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Cited by 347Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Epidemiology and prevention of clinical and subclinical hypothyroidism.

Vanderpump, Mark P. J., Tunbridge, W. Michael G.·2002·Thyroid
DOI 10.1089/105072502761016458
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Abstract

Iodine deficiency is the most common cause of hypothyroidism worldwide. In persons living in iodine-replete areas, causes are congenital, spontaneous because of chronic autoimmune disease (atrophic autoimmune thyroiditis or goitrous autoimmune thyroiditis [Hashimoto's thyroiditis]), or iatrogenic because of goitrogens, drugs, or destructive treatment for thyrotoxicosis. Screening for congenital hypothyroidism exists and its use prevents mental retardation. The prevalence of spontaneous hypothyroidism is between 1% and 2% and is more common in older women and 10 times more common in women than in men. A significant proportion of subjects have asymptomatic chronic autoimmune thyroiditis and 8% of women (10% of women over 55 years of age) and 3% of men have subclinical hypothyroidism. Approximately one third of patients with newly diagnosed overt hypothyroidism have received destructive therapy for hyperthyroidism and indefinite surveillance is required. There is not much that can be done to prevent the occurrence of spontaneous autoimmune hypothyroidism, but if identified early, something can be done to prevent progression to overt disease. Controversy exists as to whether healthy adults would benefit from screening for autoimmune thyroid disease because a significant proportion of subjects tested will have evidence of mild thyroid failure. Case finding in women at menopause or visiting a primary care physician with nonspecific symptoms appears justified.

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Crossref · 10.1089/105072502761016458

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75 of 75 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 12

  1. Bastenie PA, 1982, Acta Cardiol, 7, 365
  2. 10.1210/jc.86.10.4860 · DOI
  3. Perk M, 1997, Can J Cardiol, 13, 273
  4. Vanderpump MPJ, 1996, Thyroid, 6, 155
  5. 10.1210/jc.86.8.3611 · DOI
  6. Kendall-Taylor P, 1984, BMJ, 28, 9361
  7. Tamai H, 1989, Metabolism, 69, 49
  8. Littley MD, 1991, Q J Med, 78, 265
  9. Parle JV, 1993, Br J Gen Pract, 43, 107
  10. 10.1210/jc.84.6.1813 · DOI
  11. Pueschel SM, 1985, Am J Dis Child, 139, 636
  12. Hardisty CA, 1990, J R Coll Phys Lond, 24, 36

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Metadata

Authors
Vanderpump, M. P. J., & Tunbridge, W. M. G.
Affiliations
  • The Royal Free Hospital (GB)
  • John Radcliffe Hospital (GB)
Venue
Thyroid
Publisher
SAGE Publications
Published
2002-10
Volume
12
Issue
10
Pages
839-847
ISSN
  • 1050-7256 (ISSN-L)
  • 1557-9077
DOI
10.1089/105072502761016458
OpenAlex
W2130124581
Cited by
347
References
74
Citations by year
2026: 4 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 15 · 2021: 17 · 2020: 16 · 2019: 30 · 2018: 27 · 2017: 12 · 2016: 10 · 2015: 19 · 2014: 19 · 2013: 24 · 2012: 15
FWCI
3.76
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Thyroid (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
hypothyroidism, subclinical hypothyroidism, iodine deficiency, autoimmune thyroiditis, Hashimoto's thyroiditis, congenital hypothyroidism screening, prevalence, sex differences, menopause, prevention
MeSH terms
Humans, Hypothyroidism, Mass Screening, Severity of Illness Index, Prevalence

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