., Berthommé, H., & Feldman, L. T. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6714-6719.1997 · Cited by 55 · see citing works
Pseudotyping of Glycoprotein D-Deficient Herpes Simplex Virus Type 1 with Vesicular Stomatitis Virus Glycoprotein G Enables Mutant Virus Attachment and Entry
Anderson, D. B., Laquerre, S. G., Goins, W. F., Cohen, J. B., & Glorioso, J. C. (2000) · Journal of Virology · doi:10.1128/jvi.74.5.2481-2487.2000 · Cited by 54 · see citing works
Self-citation
Herpes simplex virus type 1 vector mediated gene transfer to muscle.
Huard, J., Goins, W. F., & Glorioso, J. C. (1995) · PubMed · Cited by 54 · see citing works
Self-citation
Tumor necrosis factor as an antineoplastic agent: pitfalls and promises
Mueller, H. (1998) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050255 · Cited by 53 · see citing works
Analysis of the 2-kilobase latency-associated transcript expressed in PC12 cells productively infected with herpes simplex virus type 1: evidence for a stable, nonlinear structure
Rødahl, E., & Haarr, L. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1703-1707.1997 · Cited by 53 · see citing works
Selection of a nonconsensus branch point is influenced by an RNA stem-loop structure and is important to confer stability to the herpes simplex virus 2-kilobase latency-associated transcript
Krummenacher, C., Zabolotny, J. M., & Fraser, N. (1997) · Journal of Virology · doi:10.1128/jvi.71.8.5849-5860.1997 · Cited by 52 · see citing works
Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression
Marshall, K. R., Lachmann, R., Efstathiou, S., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.2.956-964.2000 · Cited by 52 · see citing works
Immunohistochemical localization of delta- and mu-opioid receptors in primate spinal cord
Honda, C. N., & Arvidsson, U. (1995) · Neuroreport · doi:10.1097/00001756-199505090-00019 · Cited by 51 · see citing works

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Lee, C. S., Bishop, E. S., Zhang, R., Yu, X., Farina, E. M., Yan, S., Zhao, C., Zeng, Z., Shu, Y., Wu, X., et al. (2017) · Genes & Diseases · doi:10.1016/j.gendis.2017.04.001 · Cited by 691 · see citing works
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Ghosh, S., Brown, A. M., Jenkins, C., & Campbell, K. (2020) · Applied Biosafety · doi:10.1177/1535676019899502 · Cited by 218 · see citing works
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Authors: Burton, E. A., Fink, D. J., & Glorioso, J. C.
Affiliations: University of Oxford (GB)
University of Pittsburgh (US)
ORCID: Burton, Edward A.
Fink, David J.
Glorioso, Joseph C.
Venue: DNA and Cell Biology
Publisher: SAGE Publications
Published: 2002-12
Volume: 21
Issue: 12
Pages: 915-936
ISSN: 1044-5498 (ISSN-L)
1557-7430
DOI: 10.1089/104454902762053864
OpenAlex: W2173140585
Cited by: 92
References: 245
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 6 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 2 · 2012: 1
FWCI: 1.01
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: DNA and Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: herpes simplex virus vectors, gene delivery, replication-defective vectors, immediate early genes, latent infection, sensory neurons, viral tropism, neurological disease models, glioma, peripheral neuropathy, chronic pain, neurodegeneration, viral vectors
MeSH terms: Animals, Defective Viruses, Genetic Vectors, Glioma, Herpes Simplex, Humans, Nervous System, Virus Replication, Genetic Therapy, Gene Expression Regulation, Viral, Drug Delivery Systems, Central Nervous System Neoplasms, Gene Transfer Techniques, Simplexvirus, Transgenes

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Gene Delivery Using Herpes Simplex Virus Vectors

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